Lipoxygenase
Lipoxygenase(脂氧合酶)
Lipoxygenases (LOXs) are dioxygenases that catalyze the formation of corresponding hydroperoxides from polyunsaturated fatty acids such as linoleic acid and arachidonic acid. Thre are six LOX isoforms have been found in the humans and mice. 5-Lipoxygenase (5-LOX) is a distinct isoform playing an important role in asthma and inflammation. 5-LOX causes the constriction of bronchioles in response to cysteinyl leukotrienes such as LTC4, thus leading to asthma. 5-LOX also induces neutrophilic inflammation by its recruitment in response to LTB4. 12-Lipoxygenase (12-LOX) is an isoform expressed in epithelial cells and myeloid cells including platelets. 12-LOX can be found in the epithelial cells of the skin. 12-LOX is a potential target for novel anti-platelet therapeutics.15-Lipoxygenase (15-LOX) is expressed in epithelial cells and leukocytes, has different substrate specificity in the humans and mice.15-LOX-1 is a target of nonsteroidal anti-inflammatory drug-induced apoptosis in colorectal cancer cells.
Lipoxygenase 相关产品(254)
- GC48738(±)12-HETE-d8CAS: 2525175-25-9纯度: >99.00%
An internal standard for the quantification of 12-HETE
- GC48739(±)15-HETE-d8CAS: 2525175-31-7纯度: >99.00%
An internal standard for the quantification of 15-HETE
- GC48850Carbazomycin CCAS: 108073-62-7纯度: >95.00%
A bacterial metabolite with diverse biological activities
- GC48893Carbazomycin BCAS: 75139-38-7纯度: >95.00%
A bacterial metabolite with diverse biological activities
- GC49590Docosahexaenoic Acid 1,2,3,4-13C纯度: >95.00%
An internal standard for the quantification of DHA
- GC497301-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE-d11纯度: >99.00%
An internal standard for the quantification of 1-stearoyl-2-15(S)-HETE- sn -glycero-3-PE
- GC4989415(S)-HETE-d8 ethyl ester纯度: >99.00%
An internal standard for the quantification of 15(S)-HETE ethyl ester
- GC524135-Aminosalicylic Acid-d7纯度: >99.00%
An internal standard for the quantification of 5-aminosalicylic acid
- GC62040Cinnamyl-3,4-dihydroxy-α-cyanocinnamateCAS: 132465-11-3纯度: >99.50%
Cinnamyl-3,4-dihydroxy-α-cyanocinnamate (CDC) 是一种有效的 12/15 脂氧合酶 (12/15-LO) 抑制剂。Cinnamyl-3,4-dihydroxy-α-cyanocinnamate 可用于研究1型糖尿病。
- GC640783-O-Acetyl-11-hydroxy-beta-boswellic acidCAS: 146019-25-2纯度: >98.00%
3-O-Acetyl-11-hydroxy-beta-boswellic acid 是一种5-脂氧合酶 (5-LO) 抑制剂。
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC48738 | (±)12-HETE-d8 | 2525175-25-9 | >99.00% | |
An internal standard for the quantification of 12-HETE | ||||
| GC48739 | (±)15-HETE-d8 | 2525175-31-7 | >99.00% | |
An internal standard for the quantification of 15-HETE | ||||
| GC48850 | Carbazomycin C | 108073-62-7 | >95.00% | |
A bacterial metabolite with diverse biological activities | ||||
| GC48893 | Carbazomycin B | 75139-38-7 | >95.00% | |
A bacterial metabolite with diverse biological activities | ||||
| GC48972 | Resolvin E2 | 865532-70-3 | >95.00% | |
A specialized pro-resolving mediator | ||||
| GC48993 | Protectin D1-d5 | - | >99.00% | |
An internal standard for the quantification of protectin D1 | ||||
| GC49098 | Olsalazine-13C6 | - | >98.00% | |
An internal standard for the quantification of olsalazine | ||||
| GC49356 | 17(S)-HDoTE | 105835-39-0 | >98.00% | |
A metabolite of adrenic acid | ||||
| GC49364 | 3-Hydroxycoumarin | 939-19-5 | >97.00% | |
A coumarin with diverse biological activities | ||||
| GC49386 | Tepoxalin | 103475-41-8 | >98.00% | |
A dual inhibitor of COX and 5-LO | ||||
| GC49590 | Docosahexaenoic Acid 1,2,3,4-13C | - | >95.00% | |
An internal standard for the quantification of DHA | ||||
| GC49597 | Leukotriene B4-d5 | - | >99.00% | |
An internal standard for the quantification of LTB 4 | ||||
| GC49696 | FPL 55712 (sodium salt) | 40786-08-1 | >98.00% | |
A leukotriene receptor antagonist | ||||
| GC49730 | 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE-d11 | - | >99.00% | |
An internal standard for the quantification of 1-stearoyl-2-15(S)-HETE- sn -glycero-3-PE | ||||
| GC49758 | CAY10788 | 119515-00-3 | >95.00% | |
A CysLT 1 receptor antagonist | ||||
| GC49778 | Etheroleic Acid | 169217-38-3 | >98.00% | |
A divinyl ether oxylipin | ||||
| GC49849 | 3-Aminosalicylic Acid | 570-23-0 | >98.00% | |
A salicylic acid derivative | ||||
| GC49894 | 15(S)-HETE-d8 ethyl ester | - | >99.00% | |
An internal standard for the quantification of 15(S)-HETE ethyl ester | ||||
| GC52105 | Montelukast | 158966-92-8 | >99.00% | |
A CysLT 1 receptor antagonist | ||||
| GC52413 | 5-Aminosalicylic Acid-d7 | - | >99.00% | |
An internal standard for the quantification of 5-aminosalicylic acid | ||||
| GC61180 | Phenidone | 92-43-3 | >98.00% | |
Phenidone (1-phenyl-3-pyrazolidinone), a dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LOX), is an organic compound that is primarily used as a photographic developer. | ||||
| GC62040 | Cinnamyl-3,4-dihydroxy-α-cyanocinnamate | 132465-11-3 | >99.50% | |
Cinnamyl-3,4-dihydroxy-α-cyanocinnamate (CDC) 是一种有效的 12/15 脂氧合酶 (12/15-LO) 抑制剂。Cinnamyl-3,4-dihydroxy-α-cyanocinnamate 可用于研究1型糖尿病。 | ||||
| GC64078 | 3-O-Acetyl-11-hydroxy-beta-boswellic acid | 146019-25-2 | >98.00% | |
3-O-Acetyl-11-hydroxy-beta-boswellic acid 是一种5-脂氧合酶 (5-LO) 抑制剂。 | ||||
| GC64621 | 4-Nitrocatechol | 3316-09-4 | - | |
4-Nitrocatechol 是一种有效的脂氧合酶 (lipoxygenase) 抑制剂。 | ||||