TBHQ(tert-Butylhydroquinone) is a powerful phenolic antioxidant capable of reducing oxidative stress and inflammatory reactions. It triggers the activation of Nrf2 and is recognized for its anti-inflammatory, anti-apoptotic, and neuroprotective properties[1-3].
TBHQ(tert-Butylhydroquinone) treatment(Pre-treating with 40μM) for 16 hours reduced paraquat (PQ)-induced apoptosis in cells [4]. TBHQ(tert-Butylhydroquinone) inhibits apoptosis and mitigates oxidative stress by activating the Nrf2/HO-1 pathway in HepG2 cells[5].
TBHQ(tert-Butylhydroquinone) (16.7mg/kg/d;daily for 5 days ;i.p) markedly ameliorated depression-like behavior induced by LPS and suppressed inflammatory responses along with microglial activation in mice [6]. TBHQ(tert-Butylhydroquinone) (50 mg/kg body weight in 1% DMSO; p.o; 14days) shields the testicular tissue and maintains steroidogenesis and spermatogenesis in rats treated with DOX by suppressing oxidative stress, inflammation, and apoptosis [7].
References:
[1]. Lu XY, Wang HD, et,al. Pretreatment with tert-butylhydroquinone attenuates cerebral oxidative stress in mice after traumatic brain injury. J Surg Res. 2014 May 1;188(1):206-12. doi: 10.1016/j.jss.2013.11.1106. Epub 2013 Dec 1. PMID: 24387843.
[2]. Bai J, Yu XJ, et,al. Tert-butylhydroquinone attenuates oxidative stress and inflammation in hypothalamic paraventricular nucleus in high salt-induced hypertension. Toxicol Lett. 2017 Nov 5;281:1-9. doi: 10.1016/j.toxlet.2017.08.018. Epub 2017 Aug 24. PMID: 28844481.
[3]. Sukumari-Ramesh S, Alleyne CH Jr. Post-Injury Administration of Tert-butylhydroquinone Attenuates Acute Neurological Injury After Intracerebral Hemorrhage in Mice. J Mol Neurosci. 2016 Apr;58(4):525-31. doi: 10.1007/s12031-016-0722-y. Epub 2016 Feb 11. PMID: 26867538.
[4]. Li H, Wu S, et,al. Neuroprotective effects of tert-butylhydroquinone on paraquat-induced dopaminergic cell degeneration in C57BL/6 mice and in PC12 cells. Arch Toxicol. 2012 Nov;86(11):1729-40. doi: 10.1007/s00204-012-0935-y. Epub 2012 Sep 15. PMID: 22983789.
[5]. Li R, Zhang P, et,al. Tert-butylhydroquinone mitigates Carbon Tetrachloride induced Hepatic Injury in mice. Int J Med Sci. 2020 Jul 29;17(14):2095-2103. doi: 10.7150/ijms.45842. PMID: 32922170; PMCID: PMC7484658.
[6]. Bian H, Yan F, et,al.Tert-butylhydroquinone prevents neuroinflammation and relieves depression via regulation of NLRP3 signaling in mice. Int Immunopharmacol. 2022 Jun;107:108723. doi: 10.1016/j.intimp.2022.108723. Epub 2022 Mar 23. PMID: 35338961.
[7]. Ujah GA, Nna VU, et,al. Tert-butylhydroquinone attenuates doxorubicin-induced dysregulation of testicular cytoprotective and steroidogenic genes, and improves spermatogenesis in rats. Sci Rep. 2021 Mar 9;11(1):5522. doi: 10.1038/s41598-021-85026-7. PMID: 33750916; PMCID: PMC7970903.
TBHQ(tert-Butylhydroquinone)是一种强效的酚类抗氧化剂，能够减轻氧化应激和炎症反应。它能激活Nrf2并有抗炎、抗凋亡和神经保护作用[1-3]。
40μM TBHQ(tert-Butylhydroquinone)预处理细胞16小时可减少百草枯(PQ)诱导的细胞凋亡[4]。TBHQ(tert-Butylhydroquinone)通过激活HepG2细胞Nrf2/HO-1通路抑制细胞凋亡，降低氧化应激[5]。
TBHQ(tert-Butylhydroquinone) (16.7mg/kg/d;daily for 5 days ;i.p)可显著改善LPS诱导的小鼠抑郁样行为，抑制炎症反应及小胶质细胞激活[6]。在DOX处理的大鼠中，TBHQ(tert-Butylhydroquinone) (50 mg/kg in 1% DMSO; p.o; 14days)通过抑制氧化应激、炎症和细胞凋亡来保护睾丸组织并维持类固醇生成和精子发生[7]。