Other Apoptosis

An alkaloid with diverse biological activities

A quinolizidine alkaloid with diverse biological activities

An alkaloid with diverse biological activities

Eriosematin 是一种来自 Flemingia philippinensis 的根的化合物，具有抗增殖活性和诱导细胞凋亡的特性。

BTdCPU是一种通过激活血红素调节抑制激酶（HRI）发挥作用的化合物，BTdCPU能够促进eIF2α的磷酸化，诱导细胞凋亡。

Polygalacin D (PGD) 是从桔梗 Platycodon grandiflorum 中分离的具有抗癌和抗增殖特性的生物活性化合物。Polygalacin D 抑制 IAP 蛋白家族的表达，包括存活蛋白，cIAP-1 和 cIAP-2 蛋白，并通过抑制 GSK3β，Akt 的磷酸化和PI3K 的表达来阻断 PI3K/Akt 途径。Polygalacin D 通过 PI3K/Akt 途径诱导凋亡 (apoptosis)。

A flavolignan with diverse biological activities

Ilexsaponin A 是从冬凌草的根中分离出的，通过抗凋亡途径减轻缺血再灌注引起的心肌损伤。Ilexsaponin A 可以减少心肌梗塞的大小，降低 LDH，AST 和 CK-MB 的血清水平，增加细胞活力并抑制缺氧/复氧心肌细胞的凋亡。

A BMI1 inhibitor

Glaucocalyxin A is a biologically active ent-kauranoid diterpenoid isolated from Rabdosia japonica var. glaucocalyx with antitumor and anti-inflammatory activity. Glaucocalyxin A induces G2/M cell cycle arrest and apoptosis through the PI3K/Akt pathway in human bladder cancer cells.

Rotundic acid (Rutundic acid), a natural compound, exhibit cytotoxic activities toward human hepatocellular carcinoma (HepG2), malignant melanoma (A375), SCLC (NCI-H446), breast cancer (MCF-7), and colon cancer (HT-29) cell lines.RA induces cell cycle arrest, DNA damage, and apoptosis by modulating the AKT/mTOR and MAPK pathways.

Dihydrokaempferol（Aromadendrin）是一种天然存在的黄酮类化合物，具有清除自由基、抗炎、抗肿瘤等生物活性。

Dihydrorotenone是一种杀虫剂，是线粒体复合物I的不可逆抑制剂，并且能够穿过血脑屏障。

Selumetinib (AZD6244) 是一种高效选择性的，非 ATP 竞争性的 MEK1/2 抑制剂， 抑制 MEK1 的 IC50 为 14 nM。Selumetinib (AZD6244) 抑制 MEK1/2 磷酸化水平。

Benzyl isothiocyanate (BITC, Benzoylthiocarbimide, Isothiocyanic Acid Benzoyl Ester) is an isothiocyanate originally found in cruciferous vegetables that exhibits immunomodulatory, anti-parasitic, antibiotic, antioxidative, anti-atherosclerotic, anti-angiogenic, anti-metastatic, anticancer chemotherapeutic, and chemopreventive activities.

A FASN inhibitor

DIM-C-pPhOH是一种核受体4A1（NR4A1）拮抗剂，可引起细胞凋亡和细胞应激。

A synthetic monounsaturated hydroxylated fatty acid

A selenium-containing amino acid

An antagonist of PDGFRβ, FLT3, and c- Kit

TK216 is a potent inhibitor targeting E26 transformation specific (ETS) factors via blocking the protein-protein interaction with RNA helicases. TK216 exhibits antilymphoma activity.

TL02-59 is an orally active, selective Src-family kinase Fgr inhibitor with an IC50 of 0.03 nM.

9-ING-41是一种选择性且强效的GSK-3β抑制剂，IC 50 值为0.71μM。

PI-273, the first reversibly and specific phosphatidylinositol 4-kinase (PI4KIIα) inhibitor with an IC50 of 0.47 μM, can inhibit breast cancer cell proliferation, block the cell cycle and induce cell apoptosis.