GlpBio

Drug Metabolite

Drug Metabolite(药物代谢物)

Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Drug Metabolite 相关产品(498)

  • GC36058 structure
    GC36058Flumazenil acid
    CAS: 84378-44-9

    Flumazenil acid 是 Flumazenil 的一种代谢产物。Flumazenil 是一种 GABAA 受体拮抗剂。

  • GC36304 structure
    GC36304IMR-1A
    CAS: 331862-41-0
    纯度: >98.00%

    IMR-1A, an acid metabolite of IMR-1, is a potent inhibitor of Notch with IC50 of 0.5 μM and Kd of 2.9 μM. IMR-1A exhibits anti-tumor activity.

  • GC36589 structure
    GC36589Methotrexate metabolite
    CAS: 19741-14-1
    纯度: >98.00%

    Methotrexate metabolite (DAMPA)，是 Methotrexate 的活性代谢产物。 Methotrexate 是一种叶酸 (folic acid) 拮抗剂，广泛用作免疫抑制剂和化学治疗剂。

  • GC36737 structure
    GC36737Nicotinamide N-oxide
    CAS: 1986-81-8
    纯度: >99.50%

    A metabolite of nicotinamide

  • GC37056 structure
    GC37056Quetiapine sulfoxide
    CAS: 329216-63-9

    Quetiapine sulfoxide (Quetiapine S-oxide) 是 Quetiapinem 的主要代谢产物。Quetiapinem 是第二代抗精神病药。

  • GC37057 structure
    GC37057Quetiapine sulfoxide dihydrochloride
    CAS: 329218-11-3
    纯度: >98.50%

    Quetiapine sulfoxide dihydrochloride (Quetiapine S-oxide dihydrochloride) 是 Quetiapinem 的主要代谢产物。Quetiapinem 是第二代抗精神病药。

  • GC37058 structure
    GC37058Quetiapine sulfoxide hydrochloride

    Quetiapine sulfoxide hydrochloride (Quetiapine S-oxide hydrochloride) 是 Quetiapinem 的主要代谢产物。Quetiapinem 是第二代抗精神病药。

  • GC37542 structure
    GC37542Ritonavir metabolite
    CAS: 176655-55-3

    Ritonavir metabolite 是抗病毒抑制剂 Ritonavir 的代谢物。

  • GC37820 structure
    GC37820Trans (2,3)-Dihydrotetrabenazine
    CAS: 171598-74-6

    Trans (2,3)-Dihydrotetrabenazine， 是抗精神病药物Tetrabenazine的体内代谢物，能够抑制囊泡单胺转运体 2 (VMAT2)。

  • GC37830 structure
    GC37830Trimethoprim 3-oxide
    CAS: 27653-67-4

    Trimethoprim 3-oxide 为一种三甲氧苄二氨嘧啶的初级代谢物。

  • GC38382 structure
    GC38382CNDAC hydrochloride
    CAS: 134665-72-8
    纯度: >99.50%

    CNDAC hydrochloride 是可口服试剂 sapacitabine 的代谢物，为核苷酸类似物。

  • GC38660 structure
    GC38660Megestrol
    CAS: 3562-63-8
    纯度: >99.00%

    Megestrol, a synthetic progestin, is approved for the treatment of anorexia, cachexia, or an unexplained significant weight loss in patients with an acquired immunodeficiency syndrome diagnosis. Megestrol acetate (Megace) is one of the first progestational agents to be evaluated for use in the hormonal therapy of advanced breast cancer.

  • GC38779 structure
    GC38779Etilevodopa
    CAS: 37178-37-3

    Etilevodopa (L-Dopa ethyl ester) 是 Levodopa 的前药，在胃肠道中被非特异性酯酶快速水解为 Levodopa 和乙醇。Etilevodopa 用于治疗帕金森病 (PD)。Levodopa 是多巴胺的直接前体，是一种合适的前体药物，有助于中枢神经系统的渗透和传递多巴胺。

  • GC38903 structure
    GC38903Deslanoside
    CAS: 17598-65-1
    纯度: >98.00%

    A cardiac glycoside

  • GC38931 structure
    GC38931N-Desmethyltamoxifen hydrochloride
    CAS: 15917-65-4
    纯度: >99.50%

    N-Desmethyltamoxifen hydrochloride (N-Desmethyl tamoxifen HCl), the primary metabolite of tamoxifen, is an estrogen response modifer and protein kinase C inhibitor with IC50 of 25 ?M.

  • GC39119 structure
    GC39119Isonicotinic acid
    CAS: 55-22-1
    纯度: >98.00%

    Isonicotinic acid (Isoniazid, 4-pyridinecarboxylic acid, p-pyridinecarboxylic acid, 4-Picolinic acid) is a metabolite of isoniazid. It is an isomer of nicotinic acid.

  • GC39251 structure
    GC39251Cinacalcet metabolite M4
    CAS: 104774-87-0

    Cinacalcet metabolite M4 是 Cinacalcet 的代谢物。Cinacalcet 是一种可口服的 Ca receptor (CaR) 激动剂，用于心血管疾病。

  • GC39307 structure
    GC393074-Methylamino antipyrine
    CAS: 519-98-2
    纯度: >98.00%

    An active metabolite of metamizole

  • GC39373 structure
    GC39373Desmethyl ferroquine
    CAS: 903546-18-9
    纯度: >98.00%

    Desmethyl ferroquine (SSR97213) 是 Ferroquine 的主要活性代谢产物。Ferroquine 是一种抗疟剂。Desmethyl ferroquine 显著抑制对 Chloroquine 敏感的和耐 Chloroquine 的恶性疟原虫菌株 P. falciparum。

  • GC39404 structure
    GC39404Mebeverine alcohol
    CAS: 14367-47-6
    纯度: >97.50%

    Mebeverine alcohol是Mebeverine的代谢物。

  • GC39415 structure
    GC39415OR-1896
    CAS: 220246-81-1
    纯度: >98.50%

    OR-1896 是 Levosimendan 的活性长寿代谢产物。OR-1896 是一种高选择性磷酸二酯酶 (PDE III) 抑制剂，是一种功能强大的血管扩张剂。OR-1896 可以打开 ATP 敏感的 K+ 通道，并具有 Ca2+ 致敏作用。OR-1896 可减轻心肌细胞的凋亡，心脏重塑和心肌炎症。

  • GC39611 structure
    GC396113'-Hydroxy Repaglinide
    CAS: 874908-14-2

    3'-Hydroxy Repaglinide 是 Repaglinide 的主要 CYP2C8 代谢产物。Repaglinide 是氨基甲酰甲基苯甲酸 (CMBA) 衍生物，可作用于 II 型糖尿病。

  • GC39757 structure
    GC39757Etilevodopa hydrochloride
    CAS: 39740-30-2
    纯度: >98.50%

    Etilevodopa (L-Dopa ethyl ester) hydrochloride 是 Levodopa 的前药，在胃肠道中被非特异性酯酶快速水解为 Levodopa 和乙醇。Etilevodopa hydrochloride 用于治疗帕金森病 (PD)。Levodopa 是多巴胺的直接前体，是一种合适的前体药物，有助于中枢神经系统的渗透和传递多巴胺。

  • GC39841 structure
    GC398413,4-Dehydro Cilostazol
    CAS: 73963-62-9
    纯度: >98.00%

    An active metabolite of cilostazol