GlpBio

iGluR

iGluR(离子型谷氨酸受体)

iGluR (ionotropic glutamate receptor) is a ligand-gated ion channel that is activated by the neurotransmitter glutamate. iGluR are integral membrane proteins compose of four large subunits that form a central ion channel pore. Sequence similarity among all known glutamate receptor subunits, including the AMPA, kainate, NMDA, and δ receptors.

AMPA receptors are the main charge carriers during basal transmission, permitting influx of sodium ions to depolarise the postsynaptic membrane. NMDA receptors are blocked by magnesium ions and therefore only permit ion flux following prior depolarisation. This enables them to act as coincidence detectors for synaptic plasticity. Calcium influx through NMDA receptors leads to persistent modifications in the strength of synaptic transmission.

iGluR 相关产品(155)

  • GC31076 structure
    GC31076GNE 5729
    CAS: 2026635-66-3
    纯度: >98.50%

    GNE5729是一种可透过血脑屏障的NMDAR的正向调节剂，对GluN2A的EC50值为37nM，对GluN2C和GluN2D的EC50值分别为4.7和9.5μM。

  • GC31153 structure
    GC31153UK-240455
    CAS: 178908-09-3

    UK-240455是一个有效且有选择性的N-甲基D-天冬氨酸(NMDA)甘氨酸位点上的拮抗剂。

  • GC31270 structure
    GC31270GNE 0723
    CAS: 1883518-31-7
    纯度: >98.50% / >97.00%

    GNE 0723是一种选择性作用于GluN2A亚基且能穿透血脑屏障的N-甲基-D-天冬氨酸受体（NMDAR）正向变构调节剂（PAM），其半数有效浓度（EC 50 ）为0.021μM，最大增强作用为152%。

  • GC31309 structure
    GC313096-Methoxy-2-naphthoic acid (Naproxen impurity O)
    CAS: 2471-70-7
    纯度: >98.00%

    An active metabolite of nabumetone

  • GC32447 structure
    GC32447Transcrocetinate disodium (Disodium trans-crocetinate)
    CAS: 591230-99-8

    从藏红花 (Crocus sativus L.) 中提取的 Transcrocetinate disodium (Disodium trans-crocetinate) 作为 NMDA 受体拮抗剂具有高亲和力。

  • GC32553 structure
    GC32553CNS-5161 hydrochloride (CNS 5161A)
    CAS: 160756-38-7

    CNS-5161 hydrochloride (CNS 5161A) 是一种新型 NMDA 离子通道拮抗剂，可与 NMDA 受体/离子通道位点相互作用，对谷氨酸的作用产生非竞争性阻断。

  • GC32755 structure
    GC32755DNQX (FG 9041)
    CAS: 2379-57-9
    纯度: >98.00%

    A non- NMDA glutamate receptor antagonist

  • GC33341 structure
    GC33341Transcrocetin (trans-Crocetin)
    CAS: 27876-94-4
    纯度: >98.00%

    A natural apocarotenoid with diverse biological activities

  • GC33492 structure
    GC33492Rapastinel Trifluoroacetate (GLYX-13 Trifluoroacetate)
    CAS: 1435786-04-1
    纯度: >98.00%

    A partial agonist of the NMDA receptor

  • GC33668 structure
    GC33668Naspm (1-Naphthylacetyl spermine)
    CAS: 122306-11-0

    Naspm (1-Naphthylacetyl semimine) (1-Naphthyl acetyl semimine) 是 Joro 蜘蛛毒素的合成类似物，是一种钙渗透性 AMPA (CP-AMPA) 受体拮抗剂。

  • GC33673 structure
    GC3367324-Hydroxycholesterol
    CAS: 30271-38-6
    纯度: >98.00%

    24-Hydroxycholesterol是一种天然的固醇类物质，是n-甲基-d-天门冬氨酸受体(NMDA)和转录因子LXR的激活剂。

  • GC33685 structure
    GC33685Tulrampator (CX-1632)
    CAS: 1038984-31-4
    纯度: >99.00%

    Tulrampator (CX-1632) (CX-1632) 是一种口服生物可利用的阳性 AMPAR（AMPA 受体的变构调节剂）。

  • GC33701 structure
    GC33701Orphenadrine hydrochloride
    CAS: 341-69-5

    A muscarinic acetylcholine receptor antagonist

  • GC33723 structure
    GC33723Becampanel (AMP 397)
    CAS: 188696-80-2

    Becampanel (AMP 397) (AMP397) 是第一个竞争性 AMPA 拮抗剂和抗癫痫剂。

  • GC33740 structure
    GC33740NT 13 (TPPT)
    CAS: 117928-93-5

    NT 13 (TPPT) (TPPT) 是一种四肽，具有氨基酸序列 L-苏氨酰-L-脯氨酰-L-脯氨酰-L-苏氨酸酰胺。

  • GC34352 structure
    GC34352NMDAR antagonist 1
    CAS: 2220162-06-9

    NMDAR antagonist 1 is a potent and orally bioavailable NR2B-selective antagonist of NMDAR. It has neuroprotective activity.

  • GC34638 structure
    GC34638JNJ-61432059
    CAS: 2035814-50-5
    纯度: >99.00%

    JNJ-61432059是具有口服活性的、选择性的AMPAR的负向调节剂，其对GluA1/γ-8的pIC50值为9.7。在老鼠的海马体中显示出具有时间和剂量依赖性的AMPA受体占用情况，在角膜点燃癫痫动物模型中显示出较强的保护作用。

  • GC34753 structure
    GC34753Radiprodil
    CAS: 496054-87-6
    纯度: >99.00%

    An NMDA receptor antagonist

  • GC34828 structure
    GC34828Tat-NR2B9c TFA
    CAS: 1834571-04-8
    纯度: >99.50%

    Tat-NR2B9c(TFA)是由20个氨基酸组成的多肽，为PSD-95的抑制剂，对PSD-95d2和PSD-95d1的EC50值分别为6.7nM和670nM。Tat-NR2B9c同时可降低NMDA诱导的p38的活化，具有神经保护作用。

  • GC34998 structure
    GC34998(S)-(-)-5-Fluorowillardiine hydrochloride
    CAS: 1321546-70-6
    纯度: >99.50%

    (S)-(-)-5-Fluorowillardiine hydrochloride 是AMPAR高效选择性激动剂。

  • GC35917 structure
    GC35917Dynorphin A (1-10) TFA
    纯度: >99.00%

    Dynorphin A (1-10) (TFA) 是一种内源性的阿片样神经肽，与 κ 阿片受体 (κ-opioid receptor) 结合。Dynorphin A (1-10) (TFA) 也阻断 NMDA 激活的电流，IC50 为 42.0 μM。

  • GC35918 structure
    GC35918Dynorphin A 1-10
    CAS: 79994-24-4

    Dynorphin A (1-10) 是一种内源性的阿片样神经肽，与 κ 阿片受体 (κ-opioid receptor) 结合。Dynorphin A (1-10) 也阻断 NMDA 激活的电流，IC50 为 42.0 μM。

  • GC36027 structure
    GC36027Fanapanel hydrate
    CAS: 1255517-78-2
    纯度: >99.50%

    Fanapanel hydrate (ZK200775 hydrate) 是高选择性AMPA拮抗剂。

  • GC36060 structure
    GC36060Flupirtine
    CAS: 56995-20-1

    An activator of Kv7 channels