Autophagy(自噬)

Autophagy is a catabolic process which degrades and recycles long-lived proteins and cytoplasmic organelles through lysosome. It plays an important role in growth regulation and maintenance of homeostasis.

Products for Autophagy

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Cat.No. 产品名称 Information
GC10330 Lonafarnib

洛那法尼,Sch 66336, Sch66336, Sch-66336
A farnesyltransferase inhibitor with antitumor activity
GC61003 Loperamide D6 hydrochloride

4-[4-(4-氯苯基)-4-羟基哌啶-1-基]-2,2-二苯基-N,N-二(三氘甲基)丁酰胺盐酸盐,R-18553-d6 hydrochloride
LoperamideD6hydrochloride(R-18553D6hydrochloride)是Loperamidehydrochloride的氘代化合物。Loperamidehydrochloride是一种阿片受体(opioidreceptor)的激动剂，可用于腹泻的研究。
GC36479 Loperamide hydrochloride

盐酸洛哌丁胺; R-18553 hydrochloride
An Analytical Reference Standard
GC13717 Losmapimod

洛批莫德; GSK-AHAB; GW856553X; SB856553
A dual p38α and p38β MAPK inhibitor
GC11633 Lovastatin

洛伐他汀; Mevinolin

Lovastatin是一种3-羟基-3-甲基戊二酰辅酶A（HMG-CoA）还原酶抑制剂，通过影响甲羟戊酸途径来发挥作用，IC₅₀值为77nM。
GC33126 Lucanthone

硫蒽酮
Lucanthone is a novel autophagic inhibitor and also an orally available thioxanthone-based DNA intercalator and inhibitor of the DNA repair enzyme apurinic-apyrimidinic endonuclease 1.
GC32152 Lumefantrine (Benflumetol)

苯芴醇; Benflumetol
An antimalarial drug
GC64363 Lumefantrine-d9

Benflumetol-d9
Lumefantrine-d9 (Benflumetol-d9) 是 Lumefantrine 的氘代物。Lumefantrine是一种抗疟疾药物, 与Artemether联用, 作为一线和二线抗疟药。
GN10370 Luteolin

木犀草素; Luteoline; Luteolol; Digitoflavone
木犀草素（Luteolin）是一种黄酮类化合物，具有抗炎、抗氧化、抗癌等多种功能。Luteolin是一种有效的核因子红细胞2相关因子2（Nrf2）抑制剂。
GC65432 LV-320 LV-320 是一种有效且非竞争性的 ATG4B 抑制剂，其 IC50 值为 24.5 μM，Kd 值为 16 μM。 LV-320 抑制 ATG4B 的酶促活性，阻断细胞自噬，并且在体内稳定，无毒且有活性。
GC30884 LX2343 An inhibitor of BACE1 and PI3K
GC15485 LY 294002

LY294002/PI3K抑制剂

LY294002是第一个合成的PI3Kα、δ和β抑制剂。
GC50009 LY 294002 hydrochloride Prototypical PI 3-kinase inhibitor; also inhibits other kinases
GC12363 LY2109761 LY2109761是一种口服小分子双TGF-β受体（TβR）I/II激酶抑制剂（TβRI: K_i = 38nM；TβRII: K_i = 300nM）。
GC15094 LY2183240

5-([1,1'-联苯]-4-甲基)-N,N-二甲基-1H-四氮唑-1-甲酰胺,LY 2183240; LY-2183240
A potent, competitive inhibitor of anandamide uptake
GC16835 LY2228820

5-[2-(叔丁基)-4-(4-氟苯基)-1H-咪唑-5-基]-3-(2,2-二甲基丙基)-3H-咪唑并[4,5-B]吡啶-2-胺甲磺酸盐,LY2228820 dimesylate
A potent inhibitor of p38α MAP kinase
GC19421 LY2562175 An FXR agonist
GC15741 LY2603618

LY2603618; IC-83
A Chk1 inhibitor
GC19232 LY2955303 A potent RARγ antagonist
GC13980 LY3009120

DP-4978
LY3009120 是一种泛 RAF 和 RAF 二聚体抑制剂，可抑制所有 RAF 亚型并占据 RAF 二聚体中的两个原聚体。
GC14371 LY3023414

LY3023414
LY3023414 (LY3023414) potently and selectively inhibits class I PI3K isoforms, DNA-PK, and mTORC1/2 with IC50s of 6.07 nM, 77.6 nM, 38 nM, 23.8 nM, 4.24 nM and 165 nM for PI3Kα, PI3Kβ, PI3Kδ , PI3Kγ, DNA-PK 和 mTOR, 分别。 LY3023414 在低纳摩尔浓度下有效抑制 mTORC1/2。
GN10396 Lycorine chloride

石蒜碱
An alkaloid with diverse biological activities
GC19236 LYN-1604 A ULK1 activator
GC36517 LYN-1604 hydrochloride A ULK1 activator
GC19237 Lys01 trihydrochloride

Lys01 trihydrochloride
An inhibitor of autophagy
GN10301 Magnolol

厚朴酚
A CB₂ receptor agonist
GC40007 Malformin A

Malformin A1
A cyclopentapeptide fungal metabolite with diverse biological activities
GC30676 MAPK13-IN-1 MPAK13-IN-1是MAPK13(p38δ)的一个抑制剂，其IC50值为620nM。
GC12376 Maprotiline HCl

盐酸马普替林
A tricyclic antidepressant
GC71655 Maprotiline-d5 hydrochloride Maprotiline-d5 hydrochloride是氘标记的盐酸马普替林。
GC17874 Matrine

苦参碱; Matridin-15-one; Vegard; α-Matrine
苦参碱（Matrine）是一种存在于槐属植物中的生物碱，可作为 kappa 阿片受体和µ-受体激动剂。
GC10200 Mdivi 1

3-(2,4-二氯-5-甲氧基苯基)-2,3-二氢-2-硫代-4(1H)-喹唑啉酮,Mitochondrial division inhibitor 1
Mdivi-1（线粒体分裂抑制剂 1）抑制创伤性脑损伤 (TBI) 诱导的动力蛋白相关蛋白 1 (Drp1) 上调、自噬功能障碍和线粒体自噬激活。
GC12385 MDV3100 (Enzalutamide)

恩杂鲁胺; MDV3100
MDV3100(enzalutamide) 是第二代 AR 拮抗剂，在 LNCaP 前列腺细胞中的 IC50 为 36nM。
GC13252 Meclizine 2HCl

盐酸美克洛嗪; Meclozine dihydrochloride
A histamine H₁ receptor antagonist
GC15854 Mefloquine hydrochloride

盐酸甲氟喹,Mefloquin hydrochloride
An antimalarial compound
GC11688 Megestrol Acetate

醋酸甲地孕酮
A synthetic progestogen
GC34035 Meglutol (Dicrotalic acid)

3-羟基-3-甲基谷氨酸,Dicrotalic acid; 3-Hydroxy-3-methylglutaric acid
An HMG-CoA reductase inhibitor
GC12843 MEK162 (ARRY-162, ARRY-438162)

贝美替尼,MEK162; ARRY-162; ARRY-438162
A MEK1/2 inhibitor
GC15618 Melatonin

褪黑素; N-Acetyl-5-methoxytryptamine

An indoleamine neurohormone that entrains circadian rhythms
GC60241 Melatonin D5

褪黑素 D5; N-Acetyl-5-methoxytryptamine-d4
An internal standard for the quantification of melatonin
GC11762 Meloxicam (Mobic)

美洛昔康
A selective COX-2 inhibitor
GC40065 Meloxicam-d3

美洛昔康 d3
An internal standard for the quantification of meloxicam
GC10198 Memantine hydrochloride

盐酸美金刚; D-145 hydrochloride
An NMDA receptor antagonist
GC15668 Meprednisone

泼尼松
A corticosteroid
GC13704 Mercaptopurine (6-MP)

6-巯基嘌呤; Mercaptopurine; 6-MP
巯基嘌呤（6-MP）是一种嘌呤类似物，可作为内源性嘌呤的拮抗剂，被广泛用作抗白血病药和免疫抑制剂。
GC60245 Metformin

二甲双胍; 1,1-Dimethylbiguanide
二甲双胍（1,1-二甲基双胍）主要介导 AMPK 的激活，AMPK 是一种参与调节细胞能量代谢的丝氨酸/苏氨酸蛋白激酶，可导致癌细胞中 mTOR 信号传导和蛋白质合成的减少。
GC61045 Metformin D6 hydrochloride

二甲双胍盐酸,1,1-Dimethylbiguanide-d6 hydrochloride
An internal standard for the quantification of metformin
GC17443 Metformin HCl

盐酸二甲双胍; 1,1-Dimethylbiguanide hydrochloride

A biguanide with diverse biological activities
GC15505 Methylprednisolone

甲泼尼龙; U 7532
甲泼尼龙是皮质类固醇,可作用于糖皮质激素受体并抑制皮质醇分泌,其IC50为1.7ng/ml。
GC30356 Metofenazate (Methophenazine)

美托奋乃酯,Methophenazine
Metofenazate (Methophenazine) 是一种选择性钙调蛋白抑制剂。