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Home >> Signaling Pathways >> Neuroscience >> COX

COX(环氧合酶)

COX (cyclooxygenase) is an enzyme that is responsible for formation of important biological mediators called prostanoids, including prostaglandins, prostacyclin and thromboxane.

Products for  COX

  1. Cat.No. 产品名称 Information
  2. GC16508 Salicylic acid

    水杨酸; 2-Hydroxybenzoic acid

     An Analytical Reference Standard
  3. GC74187 Salicylic acid-13C6

    2-Hydroxybenzoic acid-13C6

     Salicylic acid-13C6是13c标记的水杨酸。
  4. GC49480 Salicylic Acid-d4

    水杨酸-D4

     An internal standard for the quantification of salicylic acid
  5. GC64032 Salicylic acid-d6

    水杨酸-D6; 2-Hydroxybenzoic acid-d6

     Salicylic acid-D6 (2-Hydroxybenzoic acid-D6) 是 Salicylic acid 的一种氘代化合物。Salicylic acid 抑制 COX-2 活性，抑制作用与转录因子 (NF-κB) 激活无关。
  6. GC49363 Salicyluric Acid

    2-羟基马尿酸

     A major metabolite of aspirin and salicylic acid
  7. GC10973 SC 236

    4-(5-(4-氯苯基)-3-(三氟甲基)-1H-

     A potent, selective COX-2 inhibitor
  8. GC15634 SC 560

    5-(4-氯苯基)-1-(4-甲氧基苯基)-3-(三氟甲基)-1H-吡唑

     A selective inhibitor of COX-1
  9. GC17817 SC 58125

    1-[(4-甲基磺酰基)苯基]-3-三氟甲基-5-(4-氟苯基)吡唑

     A selective COX-2 inhibitor
  10. GC31960 SC57666

    SC57666是选择性的COX2抑制剂，IC50值为26nM。
  11. GC31985 SC58451 SC58451是一个强效的，有选择性的COX-2抑制剂。
  12. GC12013 Sodium salicylate

    水杨酸钠; Salicylic acid sodium salt; 2-Hydroxybenzoic acid sodium salt

     水杨酸钠（水杨酸钠盐）抑制环加氧酶 2（COX-2）活性，与转录因子（NF-κB）激活无关。
  13. GC60345 Sphondin

    牛防风素

     Sphondin可从Heracleumlaciniatum中分离，对IL-1β诱导的A549细胞中COX-2蛋白和PGE2释放水平的升高具有抑制作用。
  14. GC64940 Sudoxicam

    舒多昔康

     Sudoxicam 是一种可逆的口服活性的 COX 拮抗剂，是烯醇-羧酰胺类的非甾体抗炎药 (NSAID)。Sudoxicam 具有有效的抗炎，抗浮肿和退热作用。
  15. GC16716 Sulindac

    舒林酸; MK-231

     A non-selective COX inhibitor
  16. GC15059 Sulindac sulfide

    cis-Sulindac sulfide

     An active metabolite of sulindac
  17. GC11721 Sulindac sulfone

    磺基舒林,Exisulind

     A metabolite of sulindac
  18. GC48677 Sulindac-d3

    MK-231-d3

     An internal standard for the quantification of sulindac
  19. GC31440 Syringaldehyde

    丁香醛

     A polyphenol with diverse biological activities
  20. GC39040 Taraxerol acetate

    醋酸蒲公英霜

     Taraxerol acetate 是 COX-1 和 COX-2 抑制剂， IC50 值分别为 116.3 μM 和 94.7μM。Taraxerol acetate 具有抗癌作用并诱导细胞凋亡(apoptosis)。
  21. GC64025 Tazofelone

    LY 213829

     Tazofelone (LY 213829) 是一种环氧合酶-II (COX-II) 抑制剂。Tazofelone 转化为亚砜和喹啉代谢物主要由 CYP3A 介导。Tazofelone 可用于炎症性肠病的研究。
  22. GC11853 Tenidap

    替尼达普,CP-66248

     A COX-1 selective NSAID
  23. GC10006 Tenoxicam

    替诺昔康; Ro-12-0068

     An NSAID and COX-1 inhibitor
  24. GC49386 Tepoxalin

    替泊沙林

     A dual inhibitor of COX and 5-LO
  25. GC61764 Teriflunomide impurity 3

    4-Amino-N-(4-trifluoromethylphenyl)benzamide

     Teriflunomideimpurity3(4-Amino-N-(4-trifluoromethylphenyl)benzamide)是一种选择性COX-1抑制剂，IC50为30µM，对COX-2的活性较低(IC50>100µM)。
  26. GC19353 TFAP

    N-(5-Aminopyridin-2-yl)-4-(trifluoromethyl)benzamide

     A selective COX-1 inhibitor
  27. GC31826 Thioflosulide (L-745337)

    L-745337

     Thioflosulide (L-745337) (L-745337) 是一种选择性 cyclooxygenase-2 (COX2) 抑制剂，IC50 为 2.3 nM，具有抗炎活性。
  28. GC45579 Tiaprofenic Acid

    噻洛芬酸

     A COX inhibitor and NSAID
  29. GC31956 Tilmacoxib (JTE522)

    替马考昔; JTE522; JTP19605; RWJ57504

     Tilmacoxib (JTE522) (JTE522) 是一种高度选择性、时间依赖性和不可逆的人 COX-2 抑制剂，在酶试验中 IC50 为 85 nM。
  30. GC31965 Timegadine (SR1368)

    替美加定; SR1368

     Timegadine (SR1368) 是一种新型抗炎剂，被发现是一种有效的、竞争性的环加氧酶 (COX) 和脂加氧酶抑制剂，IC50 范围为 5 nM（洗涤过的兔血小板）至 20 μM（大鼠脑） ) 用于 COX 和 100 μ；M 用于马血小板匀浆的胞质溶胶部分和洗涤过的兔血小板中的脂加氧酶。
  31. GC15395 Tolfenamic Acid

    托芬那酸; GEA 6414

     An NSAID with anticancer activity
  32. GC45965 Tolfenamic Acid-d4

    托芬那酸 D4

     An internal standard for the quantification of tolfenamic acid
  33. GC61337 Tolmetin

    托麦汀；托美丁

     Tolmetin (Tolectin) is a nonsteroidal anti-inflammatory drug of the heterocyclic acetic acid derivative class and also exhibits analgesic and antipyretic activity.
  34. GC16428 Tolmetin (sodium salt hydrate)

    痛灭定

     A non-selective NSAID
  35. GC13300 Triflusal

    三氟柳

     An inhibitor of platelet aggregation
  36. GC13402 Tryptanthrin

    色胺酮,NSC 349447

     An alkaloid with diverse actions
  37. GC14020 Valdecoxib

    伐地考昔; SC 65872

     A COX-2 inhibitor
  38. GC48232 Valdecoxib-d3

    戊地昔布-D3,SC 65872-d3

     An internal standard for the quantification of valdecoxib
  39. GC10335 Valeroyl Salicylate

    戊酰基水杨酸,2-Valeryloxybenzoic Acid

     A selective, irreversible inhibitor of COX-1
  40. GC61371 Veratric acid

    藜芦酸

     Veratricacid(3,4-Dimethoxybenzoicacid)是从蔬菜和水果中得到的多酚物质，可口服，具有抗氧化、保护心血管和抗炎活性。当细胞受到UVB辐射时，Veratricacid能够减少上调的COX-2表达，降低PGE2和IL-6水平。
  41. GC33632 Veratric acid (3,4-Dimethoxybenzoic acid)

    藜芦酸; 3,4-Dimethoxybenzoic acid

     Veratric acid (3,4-Dimethoxybenzoic acid), a simple benzoic acid derived from plants and fruits, has anti-oxidant, anti-inflammation, and blood pressure-lowering effects. Veratric acid reduces upregulated COX-2 expression, and levels of PGE2, IL-6 after UVB irradiation.
  42. GC12391 Xanthohumol

    黄腐醇

    A natural prenylated chalcone
  43. GC13626 Zaltoprofen

    扎托布洛芬; CN100

     A non-selective COX inhibitor
  44. GC11203 ZLJ-6 Dual inhibitor of cyclooxygenase/5-lipoxygenase
  45. GC63267 α-​Chaconine

    阿尔法卡茄碱

     α-Chaconine 可在转录水平抑制 COX-2，IL-1β，IL-6 和 TNF-α 表达。α-Chaconine 作用于 RAW 264.7 巨噬细胞，在蛋白和 mRNA 水平上抑制 LPS 诱导的 iNOS 和 COX-2 表达及其启动子活性。α-Chaconine 具有抗炎作用。

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