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Home >> Signaling Pathways >> Apoptosis >> Other Apoptosis

Other Apoptosis(其他细胞凋亡)

  1. Cat.No. 产品名称 Information
  2. GC16772 Cortisone acetate

    醋酸可的松; Cortisone 21-acetate

     A synthetic glucocorticoid
  3. GC16116 Costunolide

    木香烃内酯; (+)-Costunolide; Costus lactone

     A natural sesquiterpene lactone
  4. GC15225 COTI-2 An activator of mutant forms of p53
  5. GC13091 CP-724714

    2-甲氧基-N-[(2E)-3-[4-[[3-甲基-4-[(6-甲基-3-吡啶基)氧基]苯基]氨基]-6-喹唑啉基]-2-丙烯-1-基]乙酰胺

     A selective HER2/ErbB2 tyrosine kinase inhibitor
  6. GC14699 CPI-203 A bioavailable inhibitor of BET bromodomains
  7. GC10021 CPI-360 A selective EZH2 inhibitor
  8. GC14921 CPI-613

    6,8-双(苄硫基)辛酸,CPI-613

     An inhibitor of α-ketoglutarate dehydrogenase
  9. GC35747 Crebanine

    克班宁

     An aporphine alkaloid with diverse biological activities
  10. GC34543 cRIPGBM cRIPGBM是RIPGBM的促凋亡衍生物，是通过与受体相互作用蛋白激酶2(RIPK2)结合，诱导GBM肿瘤干细胞凋亡的选择性诱导剂，对GBM-1细胞的EC50值为68nM。
  11. GN10535 Cucurbitacin B

    葫芦素 B

    A natural triterpene
  12. GC35758 Cucurbitacin IIa

    葫芦素IIA,Hemslecin A

     Curcurbitacin IIA (Cucurbitacin Iia, CuIIa, Hemslecin A, Dihydrocucurbitacin Q1) is the major active component of the Helmseya amabilis root and is known to have antiviral and anti-inflammatory effects.
  13. GN10788 Cucurbitacin Ⅱb

    雪胆素乙

     A natural triterpene
  14. GC12115 CUDC-907

    CUDC-907

     CUDC 是一种口服生物可利用的小分子 PI3K 和 HDAC 双重抑制剂，作用于 PI3K α 和 HDAC1 / 2 / 3 / 10，IC50 分别为 19 nm 和 1.7 nm / 5 nm / 1.8 nm / 2.8 nm .在 WSU DLCL2 细胞中评估了双功能 HDAC 和 PI3K 抑制剂 CUDC-907 的抗肿瘤活性。
  15. GC11217 CUR 61414

    G-856

     A potent inhibitor of hedgehog-induced activity
  16. GN10521 Curcumol

    姜黄醇; (-)-Curcumol

     A sesquiterpene alcohol with diverse biological activities
  17. GC38419 Cyclovirobuxine D

    黄杨碱

     An alkaloid with diverse biological activities
  18. GC33779 Cysteamine (β-Mercaptoethylamine)

    巯基乙胺

     2-Aminoethanethiol (cysteamine, β-Mercaptoethylamine, 2-Mercaptoethylamine, Thioethanolamine, Mercaptamine) is a radiation-protective agent that oxidizes in air to form cystamine.
  19. GC13502 Cysteamine HCl

    半胱胺盐酸盐; 2-Aminoethanethiol hydrochloride; 2-Mercaptoethylamine hydrochloride

     A radioprotective aminothiol
  20. GC17050 CYT387

    莫洛替尼,Cyt-387,MOMELOTINIB,CYT 387,CYT 11387

     A potent inhibitor of JAK1 and JAK2
  21. GC11383 CYT997 (Lexibulin)

    CYT-997

     An inhibitor of microtubule polymerization
  22. GC13070 Cytarabine

    阿糖胞苷; Cytosine β-D-arabinofuranoside; Cytosine Arabinoside; Ara-C

     Cytarabine（Ara-C）是一种胞嘧啶类似物，主要抑制DNA聚合酶的功能来阻断DNA合成。
  23. GC12256 D-Mannitol

    D-甘露醇 ; Mannitol; Mannite

     An Analytical Reference Standard
  24. GC13202 D4476

    4-[4-(2,3-二氢-1,4-苯并二氧杂环己-6-基)-5-(2-吡啶基)-1H-咪唑-2-基]苯甲酰胺,Casein Kinase I Inhibitor;D 4476;D-4476

     Inhibitor of CK1 and ALK5
  25. GC14485 Dacarbazine

    达卡巴嗪; Imidazole Carboxamide

     A DNA alkylating prodrug
  26. GC10225 Dacomitinib (PF299804, PF299)

    达克替尼; PF-00299804; PF-299804

     A pan-ErbB receptor tyrosine kinase inhibitor
  27. GC15211 Damnacanthal Damnacanthal 是一种从海巴戟根中分离出来的蒽醌。
  28. GN10318 Danshensu

    丹参素

     A salvianolic acid with diverse biological activities
  29. GC17650 DAPK Substrate Peptide A DAPK1 peptide substrate
  30. GC12942 DAPT (GSI-IX)

    gamma-Secretase Inhibitor IX, DAPT, GSI-IX

     DAPT (GSI-IX) 是一种具有口服活性的 γ-分泌酶抑制剂，对人原代神经元培养物中产生的总淀粉样蛋白-β (Aβ) 和 Aβ42 的 IC50 分别为 115 nM 和 200 nM。
  31. GC15568 Dasatinib (BMS-354825)

    达沙替尼; BMS-354825

     Dasatinib (BMS-354825)是一种高效、口服生物利用度高的多靶点酪氨酸激酶抑制剂，对BCR-ABL、SRC家族激酶、c-KIT和PDGFR-β的IC₅₀分别为0.4nM、0.5nM、100nM和180nM。
  32. GC35812 Dasatinib hydrochloride

    达沙替尼盐酸盐; BMS-354825 hydrochloride

     An inhibitor of Abl and Src
  33. GC10354 Daunorubicin HCl

    盐酸柔红霉素; Daunomycin hydrochloride; RP 13057 hydrochloride; Rubidomycin hydrochloride

     Daunorubicin HCl是一种天然来源的蒽环类抗生素，通过嵌入DNA双链并抑制拓扑异构酶Ⅱ活性，阻断DNA复制与转录，从而诱导肿瘤细胞凋亡。
  34. GC38182 Dauricine

    蝙蝠葛碱

     Dauricine, a plant metabolite isolated from the Asian vine Menispermum dauricum, plays a variety of biological roles in the human body, from inhibiting cancer cell growth to blocking cardiac transmembrane Na+, K+, and Ca2+ ion currents.Dauricine induces apoptosis, inhibits proliferation and invasion through inhibiting NF‐κB signaling pathway in colon cancer cells.
  35. GC10824 DBeQ

    JRF 12

     A selective inhibitor of the ATPase p97
  36. GC32719 dBET6 A PROTAC that drives BRD4 degradation
  37. GC19485 DC661 A PPT1 inhibitor
  38. GC16795 DCA

    二氯乙酸钠

     DCA 是癌细胞中的代谢调节剂'；具有抗癌活性的线粒体。 DCA 抑制 PDHK，导致肿瘤微环境中的乳酸减少。 DCA 增加活性氧 (ROS) 生成并促进癌细胞凋亡。 DCA 也可作为 NKCC 抑制剂。
  39. GC14007 DCC-2036 (Rebastinib)

    N-[3-叔丁基-1-(喹啉-6-基)-1H-吡唑-5-基]-N'-[2-氟-4-[(2-(甲基氨基甲酰基)吡啶-4-基)氧]苯基]脲,DCC-2036

     An orally bioavailable tyrosine kinase inhibitor
  40. GC15255 Decitabine(NSC127716, 5AZA-CdR)

    地西他滨; 5-Aza-2'-deoxycytidine; 5-AZA-CdR; NSC 127716

     地西他滨(Decitabine, DAC)是一种具有口服生物活性的脱氧胞苷类似物抗代谢物,具有DNA甲基转移酶抑制剂的功能。
  41. GC35829 Dehydroaltenusin

    脱氢阿霉素

     Dehydroaltenusin 脱氢阿霉素是真核DNA 聚合酶 α (DNA polymerase α) 的小分子选择性抑制剂，一种由真菌产生的抗生素，其 IC50值为 0.68 μM。 Dehydroaltenusin 对哺乳动物 polα 活性的抑制作用模式对 DNA 模板引物 (Ki=0.23 μM) 是竞争性的，对 2'-脱氧核糖核苷 5'-三磷酸底物是非竞争性的 (Ki=0.18 μM)。Dehydroaltenusin 在 S 期阻止癌细胞周期并触发凋亡 apoptosis。Dehydroaltenusin 在体内具有抗人类腺癌肿瘤的抗肿瘤活性。
  42. GC35834 Dehydroeffusol

    去氢厄弗酚

     Dehydroeffusol 是一种来自草药 Juncus effuses 的菲。Dehydroeffusol 通过选择性诱导肿瘤抑制性内质网应激和中度凋亡来抑制胃癌细胞生长和致瘤性。Dehydroeffusol 显示出非常低的毒性。
  43. GC16214 DEL-22379

    N-[2,3-二氢-3-[(5-甲氧基-1H-吲哚-3-基)亚甲基]-2-氧代-1H-吲哚-5-基]-1-哌啶丙酰胺

     An inhibitor of ERK dimerization
  44. GN10529 Demethoxycurcumin

    去甲氧基姜黄素; Curcumin II; Desmethoxycurcumin; Monodemethoxycurcumin

     Natural curcuminoid with roles in cancer and inflammation
  45. GC38160 Demethylzeylasteral

    去甲泽拉木醛

     Demethylzeylasteral是从传统中药雷公藤中提取的三萜类化合物。
  46. GC38564 Deoxypodophyllotoxin

    脱氧鬼臼毒素

     A flavolignan with diverse biological activities
  47. GC16077 Deracoxib

    地拉考昔; SC 046; SC 46; SC 59046

     An NSAID and selective COX-2 inhibitor
  48. GC34157 Desacetylcinobufotalin (Deacetylcinobufotalin)

    去乙酰华蟾蜍它灵,Deacetylcinobufotalin

     Desacetylcinbufotalin (Deacetylcinbufotalin) 是一种天然化合物；凋亡诱导剂，对HepG2细胞有明显抑制作用，IC50值为0.0279μ；mol/ml。
  49. GC38221 Desoxyrhaponticin

    脱氧土大黄苷

     Desoxyrhaponticin (DC, DES), a stilbene glycoside from Rheum tanguticum Maxim. ex Balf. (rhubarb) which is a traditional Chinese nutritional food, is a fatty acid synthase (FAS/FASN) inhibitor. Desoxyrhaponticin (DC, DES) is also a competitive inhibitor of glucose uptake with IC50 of 148.3 μM and 30.9 μM in rabbit intestinal membrane vesicles and in rat everted gut sleeves, respectively. Desoxyrhaponticin has apoptotic effect on human cancer cells.
  50. GC10661 Destruxin B

    黑僵菌素 B

     An insecticidal mycotoxin
  51. GC43439 Diallyl Trisulfide

    二烯丙基三硫化物

     A natural H2S donor

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