Endogenous Metabolite
Endogenous Metabolite(内源性代谢物)
Metabolite results when a drug is metabolized into a modified form which continues to produce effects. A metabolome in a given body fluid is influenced by endogenous factors such as age, sex, body composition and genetics as well as underlying pathologies.The levels of the enormous array of unique small-molecule metabolites are usually kept tightly regulated by the activity of a very large array of enzymes and transporters responsible for the production, transformation, degradation, and compartmentalization of these small molecules.The levels of the endogenous small molecules present in the brain are normally tightly regulated.
Endogenous Metabolite 相关产品(1712)
- GC17591D-erythro-Sphingosine (synthetic)CAS: 123-78-4纯度: >98.00%
D-erythro-sphingosine (Erythrosphingosine) 是一种非常有效的 p32 激酶激活剂，EC50 值为 8μM。
- GC17823L-Cysteinesulfinic acidCAS: 1115-65-7纯度: >98.00%
L-半胱氨酸亚磺酸是几种大鼠代谢型谷氨酸受体 (mGluR) 的有效激动剂，对 mGluR1、mGluR5、mGluR2、mGluR4、mGluR6 和 mGluR8 的 pEC50 分别为 3.92、4.6、3.9、2.7、4.0 和 3.94 .
- GC17978Vitamin D2 (Ergocalciferol)CAS: 50-14-6纯度: >98.00%
A vitamin produced in fungi and invertebrates
- GC18002Vitamin B12CAS: 68-19-9纯度: >99.50% / >98.00%
Vitamin B12是一种含钴的水溶性维生素，作为甲硫氨酸合酶和L-甲基丙二酰辅酶A变位酶的辅助因子。
- GC18105EnterostatinCAS: 117830-79-2纯度: >99.50% / >98.00%
A pentapeptide involved in the regulation of food intake
- GC18147Tretinoin (Aberela)CAS: 302-79-4纯度: >99.50% / >98.00%
Tretinoin (Aberela) 是一种维生素 A 衍生的非肽类亲脂性小分子，可作为核 RA 受体 (RAR) 的配体，将其从转录抑制因子转化为激活因子 .在培养的人系膜细胞中，维甲酸 (Aberela) 以剂量和时间依赖性方式增加还原型谷胱甘肽含量和过氧化氢酶活性，从而阻止 H2O2 的细胞毒性。
- GC18232Prostaglandin D2CAS: 41598-07-6纯度: >98.00% / >99.00%
A major prostaglandin produced by mast cells
- GC183899-cis RetinalCAS: 514-85-2纯度: >98.00% / >95.00%
9-cis Retinal是一种天然视黄醇，由顺式视黄醇脱氢酶（cRDH）氧化9-cis Retinol生成，能够结合视黄醇结合蛋白（CRBP）。
- GC18567β-hydroxy Pyruvic AcidCAS: 1113-60-6纯度: >98.00%
A metabolite in the process of photorespiration
- GC18583D-α-Hydroxyglutaric AcidCAS: 13095-47-1纯度: >98.00%
D-α-Hydroxyglutaric Acid是α-酮戊二酸（α-KG）的弱竞争性拮抗剂（K i = 10.87mM）。
- GC186283-Methylcrotonyl GlycineCAS: 33008-07-0纯度: >99.00%
A metabolite with diverse biological activities
- GC18663Leukotriene C4CAS: 72025-60-6纯度: >97.00% / >95.00%
The parent cysteinyl leukotriene produced by LTC 4 synthase catalyzed conjugation of glutathione to LTA 4
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC17591 | D-erythro-Sphingosine (synthetic) | 123-78-4 | >98.00% | |
D-erythro-sphingosine (Erythrosphingosine) 是一种非常有效的 p32 激酶激活剂，EC50 值为 8μM。 | ||||
| GC17777 | Palmitoylethanolamide | 544-31-0 | >98.00% | |
An endogenous cannabinoid | ||||
| GC17814 | L-Sorbose | 87-79-6 | >95.00% | |
A monosaccharide | ||||
| GC17823 | L-Cysteinesulfinic acid | 1115-65-7 | >98.00% | |
L-半胱氨酸亚磺酸是几种大鼠代谢型谷氨酸受体 (mGluR) 的有效激动剂，对 mGluR1、mGluR5、mGluR2、mGluR4、mGluR6 和 mGluR8 的 pEC50 分别为 3.92、4.6、3.9、2.7、4.0 和 3.94 . | ||||
| GC17829 | 1-Hexadecanol | 36653-82-4 | - | |
鲸蜡醇（1-Hexadecanol）是一种合成的固体脂肪醇和非离子表面活性剂，是一种亲脂性底物，鲸蜡醇在药物制剂中用作乳化剂。 | ||||
| GC17902 | Inosine | 58-63-9 | >99.00% / >98.00% | |
A purine nucleoside | ||||
| GC17978 | Vitamin D2 (Ergocalciferol) | 50-14-6 | >98.00% | |
A vitamin produced in fungi and invertebrates | ||||
| GC17985 | Chenodeoxycholic Acid | 474-25-9 | >98.00% | |
A primary bile acid | ||||
| GC18002 | Vitamin B12 | 68-19-9 | >99.50% / >98.00% | |
Vitamin B12是一种含钴的水溶性维生素，作为甲硫氨酸合酶和L-甲基丙二酰辅酶A变位酶的辅助因子。 | ||||
| GC18075 | Erythritol | 149-32-6 | - | |
赤藓糖醇是一种糖醇，天然存在于各种食物中（例如。 | ||||
| GC18105 | Enterostatin | 117830-79-2 | >99.50% / >98.00% | |
A pentapeptide involved in the regulation of food intake | ||||
| GC18147 | Tretinoin (Aberela) | 302-79-4 | >99.50% / >98.00% | |
Tretinoin (Aberela) 是一种维生素 A 衍生的非肽类亲脂性小分子，可作为核 RA 受体 (RAR) 的配体，将其从转录抑制因子转化为激活因子 .在培养的人系膜细胞中，维甲酸 (Aberela) 以剂量和时间依赖性方式增加还原型谷胱甘肽含量和过氧化氢酶活性，从而阻止 H2O2 的细胞毒性。 | ||||
| GC18224 | Cholesterol α-Linolenate | 2545-22-4 | >98.00% | |
A cholesterol ester | ||||
| GC18232 | Prostaglandin D2 | 41598-07-6 | >98.00% / >99.00% | |
A major prostaglandin produced by mast cells | ||||
| GC18289 | Lathosterol | 80-99-9 | >95.00% | |
An intermediate in the biosynthesis of cholesterol | ||||
| GC18389 | 9-cis Retinal | 514-85-2 | >98.00% / >95.00% | |
9-cis Retinal是一种天然视黄醇，由顺式视黄醇脱氢酶（cRDH）氧化9-cis Retinol生成，能够结合视黄醇结合蛋白（CRBP）。 | ||||
| GC18398 | Sitostanol | 83-45-4 | >99.00% / >98.00% | |
Sitostanol是常见植物甾醇sitosterol的一种代谢物，能降低胆固醇的胶束溶解度。 | ||||
| GC18544 | 8-dehydro Cholesterol | 70741-38-7 | >95.00% | |
An isomer of 7-DHC | ||||
| GC18567 | β-hydroxy Pyruvic Acid | 1113-60-6 | >98.00% | |
A metabolite in the process of photorespiration | ||||
| GC18583 | D-α-Hydroxyglutaric Acid | 13095-47-1 | >98.00% | |
D-α-Hydroxyglutaric Acid是α-酮戊二酸（α-KG）的弱竞争性拮抗剂（K i = 10.87mM）。 | ||||
| GC18628 | 3-Methylcrotonyl Glycine | 33008-07-0 | >99.00% | |
A metabolite with diverse biological activities | ||||
| GC18646 | Myristelaidic Acid | 50286-30-1 | >98.00% | |
A monounsaturated ω-5 fatty acid | ||||
| GC18663 | Leukotriene C4 | 72025-60-6 | >97.00% / >95.00% | |
The parent cysteinyl leukotriene produced by LTC 4 synthase catalyzed conjugation of glutathione to LTA 4 | ||||
| GC19134 | beta-D-(-)-Arabinose | 10323-20-3 | >98.00% | |
A monosaccharide | ||||