GlpBio

Hedgehog

Hh (Hedgehog) signalling is a evolutionarily conserved pathway that is critical for embryonic development, tissue and organ morphogenesis. Mammalian Hh protein ligands include Sonic Hh, Desert Hh and Indian Hh. Dysfunctions of Hh singalling lead to developmental abnormalities and cancer.

Hedgehog 相关产品(43)

  • GC10359 structure
    GC10359GANT61
    CAS: 500579-04-4
    纯度: >99.50% / >98.00%

    GANT61 能够有效阻断 GLI1 和 GLI2 诱导的转录，IC50 为 5 μM。

  • GC10493 structure
    GC10493GDC-0449 (Vismodegib)
    CAS: 879085-55-9
    纯度: >98.00%

    GDC-0449 (Vismodegib)是一种具有口服活性和高效选择性的Smoothened（SMO）受体抑制剂，可抑制Hedgehog信号通路，IC 50 值为3.0nM。同时，也可抑制P-gp和ABCG2的活性，IC 50 值分别为3.0μM和1.4μM。

  • GC11045 structure
    GC11045HPI 1
    CAS: 599150-20-6
    纯度: >94.00%

    A Hedgehog pathway inhibitor

  • GC11111 structure
    GC11111Jervine
    CAS: 469-59-0
    纯度: >99.00%

    An inhibitor of the hedgehog signaling pathway

  • GC11193 structure
    GC11193SANT-2
    CAS: 329196-48-7
    纯度: >98.00%

    A Smoothened receptor antagonist

  • GC11476 structure
    GC11476Ciliobrevin A
    CAS: 302803-72-1
    纯度: >99.50%

    A hedgehog pathway inhibitor

  • GC12429 structure
    GC12429AY 9944 dihydrochloride
    CAS: 366-93-8
    纯度: >99.50% / >98.00%

    A cholesterol synthesis inhibitor

  • GC13280 structure
    GC13280PF-5274857
    CAS: 1373615-35-0
    纯度: >98.00%

    PF-5274857 是一种有效的、选择性的、具有口服活性的脑渗透性 Smo 拮抗剂，IC50 为 5.8 nM，Ki 为 4.6 nM。 PF-5274857 具有研究肿瘤类型的潜力，包括由激活的 Hh 通路驱动的脑肿瘤和脑转移。

  • GC13441 structure
    GC13441Cyclopamine
    CAS: 4449-51-8
    纯度: >99.50%

    Cyclopamine是一种天然存在的Hedgehog (Hh)特异性小分子信号甾体生物碱抑制剂，对肿瘤生长具有深远的抑制作用，在人乳腺癌细胞中具有显著的抗侵袭、抗增殖和抗雌激素活性。

  • GC14715 structure
    GC14715AZ 12080282 dihydrochloride
    纯度: >98.00%

    刺猬抑制剂

  • GC15064 structure
    GC15064Purmorphamine
    CAS: 483367-10-8
    纯度: >99.50% / >98.00%

    Purmorphamine是第一个针对Smoothened蛋白开发的小分子激动剂, 能够直接结合并激活Smo,阻断BODIPY-cyclopamine与Smo结合。

  • GC15256 structure
    GC15256JK 184
    CAS: 315703-52-7
    纯度: >99.50%

    An inhibitor of downstream hedgehog signaling

  • GC15683 structure
    GC15683LY2940680
    CAS: 1258861-20-9
    纯度: >99.50%

    A Smo antagonist

  • GC15889 structure
    GC15889SANT-1
    CAS: 304909-07-7
    纯度: >99.50%

    An antagonist of Smoothened

  • GC16789 structure
    GC16789GANT 58
    CAS: 64048-12-0
    纯度: >99.50%

    An inhibitor of Gli transcription

  • GC17153 structure
    GC17153CHIR-99021 (CT99021) HCl
    CAS: 1797989-42-4
    纯度: >99.50%

    A selective GSK3 inhibitor

  • GC11217 structure
    GC11217CUR 61414
    CAS: 334998-36-6
    纯度: >99.00%

    A potent inhibitor of hedgehog-induced activity

  • GC12068 structure
    GC12068SAG
    CAS: 912545-86-9
    纯度: >99.50%

    SAG(Smoothened Agonist)是一种有效的Smo受体激动剂。

  • GC13630 structure
    GC13630MK-4101
    CAS: 935273-79-3
    纯度: >98.00%

    A Smoothened receptor antagonist

  • GC15284 structure
    GC15284U 18666A
    CAS: 3039-71-2
    纯度: >95.00% / >98.00%

    U18666A是一种具有细胞渗透性和两亲性的小分子，可以抑制3β羟基甾醇-Δ（24）还原酶 （DHCR24）活性, 从而阻止胆固醇从晚期核内体和溶酶体外流[2]。

  • GC15422 structure
    GC1542220(S)-Hydroxycholesterol
    CAS: 516-72-3
    纯度: >98.00%

    An allosteric Smo agonist

  • GC17713 structure
    GC17713Oxy-16
    CAS: 596-94-1

    A synthetic oxysterol

  • GC18475 structure
    GC18475Robotnikinin
    CAS: 1132653-79-2

    A direct inhibitor of sonic hedgehog

  • GC37573 structure
    GC37573RU-SKI 43
    CAS: 1043797-53-0

    An inhibitor of hedgehog acyltransferase