iGluR
iGluR(离子型谷氨酸受体)
iGluR (ionotropic glutamate receptor) is a ligand-gated ion channel that is activated by the neurotransmitter glutamate. iGluR are integral membrane proteins compose of four large subunits that form a central ion channel pore. Sequence similarity among all known glutamate receptor subunits, including the AMPA, kainate, NMDA, and δ receptors.
AMPA receptors are the main charge carriers during basal transmission, permitting influx of sodium ions to depolarise the postsynaptic membrane. NMDA receptors are blocked by magnesium ions and therefore only permit ion flux following prior depolarisation. This enables them to act as coincidence detectors for synaptic plasticity. Calcium influx through NMDA receptors leads to persistent modifications in the strength of synaptic transmission.
iGluR 相关产品(155)
- GC30212(S)-Willardiine ((-)-Willardiine)CAS: 21416-43-3纯度: >99.00% / >99.50%
(S)-Willardiine ((-)-Willardiine)是一种强效的AMPA/kainate受体激动剂，EC 50 值为45μM。
- GC30457Zonampanel (YM 872)CAS: 210245-80-0纯度: >98.00%
Zonampanel (YM 872) (YM 872) 是谷氨酸受体亚型 α；-氨基-3-羟基-5-甲基异恶唑-4-丙酸 (AMPA) 受体的选择性拮抗剂。
- GC30774Tat-NR2B9cCAS: 500992-11-0纯度: >98.00%
Tat-NR2B9c 旨在通过阻止突触后密度蛋白 95 (PSD-95) 与 N-甲基-D-天冬氨酸 (NMDA) 受体和神经元一氧化氮结合来阻止一氧化氮 (NO) 的产生氧化物合成酶。
- GC30788L-Glutamic acid monosodium salt (Monosodium glutamate)CAS: 142-47-2纯度: >98.00% / >99.50%
L-Glutamic acid monosodium salt is the sodium salt of glutamic acid, found naturally in tomatoes, cheese and other foods. L-Glutamic acid monosodium salt acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). (S)-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals.
- GC30835Rislenemdaz (MK-0657)CAS: 808732-98-1纯度: >99.50%
Rislenemdaz (MK-0657) (CERC-301) 是一种口服生物可利用的选择性 N-甲基-D-天冬氨酸 (NMDA) 受体亚基 2B (GluN2B) 拮抗剂，其 Ki 和 IC 50 分别为 8.1 nM 和 3.6 nM。
- GC30839TraxoprodilCAS: 134234-12-1纯度: >99.00%
An antagonist of NR2B subunit-containing NMDA receptors
- GC30911Apimostinel (NRX-1074)CAS: 1421866-48-9纯度: >99.00%
Apimostinel (NRX-1074) (NRX-1074; AGN-241660) 是一种具有口服活性的 NMDA 受体部分激动剂。
- GC30946Procyclidine hydrochloride ((±)-Procyclidine hydrochlorid)CAS: 1508-76-5纯度: >99.00%
A muscarinic acetylcholine receptor antagonist
- GC30973MephenesinCAS: 59-47-2纯度: >98.00%
Mephenesin (Decontractyl, Cresoxydiol, Memphenesin, Mephedan) is centrally acting muscle relaxant, a topical analgesic and may be an NMDA receptor antagonist.
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC18033 | γDGG | 6729-55-1 | - | |
γDGG 是一种竞争性 AMPA 受体阻滞剂。 | ||||
| GC18079 | CFM-2 | 178616-26-7 | >98.50% | |
CFM-2 是一种有效且选择性的非竞争性 AMPAR 拮抗剂。 | ||||
| GC18118 | SDZ 220-581 | 174575-17-8 | >99.00% | |
SDZ 220-581 是一种具有口服活性、强效、竞争性 NMDA 受体拮抗剂，pKi 值为 7.7。 | ||||
| GC18223 | Farampator | 211735-76-1 | >99.50% | |
A positive allosteric modulator of AMPA receptors | ||||
| GC18410 | Ro 25-6981 (maleate) | 1312991-76-6 | - | |
A potent, NR2B-selective NMDA receptor antagonist | ||||
| GC19310 | Ro 25-6981 | 169274-78-6 | - | |
A potent, NR2B-selective NMDA receptor antagonist | ||||
| GC19346 | Talampanel | 161832-65-1 | >98.00% | |
An allosteric AMPA receptor antagonist | ||||
| GC30212 | (S)-Willardiine ((-)-Willardiine) | 21416-43-3 | >99.00% / >99.50% | |
(S)-Willardiine ((-)-Willardiine)是一种强效的AMPA/kainate受体激动剂，EC 50 值为45μM。 | ||||
| GC30457 | Zonampanel (YM 872) | 210245-80-0 | >98.00% | |
Zonampanel (YM 872) (YM 872) 是谷氨酸受体亚型 α；-氨基-3-羟基-5-甲基异恶唑-4-丙酸 (AMPA) 受体的选择性拮抗剂。 | ||||
| GC30774 | Tat-NR2B9c | 500992-11-0 | >98.00% | |
Tat-NR2B9c 旨在通过阻止突触后密度蛋白 95 (PSD-95) 与 N-甲基-D-天冬氨酸 (NMDA) 受体和神经元一氧化氮结合来阻止一氧化氮 (NO) 的产生氧化物合成酶。 | ||||
| GC30788 | L-Glutamic acid monosodium salt (Monosodium glutamate) | 142-47-2 | >98.00% / >99.50% | |
L-Glutamic acid monosodium salt is the sodium salt of glutamic acid, found naturally in tomatoes, cheese and other foods. L-Glutamic acid monosodium salt acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). (S)-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals. | ||||
| GC30818 | ZL006 | 1181226-02-7 | >98.00% | |
An nNOS/PSD-95 interaction inhibitor | ||||
| GC30835 | Rislenemdaz (MK-0657) | 808732-98-1 | >99.50% | |
Rislenemdaz (MK-0657) (CERC-301) 是一种口服生物可利用的选择性 N-甲基-D-天冬氨酸 (NMDA) 受体亚基 2B (GluN2B) 拮抗剂，其 Ki 和 IC 50 分别为 8.1 nM 和 3.6 nM。 | ||||
| GC30839 | Traxoprodil | 134234-12-1 | >99.00% | |
An antagonist of NR2B subunit-containing NMDA receptors | ||||
| GC30847 | IC87201 | 866927-10-8 | - | |
An inhibitor of the nNOS-PSD-95 protein-protein interaction | ||||
| GC30852 | Org-26576 | 1026791-61-6 | >99.50% | |
Org26576是AMPA受体的正变构调节剂。 | ||||
| GC30860 | Neu2000 | 640290-67-1 | >98.50% | |
Neu2000 (Salfaprodil free base) 是 N-甲基-D-天冬氨酸 (NMDA) 的 NR2B 选择性和非竞争性拮抗剂。 | ||||
| GC30911 | Apimostinel (NRX-1074) | 1421866-48-9 | >99.00% | |
Apimostinel (NRX-1074) (NRX-1074; AGN-241660) 是一种具有口服活性的 NMDA 受体部分激动剂。 | ||||
| GC30946 | Procyclidine hydrochloride ((±)-Procyclidine hydrochlorid) | 1508-76-5 | >99.00% | |
A muscarinic acetylcholine receptor antagonist | ||||
| GC30951 | MDL 105519 | 161230-88-2 | - | |
MDL105519是有效和选择性的甘氨酸与NMDA受体结合的拮抗剂。 | ||||
| GC30973 | Mephenesin | 59-47-2 | >98.00% | |
Mephenesin (Decontractyl, Cresoxydiol, Memphenesin, Mephedan) is centrally acting muscle relaxant, a topical analgesic and may be an NMDA receptor antagonist. | ||||
| GC31019 | GV-196771A | 166974-23-8 | - | |
GV-196771A是GV196771的钠盐形式。是NMDA受体拮抗剂。 | ||||
| GC31036 | MRZ 2-514 | 202808-11-5 | - | |
MRZ2-514是一种NMDAreceptor(glycineB)的拮抗剂，Ki值为33μM。 | ||||
| GC31039 | RPR104632 | 154106-92-0 | - | |
RPR104632是一种特异性的NMDAreceptor拮抗剂，具有神经保护的作用。 | ||||