Fludrocortisone acetate is the acetate form of the synthetic corticosteroid fludrocortisone, which is a mineralocorticoid receptor agonist.1 Fludrocortisone acetate (0.1-5 ?g/animal) promotes sodium retention in rats in a dose-dependent manner with 37% of sodium excreted compared with control when used at a dose of 5 ?g/animal.2 Formulations containing fludrocortisone acetate have been used in the treatment of Addison’s disease.
1.Agarwal, M.K., Coupry, F., and Philippe, M.Physiological activity and receptor binding of 9α fluorohydrocortisoneBiochem. Biophys. Res. Commun.78(2)747-753(1977) 2.Stafford, R.O., Barnes, L.E., Bowman, B.J., et al.Glucocorticoid and mineralocorticoids activities of Delta1-fluorohydrocortisoneProc. Soc. Exp. Biol. Med.89(3)371-374(1955)