Autophagy
Autophagy(自噬)
Autophagy is a catabolic process which degrades and recycles long-lived proteins and cytoplasmic organelles through lysosome. It plays an important role in growth regulation and maintenance of homeostasis.
Autophagy 相关产品(1140)
- GC33833Tetrahydrocurcumin (HZIV 81-2)CAS: 36062-04-1
A metabolite of curcumin with diverse biological activities
- GC33848Fludrocortisone acetate (9α-Fludrocortisone acetate)CAS: 514-36-3纯度: >99.50%
A mineralocorticoid agonist
- GC34009Nitroprusside disodium dihydrate (Sodium nitroprusside dihydrate)CAS: 13755-38-9纯度: >99.50% / >99.00%
Sodium Nitroprusside Dihydrate is a potent vasodilator working through releasing NO spontaneously in blood.
- GC34010Danshensu (Dan shen suan A)CAS: 76822-21-4纯度: >98.00%
丹参素是丹参的一种活性成分，通过激活 Nrf2 信号通路显示出广泛的心血管益处。
- GC34014Trimetazidine dihydrochlorideCAS: 13171-25-0纯度: >99.50%
Trimetazidine dihydrochloride是一种亲脂性piperazine衍生物，用于治疗心绞痛。
- GC34057TBHQ (tert-Butylhydroquinone)CAS: 1948-33-0纯度: >99.50%
TBHQ(tert-Butylhydroquinone)是一种强效的酚类抗氧化剂，能够减轻氧化应激和炎症反应。
- GC34096(R)-(-)-Gossypol acetic acid (AT-101 (acetic acid))CAS: 866541-93-7纯度: >98.00%
(R)-(-)-Gossypol acetic acid (AT-101 (acetic acid))是一种新型的、具有口服活性的Bcl-2家族蛋白抑制剂，可抑制Bcl-2（K i =260±30nM），Mcl-1（K i =170±10nM）和Bcl-xL（K i =480±40nM）。
- GC34390Autocamtide 2, amide纯度: >99.00%
Autocamtide2,amide是钙调蛋白激酶(CaMK)家族实验的底物(100μMfinalconcentration)。
- GC34532CFTR corrector 2CAS: 1628416-28-3纯度: >99.50%
FDL169 is a CFTR corrector that is designed to fix and restore the function of the defective CFTR protein.
- GC351123'-HydroxypterostilbeneCAS: 475231-21-1纯度: >99.00%
3'-Hydroxypterostilbene (3'-HPT) is one of the active constituents of Sphaerophysa salsula and Pterocarpus marsupium which may be useful in treating different types of haematological malignancies. 3'-Hydroxypterostilbene, a natural pterostilbene analogue, effectively inhibits the growth of human colon cancer cells (IC50s of 9.0, 40.2, and 70.9 ?M for COLO 205, HCT-116, and HT-29 cells, respectively) by inducing apoptosis and autophagy. 3'-Hydroxypterostilbene inhibits the PI3K/Akt/mTOR/p70S6K, and p38MAPK pathways and activates the ERK1/2, JNK1/2 MAPK pathways.
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC33833 | Tetrahydrocurcumin (HZIV 81-2) | 36062-04-1 | - | |
A metabolite of curcumin with diverse biological activities | ||||
| GC33848 | Fludrocortisone acetate (9α-Fludrocortisone acetate) | 514-36-3 | >99.50% | |
A mineralocorticoid agonist | ||||
| GC34009 | Nitroprusside disodium dihydrate (Sodium nitroprusside dihydrate) | 13755-38-9 | >99.50% / >99.00% | |
Sodium Nitroprusside Dihydrate is a potent vasodilator working through releasing NO spontaneously in blood. | ||||
| GC34010 | Danshensu (Dan shen suan A) | 76822-21-4 | >98.00% | |
丹参素是丹参的一种活性成分，通过激活 Nrf2 信号通路显示出广泛的心血管益处。 | ||||
| GC34014 | Trimetazidine dihydrochloride | 13171-25-0 | >99.50% | |
Trimetazidine dihydrochloride是一种亲脂性piperazine衍生物，用于治疗心绞痛。 | ||||
| GC34035 | Meglutol (Dicrotalic acid) | 503-49-1 | >98.00% | |
An HMG-CoA reductase inhibitor | ||||
| GC34057 | TBHQ (tert-Butylhydroquinone) | 1948-33-0 | >99.50% | |
TBHQ(tert-Butylhydroquinone)是一种强效的酚类抗氧化剂，能够减轻氧化应激和炎症反应。 | ||||
| GC34072 | Talmapimod (SCIO-469) | 309913-83-5 | >98.00% | |
A p38 MAPK inhibitor | ||||
| GC34094 | Mycro 3 | 944547-46-0 | >99.00% | |
Mycro 3 is a potent and selective inhibitor of c-Myc in whole cell assays. Mycro 3 also shows weak inhibitory activity against AP-1. | ||||
| GC34096 | (R)-(-)-Gossypol acetic acid (AT-101 (acetic acid)) | 866541-93-7 | >98.00% | |
(R)-(-)-Gossypol acetic acid (AT-101 (acetic acid))是一种新型的、具有口服活性的Bcl-2家族蛋白抑制剂，可抑制Bcl-2（K i =260±30nM），Mcl-1（K i =170±10nM）和Bcl-xL（K i =480±40nM）。 | ||||
| GC34117 | SMER18 | 944153-47-3 | - | |
SMER18是Rapamycin的一种小分子增强剂,充当mTOR非依赖性的的自噬诱导剂。 | ||||
| GC34173 | LG-100064 | 153559-46-7 | >99.50% | |
LG-100064是一种类视黄醇X受体(retinoid-X-receptor(RXR))激动剂，对RXRα，RXRβ和RXRγ的EC50值分别为330nM，200nM和260nM；LG-100064可用于癌症研究。 | ||||
| GC34330 | XRK3F2 | 2375193-43-2 | >95.00% / >98.50% | |
XRK3F2 is an inhibitor of the p62-ZZ domain that blunts MM-induced Runx2 suppression in vitro, and induces new bone formation and remodeling in the presence of tumor in vivo. | ||||
| GC34390 | Autocamtide 2, amide | - | >99.00% | |
Autocamtide2,amide是钙调蛋白激酶(CaMK)家族实验的底物(100μMfinalconcentration)。 | ||||
| GC34532 | CFTR corrector 2 | 1628416-28-3 | >99.50% | |
FDL169 is a CFTR corrector that is designed to fix and restore the function of the defective CFTR protein. | ||||
| GC34686 | Nidufexor | 1773489-72-7 | >98.50% | |
An FXR partial agonist | ||||
| GC34745 | PTI-428 | 1953130-87-4 | >99.50% | |
PTI-428是一种可增强并稳定囊性纤维化跨膜传导调节因子（CFTR）蛋白功能的特异性调节剂。 | ||||
| GC34849 | UBCS039 | 358721-70-7 | >98.50% | |
UBCS039 is the first synthetic SIRT6 activator with EC50 of 38 μM,induces a time-dependent activation of autophagy in several human tumor cell lines. | ||||
| GC34862 | WYC-209 | 2131803-90-0 | >99.50% | |
WYC-209是一种合成类视黄醇，能抑制恶性小鼠黑色素瘤肿瘤再生细胞(TRC)的增殖，IC50值为0.19μM。WYC-209主要细胞靶点是维甲酸受体(RARs)。 | ||||
| GC34918 | MW-150 dihydrochloride dihydrate | 1661020-92-3 | - | |
An inhibitor of p38α MAPK | ||||
| GC34924 | NSC 185058 | 39122-38-8 | >98.00% | |
NSC 185058是一种ATG4B的合成抑制剂，IC 50 值为51μM。 | ||||
| GC34960 | (+)-Talarozole | 201410-66-4 | >99.50% | |
(+)-Talarozole 是视黄酸代谢的有效抑制剂，来自专利 WO 1997049704 A1。 | ||||
| GC35068 | 1-Monomyristin | 589-68-4 | >98.00% | |
A monoacylglycerol | ||||
| GC35112 | 3'-Hydroxypterostilbene | 475231-21-1 | >99.00% | |
3'-Hydroxypterostilbene (3'-HPT) is one of the active constituents of Sphaerophysa salsula and Pterocarpus marsupium which may be useful in treating different types of haematological malignancies. 3'-Hydroxypterostilbene, a natural pterostilbene analogue, effectively inhibits the growth of human colon cancer cells (IC50s of 9.0, 40.2, and 70.9 ?M for COLO 205, HCT-116, and HT-29 cells, respectively) by inducing apoptosis and autophagy. 3'-Hydroxypterostilbene inhibits the PI3K/Akt/mTOR/p70S6K, and p38MAPK pathways and activates the ERK1/2, JNK1/2 MAPK pathways. | ||||