Other Apoptosis(其他细胞凋亡)

Cat.No. 产品名称 Information

GC45213 α-NETA

2-(BETA-萘甲酰基)乙基三甲基碘化铵

An inhibitor of choline acetyltransferase

GC46008 (±)-Thalidomide-d4

沙利度胺 D4

An internal standard for the quantification of (±)-thalidomide

GC45256 (+)-ar-Turmerone

(6S)-2-甲基-6-(4-甲基苯基)-2-庚烯-4-酮,(+)-ar-Turmerone

A natural compound with immunomodulatory activities

GC41345 (-)-α-Bisabolol

没药醇; (-)-α-Bisabolol

A sesquiterpene alcohol with diverse biological activities

GC40698 (-)-Perillyl Alcohol

紫苏醇

A monoterpene alcohol with diverse biological activities

GC34965 (20S)-Protopanaxatriol

20 (S)-原人参三醇; 20(S)-APPT; g-PPT

An active ginsenoside metabolite

GC34125 (E)-[6]-Dehydroparadol (E)-[6]-Dehydroparadol来自专利US9272994化合物M15,能够抑制人体癌细胞生长并且诱导细胞凋亡。在HCT-116和H-1299细胞中的IC50值分别为43.02和41.59μM。

GC34981 (E)-Flavokawain A

卡瓦胡椒素A

A chalcone with diverse biological activities

GN10783 (R) Ginsenoside Rh2

20(R)-人参皂苷Rh2

A steroid glycoside with diverse biological activities

GC15104 (R)-(+)-Etomoxir sodium salt

(R)-(+)-乙莫克舍钠盐,(R)-(+)-Etomoxir sodium salt

(R)-(+)-Etomoxir sodium salt(Etomoxir; ETO)是一种用于代谢和心血管疾病的小分子,经酶转化为活性抑制剂乙托莫西里尔辅酶a (IC50 约为0.01-0.70 µM)后,对CPT-1a和CPT-1b的抑制表现出纳摩尔效价。

GC41716 (R)-CR8

(2R)-2-[[9-异丙基-6-[[[4-(2-吡啶基)苯基]甲基]氨基]-9H-嘌呤-2-基]氨基]-1-丁醇,CR8, (R)-Isomer

An inhibitor of cyclin-dependent kinases

GC19541 (rac)-Antineoplaston A10

3-苯基乙酰氨基-2,6-哌啶二酮

(rac)-Antineoplaston A10 是 Antineoplaston A10 的外消旋体。 Antineoplaston A10 是一种潜在的 Ras 抑制剂，可用于治疗神经胶质瘤、淋巴瘤、星形细胞瘤和乳腺癌。

GC10098 (S)-10-Hydroxycamptothecin

10-羟基喜树碱; 10-HCPT; 10-Hydroxycamptothecin

A DNA topoisomerase I inhibitor

GC11965 (±)-Huperzine A

(±)-石杉碱甲

A neuroprotective AChE inhibitor

GC11988 15-acetoxy Scirpenol

15-乙酰蛇形菌素

A trichothecene mycotoxin

GC11720 17-AAG (KOS953)

坦螺旋霉素; 17-AAG; NSC 330507; CP 127374

17-AAG（格尔德霉素）是一种天然的苯醌安沙霉素抗生素，是第一个确定的 Hsp90 抑制剂。

GC13044 17-DMAG (Alvespimycin) HCl

阿螺旋霉素盐酸盐; 17-DMAG hydrochloride; KOS-1022; BMS 826476

Water-soluble inhibitor of Hsp90

GN10065 2-Atractylenolide

苍术内酯 II; Asterolide

A sesquiterpene with diverse biological activities

GC17430 2-Deoxy-D-glucose

2-脱氧-D-葡萄糖; 2-DG; 2-Deoxy-D-arabino-hexose; D-Arabino-2-deoxyhexose

2-Deoxy-D-glucose (2DG)，是一种葡萄糖类似物，作为竞争性糖酵解抑制剂。

GC38318 2-Methoxycinnamaldehyde

2'-甲氧基肉桂醛,o-Methoxycinnamaldehyde

2-methoxycinnamaldehyde (O-methoxycinnamaldehyde), found in ceylan cinnamon, is a flavouring ingredient.

GC15084 2-Methoxyestradiol (2-MeOE2)

二甲氧基雌二醇; 2-ME2; NSC-659853

2-Methoxyestradiol (2-MeOE2/2-Me)是一种HIF-1α抑制剂。

GN10800 20(S)-NotoginsenosideR2

三七皂苷R2,20(S)-Notoginsenoside R2; Ginsenoside Ng-R2

20(S)-NotoginsenosideR2 是一种从三七中新分离的三七皂苷，对 6-OHDA 诱导的氧化应激和细胞凋亡具有神经保护作用。

GC35112 3'-Hydroxypterostilbene

3’-羟基紫檀茋

3'-Hydroxypterostilbene (3'-HPT) is one of the active constituents of Sphaerophysa salsula and Pterocarpus marsupium which may be useful in treating different types of haematological malignancies. 3'-Hydroxypterostilbene, a natural pterostilbene analogue, effectively inhibits the growth of human colon cancer cells (IC50s of 9.0, 40.2, and 70.9 ?M for COLO 205, HCT-116, and HT-29 cells, respectively) by inducing apoptosis and autophagy. 3'-Hydroxypterostilbene inhibits the PI3K/Akt/mTOR/p70S6K, and p38MAPK pathways and activates the ERK1/2, JNK1/2 MAPK pathways.

GC35106 3-Dehydrotrametenolic acid

3-氢化去氢松苓酸

3-Dehydrotrametenolic acid，分离于茯苓菌核，是一种乳酸脱氢酶 (LDH) 抑制剂。3-Dehydrotrametenolic acid 促进体外脂肪细胞分化，在体内起胰岛素增敏剂的作用。3-Dehydrotrametenolic acid 诱导细胞凋亡，具有抗癌活性。

GC17394 3-Nitropropionic acid

3-硝基丙酸; β-Nitropropionic acid; Bovinocidin

An inhibitor of complex II

GC35099 3-O-Acetyloleanolic acid

齐墩果酸3-乙酸酯

A triterpene with diverse biological activities

GC32767 3BDO

3BDO,MTOR激酶激活剂,自噬抑制剂

A butyrolactone derivative and autophagy inhibitor

GC42346 4-bromo A23187

4-溴代-钙离子载体,4-Bromocalcimycin

A non-fluorescent calcium ionophore

GC30896 4-Hydroxybenzyl alcohol

对羟基苯甲醇

A phenol with diverse biological activities

GC35138 4-Methyldaphnetin

4-甲基瑞香素

7,8-Dihydroxy-4-methylcoumarin (DHMC) is a precursor in the synthesis of derivatives of 4-methyl coumarin, which has excellent radical scavenging properties.

GC10468 4EGI-1

eIF4E/eIF4G Interaction Inhibitor

An inhibitor of mRNA translation

GC35150 5,7,4'-Trimethoxyflavone

5,7,4'-三甲氧基黄酮

4',5,7-Trimethoxyflavone (5,7,4'-Trimethoxyflavone, TMF) is a flavonoid isolated from Kaempferia parviflora (KP) that induces apoptosis. 4',5,7-Trimethoxyflavone increases sub-G1 phase, DNA fragmentation, annexin-V/PI staining and Bax/Bcl-xL ratio, activates caspase-3 and degrades poly (ADP-ribose) polymerase (PARP) protein.

GC35147 5-(N,N-Hexamethylene)-amiloride

阿米洛利,Hexamethylene amiloride; HMA

An amiloride derivative with diverse biological activities

GN10093 6-gingerol

6-姜酚; 6-姜辣素; (S)-(+)-[6]Gingerol; 6-Gingerol

A natural TRP receptor agonist

GC16853 7,8-Dihydroxyflavone

7,8-二羟基黄酮

7,8-Dihydroxyflavone（7,8-二羟基黄酮）是一种高亲和力酪氨酸激酶受体B（TrkB）激动剂，IC₅₀值为0.26μM 。

GC17119 8-Prenylnaringenin

8-异戊烯基柚皮素

A phytoestrogen

GC39152 9-ING-41

Elraglusib

A GSK3β inhibitor

GN10035 9-Methoxycamptothecin

10-甲氧基喜树碱

9-Methoxycamptothecin (MCPT) 分离自 Nothapodytes foetida，通过抑制拓扑异构酶具有抗肿瘤活性。 9-Methoxycamptothecin (MCPT) 在癌症中诱导强烈的 G2/M 期阻滞和细胞凋亡。

GC35013 [8]-Shogaol

8-姜烯酚

[8]-Shogaol，生姜中的一种刺激性酚类化合物，具有抗血小板活性 (IC50=5 μM) 和抑制 COX-2 (IC50=17.5 μM)。[8]-Shogaol 诱导人白血病细胞凋亡。

GC11200 A23187

离子载体(钙镁盐混合物),Calcimycin

A23187自由酸是一种Ca2+离子载体。

GC35216 AAPK-25 AAPK-25 是一种有效选择性的 Aurora/PLK 激酶双重抑制剂，具有抗肿瘤活性。AAPK-25 可引起有丝分裂延迟并阻滞前中期细胞，通过生物标志物组蛋白 H3Ser10 磷酸化反应，随后细胞凋亡激增。AAPK-25 靶向 Aurora-A, -B, -C 的 Kd 值为 23 nM-289 nM，靶向 PLK-1, -2, -3 的 Kd 值为 55-456 nM。

GC13805 Abacavir

阿巴卡韦

阿巴卡韦是一种具有口服活性和竞争性的核苷类逆转录酶抑制剂。

GC35227 ACBI1 ACBI1 is a potent and cooperative PROTAC degrader of SMARCA2, SMARCA4 and PBRM1 with DC50 of 6 nM, 11 nM and 32 nM for SMARCA2, SMARCA4 and PBRM1 in MV-4-11 cells, respectively. ACBI1 is composed of a bromodomain ligand, a linker, and the E3 ubiquitin ligase VHL. ACBI1 induces anti-proliferative effects and apoptosis.