GlpBio

NS 1643

目录号: GC12424纯度: >98%
COASDSData Sheet
An activator of ERG1 and ERG2
NS 1643
Cas No.: 448895-37-2
规格价格库存数量操作
5mg¥302.00现货
1
10mg¥494.00现货
1
25mg¥1,039.00现货
1
50mg¥1,724.00现货
1
100mg¥2,862.00现货
1
10mM (in 1mL DMSO)¥332.00现货
1
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文献被引

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产品描述 Description

NS1643 is a partial agonist of human ether-a-go-go-related gene (hERG) K(+) channels with an EC50 of 10.5 μM. NS1643 has distinct effects on erg2 (Kv11.2) currents by reducing channel inactivation especially at high concentrations[1]. NS1643 increases the repolarization reserve and exhibits an interesting new antiarrhythmic approach[2].

References:
[1]. Sun XJ, et al. The Role of Histone Acetyltransferases in Normal and Malignant Hematopoiesis. Front Oncol. 2015 May 26;5:108.
[2]. Casis O, et al. Mechanism of action of a novel human ether-a-go-go-related gene channel activator. Mol Pharmacol. 2006 Feb;69(2):658-65. Epub 2005 Nov 11.

产品文档 Product Documents

Purity:>98%
COASDSData Sheet

化学性质Chemical Properties

CAS 号
448895-37-2
化学名
1,3-bis(2-hydroxy-5-(trifluoromethyl)phenyl)urea
SMILES
FC(F)(C(C=C1)=CC(NC(NC(C=C(C(F)(F)F)C=C2)=C2O)=O)=C1O)F
分子式
C15H10F6N2O3
分子量
380.24 g/mol
溶解性
≥ 13.05mg/mL in DMSO
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol