DNQX (FG 9041)

DNQX is a competitive, non-NMDA glutamate receptor antagonist (IC₅₀s = 0.5 and 0.1 μM for AMPA and kainate receptors, respectively versus IC₅₀ = 40 μM for NMDA receptors).^1,2,3 This compound has been used to specifically target AMPA and kainate receptor responses and thus differentiate from that of NMDA receptors. DNQX does not stimulate a robust long-term potentiation in the hippocampus.⁴

1.Armstrong, N., and Gouaux, E.Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: Crystal structures of the GluR2 ligand binding coreNeuron28(1)165-181(2000) 2.Honoré, T., Davies, S.N., Drejer, J., et al.Quinoxalinediones: Potent competitive non-NMDA glutamate receptor antagonistsScience241(4866)701-703(1988) 3.Lee, S.H., Govindaiah, G., and Cox, C.L.Selective excitatory actions of DNQX and CNQX in rat thalamic neuronsJ. Neurophysiol.103(4)1728-1734(2010) 4.Muller, D., Joly, M., and Lynch, G.Contributions of quisqualate and NMDA receptors to the induction and expression of LTPScience242(4886)1694-1697(1988)