Resolvin D2-d5

Resolvin D2-d5 (RvD2-d₅) is intended for use as an internal standard for the quantification of resolvin D2 by GC- or LC-MS. Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA).¹ In addition to being anti-inflammatory, resolvins promote the resolution of the inflammatory response back to a non-inflamed state.² Resolvin D2 is produced physiologically from the sequential oxygenation of DHA by 15- and 5-lipoxygenase and functions to dampen excessive neutrophil trafficking to sites of inflammation.³ It reduces zymosan-stimulated PMN infiltration by 70% at doses as low as 10 pg per mouse and significantly reduces PAF-stimulated leukocyte adherence and emigration at 1 nM.³ Also, by stimulating nitric oxide production, resolvin D2 dose dependently decreases leukocyte-endothelial interactions. In a murine model of sepsis, resolvin D2 reduces leukocyte and PMN infiltration, decreases production of pro-inflammatory cytokines, and promotes phagocyte-mediated bacterial clearance.³

1.Hong, S., Gronert, K., Devchand, P.R., et al.Novel docosatrienes and 17S-resolvins generated from docosahexaenoic acid in murine brain, human blood, and glial cells. Autacoids in anti-inflammationJ. Biol. Chem.278(17)14677-14687(2003) 2.Ariel, A., and Serhan, C.N.Resolvins and protectins in the termination program of acute inflammationTRENDS in Immunology28(4)176-183(2007) 3.Spite, M., Norling, L.V., Summers, L., et al.Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsisNature461(7268)1287-1291(2009)