Other Apoptosis(其他细胞凋亡)

Cat.No. 产品名称 Information

GC35458 Bacopaside II

假马齿苋皂苷II

A triterpene glycoside

GN10507 Baohuoside I

宝藿苷 I; Icariin-II; Icariside-II

宝活苷 I 是一种从淫羊藿中分离出来的黄酮类化合物，可作为 CXCR4 抑制剂，下调 CXCR4 表达，诱导细胞凋亡并具有抗肿瘤活性。

GC11572 Bardoxolone methyl

甲基巴多索隆; RTA 402; NSC 713200; CDDO Methyl ester

A synthetic triterpenoid with potent anticancer and antidiabetic activity

GC17195 Bax inhibitor peptide V5

BIP-V5; BAX Inhibiting Peptide V5

A Bax inhibitor

GC10345 Bay 11-7085

(2E)-3-[[4-叔丁基苯基]磺酰基]-2-丙烯腈,BAY 11-7083

An irreversible inhibitor of IκBα phosphorylation

GC13035 Bay 11-7821

BAY 11-7082

Bay 11-7821(BAY 11-7082)是一种IκBα磷酸化和NF-κB抑制剂，选择性且不可逆地抑制TNF-α诱导的IκB-α磷酸化（IC₅₀值约为10μM），并减少NF-κB和粘附分子的表达。Bay 11-7821抑制泛素特异性蛋白酶USP7和USP21，IC₅₀分别为0.19、0.96μM。

GC16389 BAY 61-3606

2-[[7-(3,4-二甲氧基苯基)咪唑并[1,2-C]嘧啶-5-基]氨基]-3-吡啶甲酰胺,BAY61-3606

A Syk inhibitor

GC12136 BAY 61-3606 dihydrochloride

BAY61-3606 dihydrochloride;BAY 61-3606

BAY 61-3606 dihydrochloride 是一种可口服的、ATP 竞争性、可逆和高选择性的 Syk 抑制剂，Ki 为 7.5 nM，IC50 为 10 nM。

GC16516 BCH

2-氨基-2-去甲菠烷羧酸,2-amino-2-Norbornanecarboxylic Acid

An inhibitor of LAT1

GC10744 Bendamustine HCl

盐酸苯达莫司汀; SDX-105

A DNA alkylating agent

GC14930 Benzbromarone

苯溴马隆

An inhibitor of URAT1

GN10520 Benzoylpaeoniflorin

苯甲酰芍药苷

苯甲酰芍药苷是一种来自中国白芍的天然产物，可通过减少细胞凋亡来治疗冠心病。

GC38683 Benzyl isothiocyanate

苄基异硫氰酸酯

Benzyl isothiocyanate (BITC, Benzoylthiocarbimide, Isothiocyanic Acid Benzoyl Ester) is an isothiocyanate originally found in cruciferous vegetables that exhibits immunomodulatory, anti-parasitic, antibiotic, antioxidative, anti-atherosclerotic, anti-angiogenic, anti-metastatic, anticancer chemotherapeutic, and chemopreventive activities.

GN10358 Berbamine hydrochloride

盐酸小檗胺

A bisbenzylisoquinoline alkaloid with diverse biological activities

GN10539 Bergenin

岩白菜素; Cuscutin

A glycoside with diverse biological activities

GC35504 Beta-Zearalanol

B-赤霉醇

Beta-Zearalanol 是由镰刀菌属 Fusarium 产生的一种霉菌毒素，可以在哺乳动物生殖细胞中引起细胞凋亡 (apoptosis) 和氧化应激反应。 Beta-Zearalanol 是玉米赤霉烯酮（ZEA）的衍生物，可以与葡萄糖醛酸 (glucuronic acid) 结合。

GN10632 Betulin

白桦脂醇; Trochol

An inhibitor of SREBP-driven cholesterol biosynthesis

GC10480 Betulinic acid

白桦脂酸; Lupatic acid; Betulic acid

白桦脂酸（Betulinic acid）是一种天然的五环三萜类化合物，是真核细胞拓扑异构酶I的抑制剂，IC₅₀值为5μM。

GC12074 BG45 A selective HDAC3 inhibitor

GC12450 BI 2536

BI-2536;BI2536

BI 2536是一种双重Polo样激酶（PLK）/溴结构域抑制剂，在无细胞激酶实验中，BI 2536 对PLK1、PLK2和PLK3的半数抑制浓度（IC₅₀）值分别为0.83nM、3.5nM和9.0nM。

GC17828 BI-847325 A selective dual MEK/Aurora kinase inhibitor

GC11224 BI6727(Volasertib)

伏拉塞替; BI 6727

A polo-like kinase inhibitor

GC13636 BIBR 1532

2-[[(2E)-3-(2-萘基)-1-氧代-2-丁烯基]氨基]苯甲酸

A potent telomerase inhibitor

GC14233 BIO-acetoxime

6-溴靛玉红-3'-丙酮肟,BIA

A potent, selective inhibitor of GSK3α/β

GC12426 Birinapant (TL32711)

比瑞那帕; TL32711

Birinapant (TL32711) 是一种 SMAC 模拟物，旨在专门针对 cIAP1 和 cIAP2 进行降解。

GN10037 Bisdemethoxycurcumin

双去甲氧基姜黄素; (E,E)-Curcumin III; (E,E)-Didemethoxycurcumin

Natural curcuminoid with roles in Alzheimer’s, cancer, and inflammation

GC35530 BJE6-106

B106

BJE6-106 (B106) 是一种有效的选择性 PKCδ 抑制剂，IC50 值为 0.05 μM，BJE6-106 (B106) 靶向 PKCδ 的选择性是 PKC 同工酶 PKCα 的 1000倍 (IC50=50 μM)。BJE6-106 (B106) 可以诱导 caspase 依耐性细胞凋亡 (apoptosis)。BJE6-106 (B106) 具有肿瘤特异性作用。

GC11931 BKM120

BKM-120,Buparlisib,BKM 120,NVP-BKM120,NVP-BKM-120

An inhibitor of class I PI3K isoforms

GC12822 BML-210(CAY10433)

NphenylN'(2Aminophenyl)hexamethylenediamide, CAY10433

A potent, synthetic HDAC inhibitor

GC11648 BML-277

Chk2 Inhibitor II

A selective DNA damage control kinase inhibitor

GC16762 BMS-202

PD1-PDL1抑制剂2, PD-1/PD-L1 inhibitor 2

BMS-202是一种非肽性PD-1/PD-L1复合物抑制剂，与PD-L1隔离PD-1/PD-L1二聚体形成（IC₅₀=53.6nM），以结合阻断人PD-1/PD-L1相互作用，从而抑制免疫反应抑制，从而阻止癌细胞逃避抗肿瘤免疫反应。

GC13628 BMS-833923

BMS 833923;BMS833923;XL-139;XL139;XL 139

An orally bioavailable Smo inhibitor

GC16774 Boc-D-FMK

(3S)-3-[[叔丁氧羰基]氨基]-5-氟-4-氧代-戊酸甲酯,Caspase Inhibitor III, Boc-Asp(OMe)-FMK, Boc-D(OMe)-FMK, Caspase3-Inhibitor BOC-D-FMK, Boc-Asp(OMe)-fluoromethylketone

An irreversible pan-caspase inhibitor

GC33501 Bornyl acetate

(-)-乙酸龙脑酯; L-(-)-Bornyl acetate

An acetate form of borneol

GC11040 Borrelidin

疏螺旋体素,Treponemycin

An antiangiogenic antibiotic

GC17644 Bortezomib (PS-341)

硼替佐米; PS-341; LDP-341; NSC 681239

Bortezomib (PS-341) 作为一种具有抗肿瘤活性的二肽硼酸蛋白酶体抑制剂,可通过靶向苏氨酸残基,有效抑制Ki为0.6 nM的20S蛋白酶体。

GC11632 Brassinolide

油菜素内酯; Brassin lactone

Brassinolide是一种植物甾醇，最初从油菜（Brassica napus L.）花粉中分离出来，在植物生长、发育和逆境耐受性方面发挥重要作用。

GN10802 Brazilin

巴西苏木素

A flavonoid with diverse bioactivites

GC35554 Brevilin A

短叶老鹳草素A

A sesquiterpene lactone with anticancer activity

GC35555 Britannin

旋覆花内酯

Britannin，分离于 Inula aucheriana，是倍半萜内酯。Britannin 通过激活由 ROS 调节的 AMPK 来诱导肝癌细胞凋亡和自噬。Britannin 具有抗增殖和抗炎活性。

GC35559 Bruceine D

鸦胆子苦素D

Bruceine D, isolated from Brucea javanica (L.) Merr. (Simaroubaceae), shows antineoplastic properties in various human cancers including pancreas, breast, lung, blood, bone, and liver. Bruceine D induces apoptosis in human chronic myeloid leukemia K562 cells via mitochondrial pathway.

GC38467 BTdCPU BTdCPU is a potent activator of heme regulated inhibitor kinase (HRI), one of eukaryotic translation initiation factor 2α kinases (eIF2α-kinases).

GC34511 BTR-1 BTR-1 induces cytotoxicity in a time- and concentration-dependent manner on leukemia cell line CEM. BTR-1 affects DNA replication by inducing a block at S phase and leads to activation of apoptosis to induce cell death.