COX
COX(环氧合酶)
COX (cyclooxygenase) is an enzyme that is responsible for formation of important biological mediators called prostanoids, including prostaglandins, prostacyclin and thromboxane.
COX 相关产品(291)
- GC38151Roburic acidCAS: 6812-81-3纯度: >99.00%
Roburic acid 是秦艽中的四环三萜类化合物，作为一种 COX 的抑制剂，对 COX-1 和 COX-2 的 IC50 值分别为 5 和 9 μM。
- GC38184DehydrodiisoeugenolCAS: 2680-81-1纯度: >98.00%
Dehydrodiisoeugenol（DEH）是香豆蔻中具有代表性的主要苯并呋喃型新木质素，具有抗菌、抗炎、抗癌、抗氧化等特性。
- GC38198Revaprazan hydrochlorideCAS: 178307-42-1纯度: >98.00%
Revaprazan Hydrochloride (YH1885) is a new reversible proton pump inhibitor with long-lasting acid-suppressive effects. Revaprazan Hydrochloride reversibly inhibits H(+)/K(+)-ATPase via binding to the K+-binding site of the pump.
- GC38678Ethyl CaffeateCAS: 102-37-4纯度: >98.50%
Ethyl caffeate, a naturally occurring compound found in Bidens pilosa, suppresses NF-kappaB activation and its downstream inflammatory mediators, iNOS, COX-2 and PGE2 in vitro.
- GC39013FPL 62064CAS: 103141-09-9纯度: >98.00%
FPL 62064 is a potent dual inhibitor of 5-lipoxygenase (5-LOX) and prostaglandin synthetase (cyclooxygenase, COX) with IC50 of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and seminal vesicle prostaglandin synthetase, respectively. FPL 62064 has potent anti-inflammatory activity.
- GC39040Taraxerol acetateCAS: 2189-80-2
Taraxerol acetate 是 COX-1 和 COX-2 抑制剂， IC50 值分别为 116.3 μM 和 94.7μM。Taraxerol acetate 具有抗癌作用并诱导细胞凋亡(apoptosis)。
- GC39134IsofraxidinCAS: 486-21-5纯度: >98.00%
Isofraxidin (6,8-Dimethoxyumbelliferone), a bioactive coumarin compound isolated from the functional foods Siberian ginseng and Apium graveolens, is an anti-bacterial, anti-oxidant, and anti-inflammatory agent.
- GC40065Meloxicam-d3CAS: 942047-63-4纯度: >99.00%
An internal standard for the quantification of meloxicam
- GC40227Indomethacin-d4CAS: 87377-08-0纯度: >99.00%
An internal standard for the quantification of indomethacin
- GC40686N-trans-FeruloyltyramineCAS: 66648-43-9纯度: >98.50%
A phenolic amide with diverse biological activities
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC38066 | Mavacoxib | 170569-88-7 | >98.00% | |
Mavacoxib (Trocoxil) is a selective, long-acting cyclooxygenase-2 (COX-2) inhibitor. Mavacoxib is a novel nonsteroidal anti-inflammatory drug (NSAID). | ||||
| GC38151 | Roburic acid | 6812-81-3 | >99.00% | |
Roburic acid 是秦艽中的四环三萜类化合物，作为一种 COX 的抑制剂，对 COX-1 和 COX-2 的 IC50 值分别为 5 和 9 μM。 | ||||
| GC38184 | Dehydrodiisoeugenol | 2680-81-1 | >98.00% | |
Dehydrodiisoeugenol（DEH）是香豆蔻中具有代表性的主要苯并呋喃型新木质素，具有抗菌、抗炎、抗癌、抗氧化等特性。 | ||||
| GC38198 | Revaprazan hydrochloride | 178307-42-1 | >98.00% | |
Revaprazan Hydrochloride (YH1885) is a new reversible proton pump inhibitor with long-lasting acid-suppressive effects. Revaprazan Hydrochloride reversibly inhibits H(+)/K(+)-ATPase via binding to the K+-binding site of the pump. | ||||
| GC38224 | Crocin II | 55750-84-0 | >98.00% | |
Crocin II (Crocin B, Crocetin gentiobiosylglucosyl ester, Tricrocin), a carotenoid chemical compound that is found in the flowers crocus and gardenia, is an antioxidant and neural protective agent. | ||||
| GC38431 | Dehydroevodiamine | 67909-49-3 | >98.00% | |
An alkaloid with diverse biological activities | ||||
| GC38616 | Hamaudol | 735-46-6 | - | |
Hamaudol 是从 Saposhnikovia divaricata 中分离出的一种色酮。Hamaudol 对环加氧酶 (COX)-1 和 COX-2 的活性具有明显的抑制能力，其 IC50 值分别为 0.30、0.57 mM，并且具有有效的镇痛和抗炎作用。 | ||||
| GC38678 | Ethyl Caffeate | 102-37-4 | >98.50% | |
Ethyl caffeate, a naturally occurring compound found in Bidens pilosa, suppresses NF-kappaB activation and its downstream inflammatory mediators, iNOS, COX-2 and PGE2 in vitro. | ||||
| GC39013 | FPL 62064 | 103141-09-9 | >98.00% | |
FPL 62064 is a potent dual inhibitor of 5-lipoxygenase (5-LOX) and prostaglandin synthetase (cyclooxygenase, COX) with IC50 of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and seminal vesicle prostaglandin synthetase, respectively. FPL 62064 has potent anti-inflammatory activity. | ||||
| GC39040 | Taraxerol acetate | 2189-80-2 | - | |
Taraxerol acetate 是 COX-1 和 COX-2 抑制剂， IC50 值分别为 116.3 μM 和 94.7μM。Taraxerol acetate 具有抗癌作用并诱导细胞凋亡(apoptosis)。 | ||||
| GC39134 | Isofraxidin | 486-21-5 | >98.00% | |
Isofraxidin (6,8-Dimethoxyumbelliferone), a bioactive coumarin compound isolated from the functional foods Siberian ginseng and Apium graveolens, is an anti-bacterial, anti-oxidant, and anti-inflammatory agent. | ||||
| GC39307 | 4-Methylamino antipyrine | 519-98-2 | >98.00% | |
An active metabolite of metamizole | ||||
| GC39534 | Isoxicam | 34552-84-6 | >98.00% | |
Isoxicam 是一种口服有效的非甾体抗炎剂，可用于关节炎的研究。Isoxicam 是一种非选择性的 COX-1 和 COX-2 抑制剂。 | ||||
| GC39583 | Nimesulide D5 | 1330180-22-7 | - | |
An internal standard for the quantification of nimesulide | ||||
| GC40065 | Meloxicam-d3 | 942047-63-4 | >99.00% | |
An internal standard for the quantification of meloxicam | ||||
| GC40227 | Indomethacin-d4 | 87377-08-0 | >99.00% | |
An internal standard for the quantification of indomethacin | ||||
| GC40262 | α-Humulene | 6753-98-6 | >95.00% | |
A sesquiterpene with diverse biological activities | ||||
| GC40352 | Cafestol | 469-83-0 | >98.00% | |
Cafestol是咖啡中主要活性成分之一，是一种咖啡特异性二萜类化合物，具有ERK2抑制活性。 | ||||
| GC40565 | Feprazone | 30748-29-9 | >98.00% | |
A COX-2 inhibitor | ||||
| GC40651 | Oxyphenbutazone | 129-20-4 | >99.00% | |
An NSAID | ||||
| GC40686 | N-trans-Feruloyltyramine | 66648-43-9 | >98.50% | |
A phenolic amide with diverse biological activities | ||||
| GC40842 | (-)-Catechin | 18829-70-4 | >98.00% | |
A diastereoisomer of catechin | ||||
| GC41218 | Guaiacol | 90-05-1 | >99.00% / >98.00% | |
Guaiacol is a phenolic natural product first isolated from Guaiac resin and the oxidation of lignin. | ||||
| GC41389 | (S)-Ketorolac | 66635-92-5 | >99.50% | |
A non-selective COX inhibitor | ||||