3,4-dehydro Cilostazol is an active metabolite of the PDE3A inhibitor cilostazol .1,2 It is formed from cilostazol by the cytochrome P450 (CYP) isoforms CYP3A4 and CYP2C19.
1.Suri, A., Forbes, W.P., and Bramer, S.L.Effects of CYP3A inhibition on the metabolism of cilostazolClin. Pharmacokinet.37(Suppl 2)61-68(1999) 2.Liu, Y., Shakur, Y., Yoshitake, M., et al.Cilostazol (pletal): A dual inhibitor of cyclic nucleotide phosphodiesterase type 3 and adenosine uptakeCardiovasc. Drug Rev.19(4)369-386(2001)