HY-17542 is an inhibitor of the severe acute respiratory syndrome coronavirus (SARS-CoV) papain-like protease (PLpro; IC50 = 2.6 ?M).1 It increases the viability of SARS-CoV-infected Vero E6 cells (EC50 = 13.1 ?M).
1.Ratia, K., Pegan, S., Takayama, J., et al.A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replicationProc. Natl. Acad. Sci. USA105(42)16119-16124(2008)