EGFR
EGFR(表皮生长因子受体)
EGFR (epidermal growth factor receptor) is the cell-surface receptor of its specific ligands, including epidermal growth factor and TGFα (transforming growth factor α) and is a receptor tyrosine kinase.
EGFR 相关产品(264)
- GC38350Epertinib hydrochlorideCAS: 2071195-74-7纯度: >99.50%
Epertinib hydrochloride (S-222611 hydrochloride) is a potent, orally active, reversible, and selective tyrosine kinase inhibitor of EGFR, HER2 and HER4 with IC50 of 1.48 nM, 7.15 nM and 2.49 nM, respectively. Epertinib hydrochloride (S-222611 hydrochloride) exhibits antitumor activity.
- GC40222Lapatinib-d4 (tosylate)CAS: 2749856-05-9纯度: >99.00%
An internal standard for the quantification of lapatinib
- GC44085L-SulforapheneCAS: 592-95-0纯度: >99.00% / >98.00% / >95.00%
L-Sulforaphene是一种天然的异硫氰酸酯，具有抗炎、抗癌和抗氧化作用。
- GC47303Erlotinib-d6 (hydrochloride)CAS: 1189953-78-3纯度: >99.00%
An internal standard for the quantification of erlotinib
- GC50706JBJ-03-142-02CAS: 2068806-31-3纯度: >98.00%
Highly potent epidermal growth factor receptor (EGFR) and ErbB2 (human epidermal growth factor receptor; HER2) inhibitor
- GC60567Afatinib impurity 11CAS: 1402086-20-7纯度: >99.00%
Afatinib impurity 11 is an impurity of afatinib, an EGFR family inhibitor.
- GC60868Gefitinib D8CAS: 857091-32-8纯度: >98.00%
GefitinibD8(ZD1839D8)是Gefitinib的氘代物。Gefitinib是一种有效的(EGFR)抑制剂，在NR6wtEGFR细胞中IC50值为2-37nM。
- GC61161Osimertinib D6纯度: >99.50%
OsimertinibD6(AZD-9291D6)是Osimertinib的一种氘代化合物。Osimertinib是一种不可逆和突变的选择性的EGFR抑制剂，抑制EGFRL858R和EGFRL858R/T790M的IC50分别为12和1nM。
- GC61473Trastuzumab deruxtecanCAS: 1826843-81-5纯度: >98.50% / >99.00%
Trastuzumab deruxtecan（曲妥珠单抗）是一种人表皮生长因子受体2（HER2）靶向抗体-药物偶联物（ADC），由人源化抗人HER2（抗hHER2）抗体、酶促裂解肽接头和拓扑异构酶I抑制剂（DX-8951衍生物）组成。
- GC61490Trastuzumab emtansineCAS: 1018448-65-1纯度: >98.00%
Trastuzumab Emtansine(T-DM1,Ado-Trastuzumab emtansine) is an antibody-drug conjugate (ADC) that incorporates the HER2-targeted antitumor properties of trastuzumab with the cytotoxic activity of the microtubule-inhibitory agent DM1.Trastuzumab emtansine has a molecular weight of 145kDa.
- GC61807(E/Z)-AG490CAS: 134036-52-5纯度: >98.00%
(E/Z)-AG490((E/Z)-TyrphostinAG490)是(E)-AG490和(Z)-AG490的消旋体。(E)-AG490是一种酪氨酸激酶抑制剂，可抑制EGFR，Stat-3和JAK2/3。
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC38350 | Epertinib hydrochloride | 2071195-74-7 | >99.50% | |
Epertinib hydrochloride (S-222611 hydrochloride) is a potent, orally active, reversible, and selective tyrosine kinase inhibitor of EGFR, HER2 and HER4 with IC50 of 1.48 nM, 7.15 nM and 2.49 nM, respectively. Epertinib hydrochloride (S-222611 hydrochloride) exhibits antitumor activity. | ||||
| GC38402 | BI-4020 | 2664214-60-0 | >99.00% | |
BI-4020 is an orally active, non-covalent EGFR inhibitor with IC50 of 0.6 nM and 0.2 nM for EGFRdel19 T790M C797S as biomarker potency and anti-proliferation potency in BaF3 cells, respectively. | ||||
| GC40222 | Lapatinib-d4 (tosylate) | 2749856-05-9 | >99.00% | |
An internal standard for the quantification of lapatinib | ||||
| GC40915 | PKI-166 | 187724-61-4 | >98.50% | |
An inhibitor of EGFR | ||||
| GC41577 | Tephrosin (synthetic) | 76-80-2 | >98.00% | |
An antineoplastic and piscicidal rotenoid | ||||
| GC44085 | L-Sulforaphene | 592-95-0 | >99.00% / >98.00% / >95.00% | |
L-Sulforaphene是一种天然的异硫氰酸酯，具有抗炎、抗癌和抗氧化作用。 | ||||
| GC44263 | Myrtillin | 6906-38-3 | >99.50% / >98.00% | |
桃金娘苷（Delphinidin 3-o-glucoside）是一种花青素单体，主要分布于各种植物中，可用高效液相色谱法（HPLC）质谱法（Mass）和核磁共振法进行定性和定量分析(NMR)。 | ||||
| GC44491 | O-Desmethyl Gefitinib | 847949-49-9 | >98.00% | |
A major active metabolite of gefitinib | ||||
| GC44583 | PD 089828 | 179343-17-0 | >98.00% | |
An inhibitor of EGFR, PDGFβ, FGF, and c-Src | ||||
| GC47303 | Erlotinib-d6 (hydrochloride) | 1189953-78-3 | >99.00% | |
An internal standard for the quantification of erlotinib | ||||
| GC49617 | PD 153035 | 153436-54-5 | >98.00% | |
A potent EGFR kinase inhibitor | ||||
| GC50013 | AG 1478 hydrochloride | 170449-18-0 | - | |
An inhibitor of EGF receptor kinase | ||||
| GC50026 | BIBX 1382 dihydrochloride | 1216920-18-1 | - | |
An EGFR inhibitor | ||||
| GC50083 | PKI 166 hydrochloride | 2230253-82-2 | - | |
An inhibitor of EGFR | ||||
| GC50706 | JBJ-03-142-02 | 2068806-31-3 | >98.00% | |
Highly potent epidermal growth factor receptor (EGFR) and ErbB2 (human epidermal growth factor receptor; HER2) inhibitor | ||||
| GC60154 | Erlotinib D6 | 1034651-23-4 | - | |
An internal standard for the quantification of erlotinib | ||||
| GC60567 | Afatinib impurity 11 | 1402086-20-7 | >99.00% | |
Afatinib impurity 11 is an impurity of afatinib, an EGFR family inhibitor. | ||||
| GC60868 | Gefitinib D8 | 857091-32-8 | >98.00% | |
GefitinibD8(ZD1839D8)是Gefitinib的氘代物。Gefitinib是一种有效的(EGFR)抑制剂，在NR6wtEGFR细胞中IC50值为2-37nM。 | ||||
| GC61161 | Osimertinib D6 | - | >99.50% | |
OsimertinibD6(AZD-9291D6)是Osimertinib的一种氘代化合物。Osimertinib是一种不可逆和突变的选择性的EGFR抑制剂，抑制EGFRL858R和EGFRL858R/T790M的IC50分别为12和1nM。 | ||||
| GC61473 | Trastuzumab deruxtecan | 1826843-81-5 | >98.50% / >99.00% | |
Trastuzumab deruxtecan（曲妥珠单抗）是一种人表皮生长因子受体2（HER2）靶向抗体-药物偶联物（ADC），由人源化抗人HER2（抗hHER2）抗体、酶促裂解肽接头和拓扑异构酶I抑制剂（DX-8951衍生物）组成。 | ||||
| GC61490 | Trastuzumab emtansine | 1018448-65-1 | >98.00% | |
Trastuzumab Emtansine(T-DM1,Ado-Trastuzumab emtansine) is an antibody-drug conjugate (ADC) that incorporates the HER2-targeted antitumor properties of trastuzumab with the cytotoxic activity of the microtubule-inhibitory agent DM1.Trastuzumab emtansine has a molecular weight of 145kDa. | ||||
| GC61780 | SU5204 | 186611-11-0 | >98.50% | |
SU5204 is a tyrosine kinase inhibitor with IC50 of 4 μM and 51.5 μM for FLK-1 (VEGFR-2) and HER2, respectively. | ||||
| GC61807 | (E/Z)-AG490 | 134036-52-5 | >98.00% | |
(E/Z)-AG490((E/Z)-TyrphostinAG490)是(E)-AG490和(Z)-AG490的消旋体。(E)-AG490是一种酪氨酸激酶抑制剂，可抑制EGFR，Stat-3和JAK2/3。 | ||||
| GC62159 | Tucatinib hemiethanolate | 1429755-56-5 | >99.00% | |
An inhibitor of HER2 | ||||