Allocryptopine is an isoquinoline alkaloid that has been found in M. cordata and has antimicrobial activity.1,2,3 It is active against S. aureus, P. aeruginosa, and E. coli (MICs = 250, 125, and 125 ?g/ml, respectively), the protozoa P. falciparum and E. histolytica (IC50s = 5.08 and 135 ?M, respectively), as well as a panel of seven phytopathogenic fungi, including F. graminearum and F. oxysporum, with IC50 values ranging from 15.2 to 42.4 ?g/ml.
1.Kosina, P., Gregorova, J., Gruz, J., et al.Phytochemical and antimicrobial characterization of Macleaya cordata herbFitoterapia81(8)1006-1012(2010) 2.Wright, C.W., Marshall, S.J., Russell, P.F., et al.In vitro antiplasmodial, antiamoebic, and cytotoxic activities of some monomeric isoquinoline alkaloidsJ. Nat. Prod.63(12)1638-1640(2000) 3.Liu, H., Wang, J., Zhao, J., et al.Isoquinoline alkaloids from Macleaya cordata active against plant microbial pathogensNat. Prod. Commun.4(11)1557-1560(2009)