GlpBio

SARS-CoV

SARS-CoV(SARS冠状病毒)

SARS-CoV (SARS coronavirus) is the virus that causes severe acute respiratory syndrome (SARS). Coronaviruses encode papain-like proteases (PLpro) that are often multifunctional enzymes with protease activity to process the viral replicase polyprotein and deubiquitinating (DUB)/deISGylating activity, which is hypothesized to modify the innate immune response to infection.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease (COVID-19) is the epidemic and the challenge. COVID-19 is similar to the CoV circulating in Rhinolophus, with a 98.7% nucleotide similarity to the partial RNA dependent RNA polymerase gene of the bat coronavirus strain BtCoV/4991 and 87.9% nucleotide similarity to bat coronavirus strain bat-SL-CoVZC45 and bat-SL-CoVZXC21. Remdesivir and Chloroquine are promising agents against COVID-19.

SARS-CoV 相关产品(158)

  • GC72460 structure
    GC72460Romlusevimab
    CAS: 2509447-08-7
    纯度: 95.00%

    Romlusevimab（BRII-198）是一种针对严重急性呼吸综合征冠状病毒2（SARS-CoV-2）刺突蛋白的中和重组人IgG1单克隆抗体。

  • GC73289 structure
    GC73289SARS-CoV-2 nsp3-IN-1
    CAS: 2892105-43-8
    纯度: >98.00%

    SARS-CoV-2 nsp3-IN-1（化合物15c）是一种Mac1（严重急性呼吸系统综合征冠状病毒2型nsp3大结构域）抑制剂，IC50值为6.1μM。

  • GC73539 structure
    GC73539SARS-CoV-2-IN-46
    纯度: >99.00%

    SARS-CoV-2-IN-46是一种新型冠状病毒（SARS-CoV-2）复制抑制剂，在Calu-3细胞中的EC50为0.9 μM。

  • GC73665 structure
    GC73665Arbemnifosbuvir
    CAS: 1998705-63-7
    纯度: >99.00%

    Arbemnifosbuvir是一种尼迪病毒ddrp相关核苷基转移酶（NiRAN）非结构蛋白12 （nsp12）结构域的干扰药物。

  • GC73677 structure
    GC73677Olgotrelvir sodium
    CAS: 2763596-72-9
    纯度: >95.00%

    Olgotrelvir sodium是一种口服活性的冠状病毒主要蛋白酶（Mpro）和人细胞组织蛋白酶（cathepsin L）的双重抑制剂。

  • GC73745 structure
    GC73745Jun12682
    纯度: >99.00%

    Jun12682是严重急性呼吸系统综合征冠状病毒2型木瓜蛋白酶样蛋白酶的抑制剂。

  • GC74458 structure
    GC74458Pemivibart
    纯度: >99.00%

    Pemivibart是一种抗sars - cov -2人IgG1 λ2单克隆抗体。

  • GC18413 structure
    GC18413EIDD-2801
    CAS: 2349386-89-4
    纯度: >98.00%

    A prodrug form of EIDD-1931

  • GC10295 structure
    GC10295Chloroquine diphosphate
    CAS: 50-63-5
    纯度: >99.50% / >98.00%

    An aminoquinoline

  • GC10317 structure
    GC10317Lamivudine
    CAS: 134678-17-4
    纯度: >98.00%

    Lamivudine是一种口服核苷类似物，作为核苷类逆转录酶抑制剂，抗乙肝病毒（HBV）活性的EC 50 值为0.07±0.02μg/ml。

  • GC10959 structure
    GC10959Boceprevir
    CAS: 394730-60-0
    纯度: >98.00%

    An NS3/4A protease inhibitor

  • GC11655 structure
    GC11655Moexipril HCl
    CAS: 82586-52-5
    纯度: >98.00%

    A prodrug form of moexiprilat

  • GC12116 structure
    GC12116Pitavastatin Calcium
    CAS: 147526-32-7
    纯度: >99.00%

    An HMG-CoA reductase inhibitor

  • GC12301 structure
    GC12301Mizoribine
    CAS: 50924-49-7
    纯度: >98.50%

    An imidazole nucleoside with immunosuppressive properties

  • GC12544 structure
    GC12544Hydroxychloroquine Sulfate
    CAS: 747-36-4
    纯度: >99.50%

    Hydroxychloroquine Sulfate是一种合成的4-氨基喹啉衍生物类抗疟药。

  • GC12635 structure
    GC12635Clevudine
    CAS: 163252-36-6
    纯度: >99.00%

    An antiviral nucleoside analog

  • GC12828 structure
    GC12828Daunorubicin
    CAS: 20830-81-3

    Daunorubicin是一种天然来源的蒽环类抗生素，通过嵌入DNA双链并抑制拓扑异构酶Ⅱ活性，阻断DNA复制与转录，从而诱导肿瘤细胞凋亡。

  • GC12879 structure
    GC12879Danoprevir (RG7227)
    CAS: 850876-88-9
    纯度: >99.50%

    An HCV NS3/4A protease inhibitor

  • GC13197 structure
    GC13197Praziquantel
    CAS: 55268-74-1
    纯度: >99.50% / >98.00%

    An anthelmintic agent

  • GC13716 structure
    GC13716Lopinavir
    CAS: 192725-17-0
    纯度: >99.50% / >99.00%

    A potent HIV-1 protease inhibitor

  • GC14250 structure
    GC14250Bepotastine Besilate
    CAS: 190786-44-8
    纯度: >99.50%

    A histamine H 1 receptor antagonist

  • GC14363 structure
    GC14363Mitoxantrone HCl
    CAS: 70476-82-3
    纯度: >98.00%

    An inhibitor of DNA topoisomerase IIα and HIV-1 integrase

  • GC14366 structure
    GC14366Thioguanine
    CAS: 154-42-7
    纯度: >99.00% / >98.00%

    Thioguanine是一种抗白血病和免疫抑制剂，对重组USP2和冠状病毒PLpro的IC 50 值分别为40μM和25μM。

  • GC15089 structure
    GC15089Carfilzomib (PR-171)
    CAS: 868540-17-4
    纯度: >99.00%

    A proteasome inhibitor