GlpBio

PI3K

PI3K (phosphatidylinositol-4,5-bisphosphate 3-kinase) is a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer.

PI3K 相关产品(222)

  • GC11177 structure
    GC11177GDC-0980 (RG7422)
    CAS: 1032754-93-0
    纯度: >98.00%

    A dual inhibitor of PI3K and mTOR

  • GC11248 structure
    GC11248AZD8835
    CAS: 1620576-64-8
    纯度: >98.50%

    An inhibitor of PI3Kα and PI3Kδ

  • GC11471 structure
    GC11471SAR405
    CAS: 1523406-39-4
    纯度: >99.00% / >98.00%

    SAR405是一种Vps34抑制剂(IC50=1.2 nM)，SAR405抑制mTOR抑制引起的自噬。

  • GC11910 structure
    GC11910AS-041164
    CAS: 6318-41-8
    纯度: >99.00%

    Selective inhibitor of PI3Kγ

  • GC11931 structure
    GC11931BKM120
    CAS: 944396-07-0
    纯度: >99.50%

    An inhibitor of class I PI3K isoforms

  • GC12338 structure
    GC12338Wortmannin
    CAS: 19545-26-7
    纯度: >99.50% / >98.00% / >99.00%

    渥曼青霉素是一种高效的 PI3 激酶特异性直接抑制剂，最初源自真菌 (1,2)。

  • GC12375 structure
    GC12375PF-4989216
    CAS: 1276553-09-3
    纯度: >99.50%

    An orally bioavailable PI3K inhibitor

  • GC12415 structure
    GC12415Rigosertib
    CAS: 592542-59-1
    纯度: >98.50%

    Rigosertib (ON-01910) 是一种多激酶抑制剂和选择性抗癌剂，通过抑制 PI3 激酶/Akt 通路诱导细胞凋亡，促进组蛋白 H2AX 的磷酸化并诱导细胞周期 G2/M 停滞。 Rigosertib 是一种选择性和非 ATP 竞争性的 PLK1 抑制剂，IC50 为 9 nM。

  • GC12416 structure
    GC12416INK1117
    CAS: 1268454-23-4
    纯度: >99.00%

    A selective inhibitor of PI3Kα

  • GC12474 structure
    GC12474AS-605240
    CAS: 648450-29-7
    纯度: >99.00%

    A potent inhibitor of PI3-kinase γ

  • GC12576 structure
    GC12576AZD8186
    CAS: 1627494-13-6
    纯度: >99.50%

    A PI3Kβ/δ inhibitor

  • GC12709 structure
    GC12709XL147
    CAS: 956958-53-5
    纯度: >99.50%

    An analog of XL147

  • GC12889 structure
    GC12889PX 866
    CAS: 502632-66-8
    纯度: >99.00%

    An inhibitor of PI3K

  • GC13271 structure
    GC13271BEZ235 Tosylate
    CAS: 1028385-32-1
    纯度: >98.00%

    BEZ235 Tosylate (BEZ235 Tosylate) 是一种双重 PI3K 和 mTOR 激酶抑制剂，对 PI3Kα, β, γ, δ 的 IC50 值分别为 4, 75, 7, 5 nM。 BEZ235 Tosylate (BEZ235 Tosylate) 抑制 mTORC1 和 mTORC2。

  • GC13321 structure
    GC13321WYE-687
    CAS: 1062161-90-3

    An mTOR inhibitor

  • GC13396 structure
    GC13396CAL-101 (Idelalisib, GS-1101)
    CAS: 870281-82-6
    纯度: >99.50%

    A selective PI3K p110δ inhibitor

  • GC13503 structure
    GC13503iMDK
    CAS: 881970-80-5
    纯度: >98.00%

    iMDK 是一种有效的 PI3K 抑制剂，可抑制生长因子 MDK（也称为中期因子或 MK）。 iMDK 与 MEK 抑制剂协同抑制非小细胞肺癌 (NSCLC)，而不会伤害正常细胞和小鼠。

  • GC13580 structure
    GC13580Rigosertib sodium
    CAS: 592542-60-4
    纯度: >98.50%

    Rigosertib sodium (ON-01910 sodium) 是一种多激酶抑制剂和选择性抗癌剂，通过抑制 PI3K/Akt 通路诱导细胞凋亡，促进组蛋白 H2AX 的磷酸化并诱导细胞周期 G2/M 停滞。 Rigosertib sodium 是一种选择性和非 ATP 竞争性的 PLK1 抑制剂，IC50 为 9 nM。

  • GC13725 structure
    GC13725NVP-BAG956
    CAS: 853910-02-8

    A dual PDK1 and class I PI3K inhibitor

  • GC13913 structure
    GC13913AMG319
    CAS: 1608125-21-8
    纯度: >98.00%

    Potent, selective PI3Kδ inhibitor

  • GC14346 structure
    GC14346KU-0060648
    CAS: 881375-00-4
    纯度: >99.00%

    A dual inhibitor of DNA-PK and PI3K

  • GC14371 structure
    GC14371LY3023414
    CAS: 1386874-06-1
    纯度: >98.00%

    LY3023414 (LY3023414) potently and selectively inhibits class I PI3K isoforms, DNA-PK, and mTORC1/2 with IC50s of 6.07 nM, 77.6 nM, 38 nM, 23.8 nM, 4.24 nM and 165 nM for PI3Kα, PI3Kβ, PI3Kδ , PI3Kγ, DNA-PK 和 mTOR, 分别。 LY3023414 在低纳摩尔浓度下有效抑制 mTORC1/2。

  • GC14504 structure
    GC14504NVP-BKM120 Hydrochloride
    CAS: 1312445-63-8
    纯度: >99.50%

    An inhibitor of class I PI3K isoforms

  • GC14679 structure
    GC14679PIK-III
    CAS: 1383716-40-2
    纯度: >99.50%

    A selective inhibitor of Vps34