2-hydroxy Oleic acid is a synthetic monounsaturated hydroxylated fatty acid.1 It decreases the lamellar-to-hexagonal transition temperature of bovine liver phosphatidylethanolamine (PE) membranes by approximately 12.5°C when included at a 20:1 molar ratio of PE:2-hydroxy oleic acid. 2-hydroxy Oleic acid increases levels of protein kinase C α (PKCα) in and decreases proliferation of A549 non-small cell lung cancer (NSCLC) cells in a concentration-dependent manner. It reduces tumor growth in an A549 mouse xenograft model when administered at doses of 75 and 200 mg/kg. 2-hydroxy Oleic acid has been used in the generation of liposomes.2
1.Martínez, J., V?gler, O., Casas, J., et al.Membrane structure modulation, protein kinase Cα activation, and anticancer activity of minervalMol. Pharmacol.67(2)531-540(2004) 2.Olechowska, K., Mach, M., H?c-Wydro, K., et al.Studies on the interactions of 2?hydroxyoleic acid with monolayers and bilayers containing cationic lipid: Searching for the formulations for more efficient drug delivery to cancer cellsLangmuir35(27)9084-9092(2019)