GlpBio

Potassium Channel

Potassium Channel(钾离子通道)

Potassium channels are voltage-gated ion channels that selectively permeate potassium ion through the excitable membrane. It regulates the release of neurotransmitters, insulin secretion, smooth muscle contraction and heart rate etc.

Potassium Channel 相关产品(302)

  • GC35075 structure
    GC3507520-HETE
    CAS: 79551-86-3
    纯度: >98.00%

    A cytochrome P450 (CYP450) metabolite of arachidonic acid

  • GC35273 structure
    GC35273Ajmaline
    CAS: 4360-12-7
    纯度: >99.50%

    Ajmaline是一种生物碱, 是一种Ia类的抗心律失常药。

  • GC35293 structure
    GC35293Allocryptopine
    CAS: 485-91-6
    纯度: >98.00%

    An isoquinoline alkaloid with antimicrobial activity

  • GC35322 structure
    GC35322Amiodarone
    CAS: 1951-25-3

    Amiodarone (NSC 85442,Amiodar,Amiodarone hydrochloride,Nexterone) HCl is a sodium/potassium-ATPase inhibitor and an autophagy activator, used to treat various types of cardiac dysrhythmias.

  • GC35453 structure
    GC35453Azimilide Dihydrochloride
    CAS: 149888-94-8
    纯度: >98.00% / >97.50%

    A class III antiarrhythmic agent

  • GC35713 structure
    GC35713CLP290
    CAS: 1181083-81-7
    纯度: >99.50%

    A prodrug form of CLP 257

  • GC35991 structure
    GC35991Endoxifen Z-isomer hydrochloride
    CAS: 1032008-74-4
    纯度: >99.00%

    Endoxifen HCl, the active metabolite of Tamoxifen, ia a potent and selective estrogen receptor antagonist. Phase 2.

  • GC36060 structure
    GC36060Flupirtine
    CAS: 56995-20-1

    An activator of Kv7 channels

  • GC36405 structure
    GC36405Kv3 modulator 1
    CAS: 1380696-64-9

    Kv3 modulator 1 是一种 Kv3 电压门控钾通道调节剂，详细信息请参考专利文献 WO2018020263A1 中的化合物 X。Kv3 modulator 1 可用于治疗炎性疼痛。

  • GC36406 structure
    GC36406Kv3 modulator 2
    CAS: 2101321-76-8

    Kv3 modulator 2 (formula (I)) 是一种有效的 Kv3 channels 调节剂，具有止疼活性，用于相关疾病的预防以及治疗，详细信息请参考专利 WO2018109484A1，化合物 formula (I)。

  • GC36407 structure
    GC36407Kv3 modulator 3
    CAS: 1498186-01-8

    Kv3 modulator 3 (Compound 4) 是一种选择性的 Kv3.1/Kv3.2/Kv3.3 channels 调节剂，具有镇痛活性，用于预防或治疗疼痛，详细信息请参考专利 WO2017098254A1，化合物 4。

  • GC36408 structure
    GC36408Kv3 modulator 4
    CAS: 2173375-10-3

    Kv3 modulator 4 是一种 Kv3.1 (pEC50=5.45) 和 Kv3.2 调节剂，详细信息请参考专利 WO2018020263A1，Cyclobutyl structure。

  • GC36618 structure
    GC36618Mitiglinide calcium hydrate
    CAS: 207844-01-7
    纯度: >99.50%

    Mitiglinide Calcium (KAD-1229) is a blood glucose-lowering drugs, stimulating insulin secretion by closing the ATP-sensitive K+ channels in pancreatic beta-cells.

  • GC36629 structure
    GC36629ML365
    CAS: 947914-18-3
    纯度: >98.50%

    A TASK-1 potassium channel blocker

  • GC36849 structure
    GC36849PAP-1
    CAS: 870653-45-5
    纯度: >99.50%

    An inhibitor of K v 1.3 channels

  • GC37062 structure
    GC37062Quinidine hydrochloride monohydrate
    CAS: 6151-40-2
    纯度: >99.50%

    An antiarrhythmic agent

  • GC37628 structure
    GC37628Senicapoc
    CAS: 289656-45-7
    纯度: >99.50%

    An inhibitor of IK Ca 1/K Ca 3.1 channels

  • GC37897 structure
    GC37897Vernakalant
    CAS: 794466-70-9

    Vernakalant (RSD-1235, MK-6621) is a novel, frequency-dependent Na+ channel and early activating K+ channel blocker that selectively prolongs the atrial refractory period.

  • GC37927 structure
    GC37927VU 0240551
    CAS: 893990-34-6
    纯度: >99.50%

    A KCC2 cotransporter inhibitor

  • GC37930 structure
    GC37930VU591
    CAS: 1222810-74-3
    纯度: >99.00%

    VU591 是一种强效的、选择性的肾外髓钾通道 (ROMK 或Kir1.1) 的抑制剂，其 IC50 值为 0.24 μM。

  • GC38048 structure
    GC38048Sigma-1 receptor antagonist 3
    CAS: 1639220-17-9
    纯度: >99.00%

    Sigma-1 receptor antagonist 3 (化合物 135) 是有效的，选择性 Sigma-1 (σ1) 受体拮抗剂，Ki 为 1.14 nM。Sigma-1 receptor antagonist 3 抑制 hERG，IC50 为 1.54μM。Sigma-1 receptor antagonist 3 用于治疗神经性疼痛。

  • GC38200 structure
    GC38200NS13001
    CAS: 1063331-94-1
    纯度: >99.50%

    NS13001 是一种有效的、选择性的、具有口服活性 SK channels (小电导钙激活钾通道) 正向变构调节剂。NS13001 对 SK2 和 SK3 通道的 EC50 分别为 1.8 μM 和 0.14 μM。NS13001 有望作为治疗脊髓小脑共济失调 2 型 (SCA2) 和可能的其他小脑共济失调的潜在治疗剂。

  • GC38223 structure
    GC38223Dihydroberberine
    CAS: 483-15-8
    纯度: >98.00%

    Dihydroberberine是一种强效的haematopoietic prostaglandin D2 synthase (H-PGDS)抑制剂，IC 50 值为3.7μM。

  • GC38391 structure
    GC38391Tipepidine hydrochloride
    CAS: 1449686-84-3
    纯度: >99.50%

    Tipepidine hydrochloride 可逆地抑制多巴胺 D2 受体介导的 GIRK 电流 (IDA(GIRK))，从而激活 VTA 多巴胺神经元， 对 IDA(GIRK) 的 IC50 为 7.0 μM。Tipepidine hydrochloride 是一种非麻醉性镇咳药，具有抗抑郁样作用。