GlpBio

SARS-CoV

SARS-CoV(SARS冠状病毒)

SARS-CoV (SARS coronavirus) is the virus that causes severe acute respiratory syndrome (SARS). Coronaviruses encode papain-like proteases (PLpro) that are often multifunctional enzymes with protease activity to process the viral replicase polyprotein and deubiquitinating (DUB)/deISGylating activity, which is hypothesized to modify the innate immune response to infection.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease (COVID-19) is the epidemic and the challenge. COVID-19 is similar to the CoV circulating in Rhinolophus, with a 98.7% nucleotide similarity to the partial RNA dependent RNA polymerase gene of the bat coronavirus strain BtCoV/4991 and 87.9% nucleotide similarity to bat coronavirus strain bat-SL-CoVZC45 and bat-SL-CoVZXC21. Remdesivir and Chloroquine are promising agents against COVID-19.

SARS-CoV 相关产品(158)

  • GC15736 structure
    GC15736Rosuvastatin Calcium
    CAS: 147098-20-2
    纯度: >99.50%

    Rosuvastatin Calcium是一种竞争性HMG-CoA还原酶抑制剂，IC 50 值为11nM。

  • GC16359 structure
    GC16359Rosuvastatin
    CAS: 287714-41-4

    Rosuvastatin是一种竞争性HMG-CoA还原酶抑制剂，IC 50 值为11nM。

  • GC17303 structure
    GC17303Ritonavir
    CAS: 155213-67-5
    纯度: >99.50%

    An HIV protease inhibitor

  • GC17439 structure
    GC17439Ledipasvir
    CAS: 1256388-51-8
    纯度: >99.50%

    An HCV NS5A inhibitor

  • GC17709 structure
    GC17709Nelfinavir
    CAS: 159989-64-7
    纯度: >98.50% / >99.00%

    Nelfinavir是一种选择性的、非肽类的HIV-1蛋白酶竞争性抑制剂。Nelfinavir对HIV-1病毒株显示出良好的体外活性。

  • GC17903 structure
    GC17903Atovaquone
    CAS: 95233-18-4
    纯度: >99.50%

    Atovaquone是泛醌的羟基-1,4-萘醌类似物，也称为辅酶Q10（CoQ10）。

  • GC17942 structure
    GC17942Darunavir Ethanolate
    CAS: 635728-49-3
    纯度: >99.50%

    An HIV-1 protease inhibitor

  • GC35144 structure
    GC351444'-O-Methylbavachalcone
    CAS: 20784-60-5
    纯度: >95.00% / >98.00%

    4'-O-Methylbavachalcone 是从补骨脂中分离得到的查尔酮类，可抑制严重急性呼吸综合征冠状病毒 (SARS-CoV) 木瓜样蛋白酶 (PLpro) 的活性，IC50 值为 10.1 μM。

  • GC36939 structure
    GC36939PLpro inhibitor
    CAS: 1093070-14-4
    纯度: >98.00%

    A SARS-CoV PL pro inhibitor

  • GC37020 structure
    GC37020Prulifloxacin
    CAS: 123447-62-1
    纯度: >98.00%

    A prodrug from of ulifloxacin

  • GC39172 structure
    GC39172GRL0617
    CAS: 1093070-16-6
    纯度: >99.50%

    GRL0617是一种选择性的、竞争性非共价的严重急性呼吸综合征冠状病毒木瓜样蛋白酶（SARS-CoV PLpro）抑制剂，其IC₅₀值为0.6μM，Kᵢ值为0.49μM。

  • GC39317 structure
    GC39317(S)-Tenofovir
    CAS: 147127-19-3

    (S)-Tenofovir ((S)-GS 1278) 是 Tenofovir 的低活性 S 型异构体。Tenofovir 是一种核苷酸逆转录酶 (nucleotide reverse transcriptase) 抑制剂，可用于治疗 HIV 和慢性乙型肝炎 (Hepatitis B; HBV)。

  • GN10633 structure
    GN10633Scutellarein
    CAS: 529-53-3
    纯度: >99.50%

    A natural flavone with diverse biological activities

  • GC19549 structure
    GC19549Chloroquine
    CAS: 54-05-7
    纯度: >98.00%

    氯喹是一种抗疟疾和抗炎剂，广泛用于治疗疟疾和类风湿性关节炎。