GlpBio

COX

COX(环氧合酶)

COX (cyclooxygenase) is an enzyme that is responsible for formation of important biological mediators called prostanoids, including prostaglandins, prostacyclin and thromboxane.

COX 相关产品(291)

  • GC32026 structure
    GC32026Naproxen etemesil (LT-NS 001)
    CAS: 385800-16-8
    纯度: >99.50%

    Naproxen etemesil (LT-NS 001) 是一种亲脂性、非酸性、无活性的萘普生前药，一旦被吸收就会水解成具有药理活性的萘普生。

  • GC32030 structure
    GC32030COX2-IN-1
    CAS: 134729-13-8

    COX2-IN-1是选择性的，诱导型的COX2抑制剂，IC50值为0.24μM。COX2-IN-1是具有抗炎和止痛活性的抗炎物。

  • GC32640 structure
    GC32640Pamicogrel (KBT3022)
    CAS: 101001-34-7
    纯度: >99.00%

    A COX inhibitor and an antiplatelet agent

  • GC32841 structure
    GC32841Catechin ((+)-Catechin)
    CAS: 154-23-4
    纯度: >99.00%

    (+)-Catechin (Cianidanol, Catechinic acid, Catechuic acid) is an antioxidant flavonoid, occurring especially in woody plants as both (+)-catechin and (-)-epicatechin (cis) forms.

  • GC32957 structure
    GC32957(-)-Catechin gallate ((-)-Catechin 3-gallate)
    CAS: 130405-40-2
    纯度: >98.00%

    A polyphenol with diverse biological activities

  • GC33484 structure
    GC33484Ampyrone (4-Aminoantipyrine)
    CAS: 83-07-8

    4-Aminoantipyrine(Ampyrone) is a metabolite of aminopyrine with analgesic, anti-inflammatory, and antipyretic properties. It is used as a reagent for biochemical reactions producing peroxides or phenols.

  • GC33632 structure
    GC33632Veratric acid (3,4-Dimethoxybenzoic acid)
    CAS: 93-07-2

    Veratric acid (3,4-Dimethoxybenzoic acid), a simple benzoic acid derived from plants and fruits, has anti-oxidant, anti-inflammation, and blood pressure-lowering effects. Veratric acid reduces upregulated COX-2 expression, and levels of PGE2, IL-6 after UVB irradiation.

  • GC33861 structure
    GC33861Inulicin (1-O-Acetylbritannilactone)
    CAS: 33627-41-7
    纯度: >98.00% / >99.50%

    A sesquiterpene lactone with diverse biological activities

  • GC33876 structure
    GC33876Propyphenazone (4-Isopropylantipyrine)
    CAS: 479-92-5
    纯度: >99.50%

    Propyphenazone(4-Isopropylantipyrine, Isopropyrine), an analgesic and antipyretic agent, is a selective cyclooxygenase-2 inhibitor with anti-inflammatory activity.

  • GC33893 structure
    GC33893FR-188582
    CAS: 189699-82-9
    纯度: >99.00%

    FR-188582是高选择性的环氧合酶(COX-2)抑制剂，IC50值为17nM。

  • GC34028 structure
    GC34028Nitroflurbiprofen (HCT 1206)
    CAS: 158836-71-6

    Nitroflurbiprofen (HCT 1206) 是一种环氧合酶 (COX) 抑制剂，具有提供一氧化氮 (NO) 的特性，可调节门脉高压性肝硬化大鼠肝内血管张力的增加。

  • GC34116 structure
    GC34116Hexahydrocurcumin
    CAS: 36062-05-2
    纯度: >99.50%

    A natural product and an active metabolite of curcumin

  • GC35012 structure
    GC35012[10]-Shogaol
    CAS: 36752-54-2
    纯度: >99.50%

    A phenol with diverse biological activities

  • GC35013 structure
    GC35013[8]-Shogaol
    CAS: 36700-45-5
    纯度: >99.50%

    [8]-Shogaol，生姜中的一种刺激性酚类化合物，具有抗血小板活性 (IC50=5 μM) 和抑制 COX-2 (IC50=17.5 μM)。[8]-Shogaol 诱导人白血病细胞凋亡。

  • GC35493 structure
    GC35493Benzoylgomisin O
    CAS: 130783-32-3

    Benzoylgomisin O 是从 Schisandra rubriflora 中分离的化合物，对 15-LOX、COX-1、COX-2 酶有抑制作用，且具有抗炎活性。

  • GC36014 structure
    GC36014Etoricoxib D4
    CAS: 1131345-14-6
    纯度: >99.00%

    Etoricoxib D4 (MK-0663 D4) 是 Etoricoxib 的氘代标记物。Etoricoxib 是一种非甾体抗炎剂，为可口服的、选择性的 COX-2 抑制剂，对人全血 COX-2 和 COX-1 的 IC50 值分别为 1.1 μM 和 116 μM。

  • GC36200 structure
    GC36200GW-406381
    CAS: 221148-46-5
    纯度: >99.50%

    A NSAID and COX-2 inhibitor

  • GC36305 structure
    GC36305Imrecoxib
    CAS: 395683-14-4
    纯度: >99.50%

    Imrecoxib（BAP-909）艾瑞昔布是选择性环氧合酶 2 (COX-2) 抑制剂，IC50 值为 18 nM，也可以抑制 COX1 活性，IC50 值为 115 nM。Imrecoxib（BAP-909) 艾瑞昔布具有抗炎作用。

  • GC36314 structure
    GC36314Indobufen
    CAS: 63610-08-2
    纯度: >99.50%

    Indobufen (Ibustrin, K 3920) is a reversible platelet aggregation inhibitor. Indobufen is a reversible inhibitor of platelet cyclooxygenase (Cox) activity and suppresses thromboxane synthesis.

  • GC36482 structure
    GC36482Loxoprofen
    CAS: 68767-14-6
    纯度: >99.50%

    An NSAID and a prodrug form of loxoprofen-SRS

  • GC36721 structure
    GC36721Nepafenac D5
    CAS: 1246814-53-8
    纯度: >98.00%

    An internal standard for the quantification of nepafenac

  • GC36747 structure
    GC36747Nitroaspirin
    CAS: 175033-36-0

    Nitroaspirin (NCX 4016) 是一氧化氮 (NO) 供体和阿司匹林的硝基衍生物，Aspirin 与 Nitroaspirin 联合以抑制环加氧酶。Nitroaspirin (NCX 4016) 具有抗血栓形成和抗血小板特性，并作为 COX-1 的直接和不可逆抑制剂。Nitroaspirin (NCX 4016) 通过下调 EGFR/PI3K/STAT3 信号传导和调节 Bcl-2 家族蛋白，在顺铂耐药人卵巢癌细胞中引起细胞周期停滞和凋亡。

  • GC36828 structure
    GC36828Oxaprozin D4

    Oxaprozin D4是Oxaprozin的氘代化合物标准品。

  • GC36852 structure
    GC36852Parecoxib
    CAS: 198470-84-7
    纯度: >98.00%

    A prodrug form of valdecoxib