GlpBio

iGluR

iGluR(离子型谷氨酸受体)

iGluR (ionotropic glutamate receptor) is a ligand-gated ion channel that is activated by the neurotransmitter glutamate. iGluR are integral membrane proteins compose of four large subunits that form a central ion channel pore. Sequence similarity among all known glutamate receptor subunits, including the AMPA, kainate, NMDA, and δ receptors.

AMPA receptors are the main charge carriers during basal transmission, permitting influx of sodium ions to depolarise the postsynaptic membrane. NMDA receptors are blocked by magnesium ions and therefore only permit ion flux following prior depolarisation. This enables them to act as coincidence detectors for synaptic plasticity. Calcium influx through NMDA receptors leads to persistent modifications in the strength of synaptic transmission.

iGluR 相关产品(155)

  • GC13684 structure
    GC13684S 18986
    CAS: 175340-20-2

    A positive allosteric modulator of AMPA receptors

  • GC13728 structure
    GC13728SYM 2206
    CAS: 173952-44-8
    纯度: >99.50%

    SYM 2206 是一种有效的非竞争性 AMPA 受体拮抗剂，IC50 为 1.6 μM。

  • GC13779 structure
    GC13779Orphenadrine Citrate
    CAS: 4682-36-4
    纯度: >98.00%

    Orphenadrine citrate 是一种具有口服活性且非竞争性的 NMDA 受体拮抗剂（穿过血脑屏障），Ki 为 6.0 μM。

  • GC14039 structure
    GC14039MDL-29951
    CAS: 130798-51-5
    纯度: >99.50%

    An NMDA receptor antagonist and GPR17 agonist

  • GC14121 structure
    GC14121GLYX 13
    CAS: 117928-94-6

    A partial agonist of the NMDA receptor

  • GC14156 structure
    GC14156NBQX
    CAS: 118876-58-7
    纯度: >98.50% / >98.00%

    NBQX是一种高度选择性和竞争性的AMPA受体拮抗剂。

  • GC14414 structure
    GC14414CIQ
    CAS: 486427-17-2
    纯度: >98.00%

    A subunit-selective NMDA receptor potentiator

  • GC14492 structure
    GC14492PF 4778574
    CAS: 1219633-99-4

    PF 4778574 是 AMPA 受体的正向变构调节剂，在不同细胞中的 EC50 为 45 至 919 nM。

  • GC14495 structure
    GC14495CX 546
    CAS: 215923-54-9
    纯度: >99.00%

    CX 546是一种强效的3-羟基-5-甲基-4-异唑丙酸（AMPA）受体激活剂，EC 50 值为93.2μM。

  • GC14533 structure
    GC14533Kynurenic acid
    CAS: 492-27-3
    纯度: >99.00% / >98.00%

    Kynurenic acid 是一种内源性色氨酸代谢物，是一种针对 NMDA、谷氨酸、α7 烟碱乙酰胆碱受体的广谱拮抗剂。

  • GC14547 structure
    GC14547Quinolinic acid
    CAS: 89-00-9
    纯度: >99.00%

    An excitotoxic agonist at NMDA receptors

  • GC14810 structure
    GC14810L-701,324
    CAS: 142326-59-8
    纯度: >99.50%

    An NMDA receptor antagonist

  • GC14842 structure
    GC14842GYKI 53655 hydrochloride
    CAS: 143692-48-2
    纯度: >98.00%

    GYKI 53655 (LY300168) hydrochloride 是一种 α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) 拮抗剂。

  • GC15343 structure
    GC15343Eliprodil
    CAS: 119431-25-3
    纯度: >98.50%

    An NMDA receptor antagonist

  • GC15363 structure
    GC15363Felbamate hydrate
    CAS: 1177501-39-1

    An inhibitor of NMDA receptors and a modulator of GABA A receptors

  • GC16101 structure
    GC16101SYM 2081
    CAS: 31137-74-3

    SYM 2081 是一种高亲和力配体和有效的红藻氨酸受体激动剂，抑制 [3H]-红藻氨酸结合，IC50 为 35 nM，对红藻氨酸受体的选择性分别是 AMPA 和 NMDA 受体的近 3000 倍和 200 倍[1 ]。

  • GC16149 structure
    GC16149Topiramate
    CAS: 97240-79-4
    纯度: >98.00%

    Topiramate是一种口服有效的磺胺衍生单糖，具有广谱抗癫痫活性。

  • GC16300 structure
    GC16300ZK 200775
    CAS: 161605-73-8
    纯度: >99.00%

    ZK 200775 (ZK200775) 是一种高度选择性的 AMPA/红藻氨酸拮抗剂，对 NMDA 几乎没有活性； Ki 值分别为 3.2 nM、100 nM 和 8.5 μ；M 分别针对 quisqualate、红藻氨酸和 NMDA。

  • GC16315 structure
    GC16315D-AP5
    CAS: 79055-68-8
    纯度: >98.00%

    D-AP5是一种选择性N-甲基-D-天门冬胺酸（NMDA）受体拮抗剂，K d 值为1.4μM。

  • GC16562 structure
    GC16562PEAQX
    CAS: 459836-30-7
    纯度: >98.00%

    PEAQX是一种强效且有口服活性的NMDA受体拮抗剂，对hNMDA 1A/2A和1A/2B受体的IC 50 值分别为0.270μM和29.6μM。

  • GC16776 structure
    GC16776QNZ 46
    CAS: 1237744-13-6
    纯度: >98.00%

    An antagonist of NR2C- and NR2D-subunit containing NMDA receptors

  • GC16899 structure
    GC16899Coluracetam
    CAS: 135463-81-9
    纯度: >98.00%

    An Analytical Reference Standard

  • GC16986 structure
    GC16986SDZ 220-581 hydrochloride
    CAS: 179411-93-9
    纯度: >99.50%

    SDZ 220-581 hydrochloride 是一种口服有效的竞争性 NMDA 受体拮抗剂，pKi 值为 7.7。

  • GC17456 structure
    GC17456NMDA (N-Methyl-D-aspartic acid)
    CAS: 6384-92-5
    纯度: >98.00%

    An excitatory neurotransmitter