GlpBio

Potassium Channel

Potassium Channel(钾离子通道)

Potassium channels are voltage-gated ion channels that selectively permeate potassium ion through the excitable membrane. It regulates the release of neurotransmitters, insulin secretion, smooth muscle contraction and heart rate etc.

Potassium Channel 相关产品(302)

  • GC10515 structure
    GC10515Tertiapin-Q
    CAS: 252198-49-5
    纯度: >99.50%

    A peptide derivative of tertiapin

  • GC10540 structure
    GC10540NS 11021
    CAS: 956014-19-0
    纯度: >99.00%

    NS 11021是一种具有高效选择性的大电导钙激活钾通道（BKCa/KCa1.1）激活剂。

  • GC10560 structure
    GC10560ICA 110381
    CAS: 325457-99-6

    ICA 110381 (Compound 16) 是一种 KCNQ2/Q3 钾通道开放剂，用于治疗癫痫。

  • GC10861 structure
    GC10861Domiphen Bromide
    CAS: 538-71-6
    纯度: >99.00%

    A quaternary ammonium compound and cationic surfactant with antimicrobial activity

  • GC10943 structure
    GC10943AM 92016 hydrochloride
    CAS: 133229-11-5
    纯度: >98.00%

    An I Kr inhibitor

  • GC10953 structure
    GC10953Tetraethylammonium chloride
    CAS: 56-34-8
    纯度: >98.00% / >97.00%

    Tetraethylammonium chloride是一种非特异性钾通道阻滞剂，其主要作用机制是通过结合通道孔内部位点抑制钾离子外流。

  • GC10978 structure
    GC10978Terfenadine
    CAS: 50679-08-8
    纯度: >98.00%

    A selective histamine H 1 -receptor antagonist

  • GC11061 structure
    GC11061ML 213
    CAS: 489402-47-3
    纯度: >99.50%

    A selective activator of KCNQ2 and KCNQ4 channels

  • GC11082 structure
    GC11082Paxilline
    CAS: 57186-25-1
    纯度: >98.00%

    Paxilline是一种致震颤真菌生物碱,可有效抑制高电导Ca2+ 激活K+ (BK)通道,IC50约为10nM,Ki=1.9nM。

  • GC11132 structure
    GC11132Y-26763
    CAS: 127408-31-5
    纯度: >99.00%

    An activator of K ATP channels

  • GC11315 structure
    GC11315ADWX 1

    Kv1.3 channel blocker,potent and selective

  • GC11351 structure
    GC11351VU590 (hydrochloride)

    inhibitor of KCNJ1

  • GC11421 structure
    GC11421L-364,373
    CAS: 103342-82-1
    纯度: >99.50%

    L-364,373 (R-L3) 是一种电压门控 Kv7.1 (KCNQ1)/水貂通道激活剂。

  • GC11429 structure
    GC11429DMP 543
    CAS: 160588-45-4
    纯度: >99.50%

    An inhibitor of K v 7.2

  • GC11470 structure
    GC11470Flupirtine maleate
    CAS: 75507-68-5
    纯度: >99.50%

    An activator of Kv7 channels

  • GC11550 structure
    GC11550JNJ 303
    CAS: 878489-28-2
    纯度: >99.00%

    An inhibitor of K v 7.1

  • GC11598 structure
    GC11598Diazoxide
    CAS: 364-98-7
    纯度: >99.50%

    An activator of SUR1/K ir 6.2

  • GC11608 structure
    GC11608Penitrem A
    CAS: 12627-35-9
    纯度: >95.00%

    An inhibitor of K Ca 1.1/BK channels

  • GC11919 structure
    GC11919XE 991 dihydrochloride
    CAS: 122955-13-9
    纯度: >98.00%

    XE 991 dihydrochloride是一种状态依赖性、选择性的KCNQ通道抑制剂，可抑制M电流、KCNQ2+KCNQ3、KCNQ2及KCNQ1（KvLQT1）， IC 50 分别为0.98±0.15μM、0.6±0.01μM、0.71±0.07μM和0.75±0.05μM。

  • GC12045 structure
    GC12045LY 303511
    CAS: 154447-38-8

    An inhibitor of cell proliferation

  • GC12090 structure
    GC12090Nonactin
    CAS: 6833-84-7
    纯度: >95.00%

    Nonactin是一种大环四内酯类抗生素和线粒体氧化磷酸化解偶联剂。

  • GC12140 structure
    GC12140Endoxifen
    CAS: 112093-28-4

    Endoxifen Z-异构体是最重要的他莫昔芬代谢物，负责在表达雌激素受体-α (ERα) 的乳腺癌细胞中引发该药物的抗雌激素作用。

  • GC12356 structure
    GC12356Glibenclamide
    CAS: 10238-21-8
    纯度: >99.50%

    格列本脲 (Glyburide) 是一种具有口服活性的 ATP 敏感性 K+ 通道 (KATP) 抑制剂，可用于糖尿病和肥胖症的研究。

  • GC12424 structure
    GC12424NS 1643
    CAS: 448895-37-2

    An activator of ERG1 and ERG2