Resolvin D3-d5 by GC- or LC-MS. RVD3 is a DHA-derived product first identified in mouse inflammatory exudates.1 It reduces neutrophil infiltration in vivo in both mouse peritonitis and dermal inflammation. In addition to suppressing leukocyte migration, RVD3 enhances macrophage phagocytosis and efferocytosis.2 Unlike other resolvins, RVD3 appears late in resolution in mouse peritonitis.2,3
1.Serhan, C.N., Hong, S., Gronert, K., et al.Resolvins: A family of bioactive products of ω-3 fatty acid transformation circuits by aspirin treatment that counter proinflammation signalsJ. Exp. Med.196(8)1025-1037(2002) 2.Dalli, J., Winkler, J.W., Colas, R.A., et al.Resolvin D3 and aspirin-triggered resolvin D3 are potent immunoresolventsChem. Biol.20(2)188-201(2015) 3.Serhan, C.N.Novel pro-resolving lipid mediators in inflammation are leads for resolution physiologyNature510(7503)92-101(2014)