Resolvin E1-d4 (RvE1-d4) is intended for use as an internal standard for the quantification of RvE1 by GC- or LC-MS. RvE1 is a trihydroxy eicosapentaenoic acid metabolite that has been identified in mouse inflammatory exudates and in human plasma when subjects are treated with both aspirin and supplemental EPA.1,2,3 RvE1 promotes inflammatory resolution in numerous disease models, including experimental colitis, asthma, atherosclerosis, type 2 diabetes, and HSV-1-induced stromal keratitis.4,5,6,7,8,9,10
1.Serhan, C.N., Clish, C.B., Brannon, J., et al.Novel functional sets of lipid-derived mediators with antiinflammatory actions generated from omega-3 fatty acids via cyclooxygenase 2-nonsteroidal antiinflammatory drugs and transcellular processingJournal of Experimental Medicine192(8)1197-1204(2000) 2.Serhan, C.N., Hong, S., Gronert, K., et al.Resolvins: A family of bioactive products of ω-3 fatty acid transformation circuits by aspirin treatment that counter proinflammation signalsJ. Exp. Med.196(8)1025-1037(2002) 3.Arita, M., Bianchini, F., Aliberti, J., et al.Sterochemical assignment, antiinflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1Journal of Experimental Medicine201(5)713-722(2005) 4.Arita, M., Yoshida, M., Hong, S., et al.Resolvin E1, an endogenous lipid mediator derived from omega-3 eicosapentaenoic acid, protects against 2,4,6-trinitrobenzene sulfonic acid-induced colitisProceedings of the National Academy of Sciences of the United States of America102(21)7671-7676(2005) 5.Aoki, H., Hisada, T., Ishizuka, T., et al.Resolvin E1 dampens airway inflammation and hyperresponsiveness in a murine model of asthmaBiochemical and Biophysical Research Communications367509-515(2008) 6.Haworth, O., Cernadas, M., and Levy, B.D.NK cells are effectors for resolvin E1 in the timely resolution of allergic airway inflammationJournal of Immunology186(11)6129-6135(2011) 7.Campbell, E.K., MacManus, C.F., Kominsky, D.J., et al.Resolvin E1-induced intestinal alkaline phosphatase promotes resolution of inflammation through LPS detoxificationProceedings of the National Academy of Sciences of the United States of America107(32)14298-14303(2010) 8.Hasturk, H., Abdallah, R., Kantarck, A., et al.Resolvin E1 (RvE1) attenuates atherosclerotic plaque formation in diet and inflammation-induced atherogenesisArteriosclerosis, Thrombosis, and Vascular Biology35(5)1123-1133(2015) 9.Herrera, N.S., Hasturk, H., Kantarck, A., et al.Impact of resolvin E1 on murine neutrophil phagocytosis in type 2 diabetesInfection and Immunity83(2)792-801(2015) 10.Rajasagi, N.K., Reddy, P.B.J., Suryawanshi, A., et al.Controlling herpes simplex virus-induced ocular inflammatory lesions with the lipid-derived mediator resolvin E1J. Immunol.186(3)1735-1746(2011)