Lipoxygenase
Lipoxygenase(脂氧合酶)
Lipoxygenases (LOXs) are dioxygenases that catalyze the formation of corresponding hydroperoxides from polyunsaturated fatty acids such as linoleic acid and arachidonic acid. Thre are six LOX isoforms have been found in the humans and mice. 5-Lipoxygenase (5-LOX) is a distinct isoform playing an important role in asthma and inflammation. 5-LOX causes the constriction of bronchioles in response to cysteinyl leukotrienes such as LTC4, thus leading to asthma. 5-LOX also induces neutrophilic inflammation by its recruitment in response to LTB4. 12-Lipoxygenase (12-LOX) is an isoform expressed in epithelial cells and myeloid cells including platelets. 12-LOX can be found in the epithelial cells of the skin. 12-LOX is a potential target for novel anti-platelet therapeutics.15-Lipoxygenase (15-LOX) is expressed in epithelial cells and leukocytes, has different substrate specificity in the humans and mice.15-LOX-1 is a target of nonsteroidal anti-inflammatory drug-induced apoptosis in colorectal cancer cells.
Lipoxygenase 相关产品(254)
- GC467327(S),17(S)-dihydroxy-8(E),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic AcidCAS: 887752-13-8纯度: >98.00%
A metabolite of DPA with anti-inflammatory properties
- GC46798Adapalene-d3CAS: 1276433-89-6纯度: >99.00%
An internal standard for the quantification of adapalene
- GC47323Etofenamate-d4CAS: 1329837-73-1纯度: >99.00%
An internal standard for the quantification of etofenamate
- GC47558Leukotriene C4-d5 methyl esterCAS: 73958-10-8纯度: >99.00%
A neuropeptide with diverse biological activities
- GC47575Loratadine-d5CAS: 1020719-57-6纯度: >99.00%
An internal standard for the quantification of loratadine
- GC47701Montelukast-d6 (sodium salt)CAS: 2673270-26-1纯度: >99.00%
A neuropeptide with diverse biological activities
- GC47716Myxochelin ACAS: 120243-02-9纯度: >98.00%
A microbial metabolite with diverse biological activities
- GC48041Resolvin D1-d5CAS: 1881277-32-2纯度: >99.00%
An internal standard for the quantification of RvD1
- GC48042Resolvin D2-d5CAS: 1881277-33-3纯度: >95.00%
An internal standard for the quantification of RvD2
- GC48267Zileuton-d4CAS: 1189878-76-9纯度: >99.00%
An internal standard for the quantification of zileuton
- GC48659UmbellipreninCAS: 532-16-1; 23838-17-7纯度: >98.00%
A prenylated coumarin with diverse biological activities
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC46679 | 5(S)-HETE-d8 | 330796-62-8 | >99.00% | |
An internal standard for the quantification of 5-HETE | ||||
| GC46732 | 7(S),17(S)-dihydroxy-8(E),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic Acid | 887752-13-8 | >98.00% | |
A metabolite of DPA with anti-inflammatory properties | ||||
| GC46753 | 9(S),12(S),13(S)-TriHOME | 97134-11-7 | >98.00% | |
An oxylipin | ||||
| GC46755 | 9(S)-HODE-13C18 | - | >98.00% | |
A neuropeptide with diverse biological activities | ||||
| GC46798 | Adapalene-d3 | 1276433-89-6 | >99.00% | |
An internal standard for the quantification of adapalene | ||||
| GC47312 | Etherolenic Acid | 2247927-22-4 | >95.00% | |
A divinyl ether oxylipin | ||||
| GC47323 | Etofenamate-d4 | 1329837-73-1 | >99.00% | |
An internal standard for the quantification of etofenamate | ||||
| GC47555 | Leukotriene A4-d5 methyl ester | - | >99.00% | |
A neuropeptide with diverse biological activities | ||||
| GC47558 | Leukotriene C4-d5 methyl ester | 73958-10-8 | >99.00% | |
A neuropeptide with diverse biological activities | ||||
| GC47570 | Lipoxygenin | 2247911-68-6 | >98.00% | |
An inhibitor of 5-LO | ||||
| GC47574 | Loratadine-d4 | 2748435-73-4 | >99.00% | |
A neuropeptide with diverse biological activities | ||||
| GC47575 | Loratadine-d5 | 1020719-57-6 | >99.00% | |
An internal standard for the quantification of loratadine | ||||
| GC47598 | Maresin 1-d5 | 1268720-28-0 | >99.00% | |
A neuropeptide with diverse biological activities | ||||
| GC47599 | Maresin 2-d5 | 1639809-46-3 | >99.00% | |
A neuropeptide with diverse biological activities | ||||
| GC47701 | Montelukast-d6 (sodium salt) | 2673270-26-1 | >99.00% | |
A neuropeptide with diverse biological activities | ||||
| GC47716 | Myxochelin A | 120243-02-9 | >98.00% | |
A microbial metabolite with diverse biological activities | ||||
| GC48035 | RCTR1 | 2095607-49-9 | >98.00% | |
A specialized pro-resolving mediator | ||||
| GC48041 | Resolvin D1-d5 | 1881277-32-2 | >99.00% | |
An internal standard for the quantification of RvD1 | ||||
| GC48042 | Resolvin D2-d5 | 1881277-33-3 | >95.00% | |
An internal standard for the quantification of RvD2 | ||||
| GC48043 | Resolvin D3-d5 | 916888-47-6 | >99.00% | |
A neuropeptide with diverse biological activities | ||||
| GC48044 | Resolvin E1-d4 | - | >99.00% | |
A neuropeptide with diverse biological activities | ||||
| GC48045 | Resolvin E4 | 1781227-87-9 | >95.00% | |
A specialized pro-resolving mediator | ||||
| GC48267 | Zileuton-d4 | 1189878-76-9 | >99.00% | |
An internal standard for the quantification of zileuton | ||||
| GC48659 | Umbelliprenin | 532-16-1; 23838-17-7 | >98.00% | |
A prenylated coumarin with diverse biological activities | ||||