GlpBio

PI3K

PI3K (phosphatidylinositol-4,5-bisphosphate 3-kinase) is a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer.

PI3K 相关产品(222)

  • GC19283 structure
    GC19283PF-04979064
    CAS: 1220699-06-8
    纯度: >99.50%

    PF-04979064 是一种有效的选择性 PI3K/mTOR 双激酶抑制剂，对 PI3Kα 和 mTOR 的 Kis 分别为 0.13 nM 和 1.42 nM。

  • GC19300 structure
    GC19300PQR309
    CAS: 1225037-39-7
    纯度: >98.50%

    PQR309 是一种有效的脑渗透性口服生物利用度泛 I 类 PI3K/mTOR 抑制剂，对 PI3Kα、PI3Kδ、PI3Kβ、PI3Kγ 和 mTOR 的 IC50 分别为 33nM、451nM、661nM、708nM 和 89nM .PQR309 在人脑胶质瘤细胞中通过抑制增殖、诱导细胞凋亡、诱导 G1 细胞周期停滞、抑制侵袭和迁移等方式发挥抗肿瘤作用。

  • GC19328 structure
    GC19328SF2523
    CAS: 1174428-47-7

    A dual inhibitor of PI3K and BRD4

  • GC19355 structure
    GC19355Umbralisib
    CAS: 1532533-67-7
    纯度: >98.50%

    A PI3K p110δ inhibitor

  • GC19411 structure
    GC19411IITZ-01
    CAS: 1807988-47-1
    纯度: >99.00%

    IITZ-01 是一种有效的溶酶体自噬抑制剂，具有单剂抗肿瘤活性，对 PI3Kγ 的 IC50 为 2.62 μM。

  • GC19471 structure
    GC19471Leniolisib
    CAS: 1354690-24-6
    纯度: >99.00%

    An inhibitor of PI3Kδ

  • GC19540 structure
    GC19540α-Linolenic Acid
    CAS: 463-40-1
    纯度: >98.00% / >99.00% / >99.50%

    An essential ω-3 polyunsaturated fatty acid

  • GC19921 structure
    GC19921Phenylarsine Oxide
    CAS: 637-03-6
    纯度: >98.00%

    An organoarsenic compound

  • GC25913 structure
    GC25913Selective PI3Kδ Inhibitor 1 (compound 7n)
    CAS: 2088525-31-7

    Selective PI3Kδ Inhibitor 1 (compound 7n) is an inhibitor of PI3Kδ with an IC50 of 0.9 nM and >1000-fold selectivity against other class I PI3K isoforms [PI3K α/γ/β=3670/1460/21300 nM].

  • GC26044 structure
    GC26044VPS34 inhibitor 1 (Compound 19)
    CAS: 1383716-46-8

    VPS34 inhibitor 1 (Compound 19, PIK-III analogue) is a potent and selective inhibitor of VPS34 with an IC50 of 15 nM.

  • GC30156 structure
    GC30156Brevianamide F (Cyclo(L-Pro-L-Trp))
    CAS: 38136-70-8
    纯度: >99.00%

    An alkaloid with diverse biological activities

  • GC30884 structure
    GC30884LX2343
    CAS: 333745-53-2
    纯度: >99.50%

    An inhibitor of BACE1 and PI3K

  • GC31666 structure
    GC31666Seletalisib (UCB5857)
    CAS: 1362850-20-1
    纯度: >98.50%

    Seletalisib (UCB-5857) is a novel small-molecule inhibitor of PI3Kδ with an IC50 value of 12 nM and shows significant selectivity to PI3Kδ with respect to the other class I PI3K isoforms (between 24- and 303-fold).

  • GC31751 structure
    GC31751PI3Kδ-IN-2
    CAS: 1702816-75-8
    纯度: >99.50%

    PI3Kδ-IN-2 (YY-20394) 是 PI3Kδ 的强效、口服生物利用度和选择性抑制剂；提取自专利WO 2015055071 A1，化合物10； IC50 为 6.4 nM。

  • GC31756 structure
    GC31756IPI-3063
    CAS: 1425043-73-7
    纯度: >98.50%

    IPI-3063 is a potent and selective p110δ inhibitor with biochemical IC50 of 2.5?±?1.2 nM and IC50 values for the other class I PI3K isoforms (p110α, p110β, p110γ) are at least 400-fold higher.

  • GC32710 structure
    GC32710GDC-0077 (RG6114)
    CAS: 2060571-02-8
    纯度: >98.00% / >99.00%

    GDC-0077 (RG6114)是一种高效且选择性的PI3Kα抑制剂，IC 50 值为0.038nM。

  • GC32828 structure
    GC32828Tenalisib (RP6530)
    CAS: 1639417-53-0
    纯度: >98.50%

    Tenalisib (RP6530) is a potent and selective dual PI3Kδ/γ inhibitor with IC50 values of 24.5 nM and 33.2 nM for PI3Kδ and PI3Kγ, respectively. Its selectivity over α and β isoforms are more than 300-fold and 100-fold, respectively.

  • GC32847 structure
    GC32847PI4KIIIbeta-IN-9
    CAS: 1429624-84-9
    纯度: >99.00%

    PI4KIIIbeta-IN-9是一种有效的PI4KIIIβ抑制剂，IC50为7nM。PI4KIIIbeta-IN-9也抑制PI3Kδ和PI3Kγ，IC50分别为152nM和1046nM。

  • GC32916 structure
    GC32916Parsaclisib (INCB050465)
    CAS: 1426698-88-5
    纯度: >99.00%

    Parsaclisib (INCB050465, INCB-50465, IBI376) is a potent and highly selective PI3Kδ(PI3K delta) inhibitor with an IC50 of 1 nM at 1 mM ATP in biochemical assay and approximately 20,000-fold selectivity for PI3Kα, PI3Kβ, PI3Kγ and 57 other kinases.

  • GC32932 structure
    GC32932Vps34-IN-2
    CAS: 1523404-29-6
    纯度: >99.50%

    Vps34-IN-2是一种新型的，有效且有选择性的Vps34抑制剂，在Vps34酶促测定和GFP-FYVE细胞测定中的IC50值分别为2和82nM。

  • GC33014 structure
    GC33014NSC781406
    CAS: 1676893-24-5
    纯度: >99.50%

    A dual inhibitor of PI3K and mTOR

  • GC33130 structure
    GC33130Recilisib (Ex-RAD)
    CAS: 334969-03-8
    纯度: >98.00%

    Recilisib (Ex-RAD)是一种辐射防护剂，可以激活细胞中AKT和PI3K的活性。

  • GC33145 structure
    GC33145BEBT-908 (PI3Kα inhibitor 1)
    CAS: 1235449-52-1
    纯度: >99.00%

    BEBT-908 (PI3Kα inhibitor 1) (PI3Kα inhibitor 1) 是一种选择性 PI3Kα从专利US/20120088764A1中提取的抑制剂化合物243，IC50<0.1 μM, PI3Kα抑制剂 1 还抑制 HDAC (0.1 μM≤IC50≤1 μM)。

  • GC33162 structure
    GC33162Duvelisib R enantiomer (IPI-145 R enantiomer)
    CAS: 1261590-48-0

    Duvelisib R 对映异构体是一种 PI3K 抑制剂，是 Duvelisib 活性较低的对映异构体。