Sophoradin is a quinolizidine alkaloid that has been found in S. alopecuroides and has diverse biological activities.1,2,3 It reduces viral titers in primary neonatal rat cardiomyocytes infected with coxsackievirus B3 (CVB3) when used at concentrations of 1 and 5 ?g/ml.2 Sophoradin inhibits the growth of, and induces apoptosis in, SW480 colorectal cancer cells, as well as reduces tumor growth in an SW480 mouse xenograft model.1 It reduces increases in TNF-α, IL-8, and prostaglandin E2 levels in the inflammatory exudate in a mouse model of carrageenan-induced paw edema when administered at doses of 12.15 and 48.6 mg/kg.3
1.Liang, L., Wang, X.-Y., Zhang, X.-H., et al.Sophoridine exerts an anti-colorectal carcinoma effect through apoptosis induction in vitro and in vivoLife Sci.91(25-26)1295-1303(2012) 2.Zhang, Y., Zhu, H., Ye, G., et al.Antiviral effects of sophoridine against coxsackievirus B3 and its pharmacokinetics in ratsLife Sci.78(17)1998-2005(2006) 3.Huang, X., Li, B., and Shen, L.Studies on the anti-inflammatory effect and its mechanisms of sophoridineJ. Anal. Methods Chem.502626(2014)