GlpBio

STING

STING (Stimulator of Interferon Genes) is a transmembrane protein localized to the endoplasmic reticulum that undergoes a conformational change in response to direct binding of cyclic dinucleotides (CDNs), resulting in a downstream signaling cascade involving TBK1 activation, IRF-3 phosphorylation, and production of IFN-β and other cytokines.

STING is a pattern recognition receptor of cyclic dinucleotides as well as an innate immune adaptor protein that enables signaling from cytoplasmic receptors to the transcription factor interferon regulatory factor 3. Initiation of these pathways leads to the expression of type I interferons and proteins associated with antiviral and antitumor immunity. Small molecules capable of triggering STING-dependent cellular processes are effective at blocking virus replication, enhancing vaccine efficacy, and facilitating immune response to cancer cells.

STING 相关产品(104)

  • GC12943 structure
    GC12943STING agonist-1
    CAS: 702662-50-8
    纯度: >99.50%

    An indirect activator of STING signaling

  • GC13643 structure
    GC13643c-di-AMP
    CAS: 54447-84-6
    纯度: >98.50% / >95.00%

    C-di-AMP是STING(刺激内质网的蛋白)的激动剂,通过与该跨膜蛋白结合,激活TBK3-IRF3信号通路,进而引发I型IFN和TNF的产生。

  • GC13693 structure
    GC13693Omaveloxolone (RTA-408)
    CAS: 1474034-05-3
    纯度: >99.00% / >98.00%

    Omaveloxolone (RTA-408)是一种抗氧化炎症调节剂（AIM），可激活Nrf2并抑制一氧化氮（NO）的生成。

  • GC14727 structure
    GC14727CCCP
    CAS: 555-60-2
    纯度: >98.00% / >99.50%

    Carbonylcyanide-3-chlorophenylhydrazone (CCCP) 是一种质子载体，可导致线粒体内膜中的质子梯度解偶联，从而抑制 ATP 合成速率。

  • GC15048 structure
    GC15048Cyclic di-GMP
    CAS: 61093-23-0
    纯度: >98.00% / >99.50%

    Cyclic di-GMP是一种干扰素基因刺激因子（STING）激动剂。Cyclic di-GMP是一种环状二核苷酸，是细菌第二信使，能够调节不同细菌的生物膜形成、运动性和毒力。

  • GC16280 structure
    GC16280DMXAA (Vadimezan)
    CAS: 117570-53-3
    纯度: >98.00% / >97.00%

    DMXAA (Vadimezan)是一种选择性的DT-心肌黄酶抑制剂，Ki值为20μM，IC50值为62.5μM。

  • GC18782 structure
    GC18782CAY10657
    CAS: 494772-86-0

    A likely inhibitor of IKK2 kinase

  • GC18988 structure
    GC18988ML RR-S2 CDA (ammonium salt)
    CAS: 1638750-96-5
    纯度: >98.00%

    An activator of STING

  • GC19526 structure
    GC19526Cyclic di-GMP disodium
    CAS: 2222132-40-1
    纯度: >99.00% / >99.50% / >98.50%

    Cyclic di-GMP disodium是一种由细菌合成的环二核苷酸信号分子，是STING激动剂。

  • GC25014 structure
    GC250143',3'-cGAMP
    CAS: 849214-04-6(freeacid)

    3',3'-cGAMP (3',3'-cyclic GMP-AMP, Cyclic GMP-AMP, cGAMP) activates the endoplasmic reticulum (ER)-resident receptor stimulator of interferon genes (STING), thereby inducing an antiviral state and the secretion of type I IFNs.

  • GC31649 structure
    GC31649ADU-S100 (ML RR-S2 CDA)
    CAS: 1638241-89-0
    纯度: >99.00%

    ADU-S100 (ML RR-S2 CDA) (MIW815) 是干扰素基因刺激物 (STING) 的激活剂，可导致有效的全身性肿瘤消退和免疫。

  • GC31696 structure
    GC31696cGAMP (Cyclic AMP-GMP)
    CAS: 849214-04-6

    cGAMP (Cyclic AMP-GMP)是一种环状二核苷酸，是哺乳动物细胞内的第二信使，是在细胞受到威胁时“即时”合成的。

  • GC31875 structure
    GC31875CL656 (c-[2'FdAMP(S)-2'FdIMP(S)])
    CAS: 1951464-79-1

    CL656 (c-[2'FdAMP(S)-2'FdIMP(S)]) 是干扰素基因 (STING) 刺激物的激活剂。

  • GC33823 structure
    GC33823C-176 (STING inhibitor 1)
    CAS: 314054-00-7
    纯度: >99.00% / >98.00%

    C-176（STING 抑制剂 1）强烈降低 STING 介导的，但不降低 RIG-I 或 TBK1 介导的 IFNβ 报告基因活性。

  • GC34322 structure
    GC34322STING ligand-1
    CAS: 2365039-41-2

    STINGligand-1是一种STING配体，作用于HAQSTING的IC50为68nM。

  • GC34329 structure
    GC34329ChX710
    CAS: 2438721-44-7
    纯度: >99.00% / >98.50%

    ChX710是一种小分子化合物，能够启动I型干扰素对胞质DNA的反应。

  • GC34610 structure
    GC34610H-151
    CAS: 941987-60-6
    纯度: >99.50% / >98.00%

    H-151是STING的低分子量拮抗剂,可阻断激活诱导的STING棕榈酰化,对STING信号传导有显著抑制作用,可用于自身炎症性疾病的研究。

  • GC35853 structure
    GC35853diABZI STING agonist-1
    CAS: 2138299-33-7
    纯度: >99.00% / >98.00%

    diABZI STING agonist-1是干扰素基因刺激物（STING）途径的激动剂，其在人和小鼠中的EC50值分别为130nM 和186nM。

  • GC35854 structure
    GC35854diABZI STING agonist-1 Tautomerism
    CAS: 2138498-18-5
    纯度: >98.00%

    diABZI STING agonist (diABZI STING agonist-1, Compound 3, Tautomerism) is a potent non-nucleotide STING agonist and has tremendous potential to improve treatment of cancer in humans.

  • GC35855 structure
    GC35855diABZI STING agonist-1 trihydrochloride
    CAS: 2138299-34-8
    纯度: >98.50% / >98.00%

    diABZI STING agonist-1 trihydrochloride 作为一种 STING 激动剂，通过未知受体内化到细胞质中并诱导 STING 的激活和二聚化，然后是 TBK1/IRF3 磷酸化，从而导致 I 型 IFN 反应。

  • GC37692 structure
    GC37692STING agonist-3
    CAS: 2138299-29-1
    纯度: >99.50%

    A STING agonist

  • GC37693 structure
    GC37693STING agonist-4
    CAS: 2138300-40-8
    纯度: >98.00%

    A STING agonist

  • GC38494 structure
    GC38494C-178
    CAS: 329198-87-0
    纯度: >99.50%

    A STING inhibitor

  • GC39161 structure
    GC39161ADU-S100 disodium salt
    CAS: 1638750-95-4
    纯度: >99.00% / >98.00%

    ADU-S100 disodium salt（MIW815 disodium salt）是干扰素基因刺激蛋白（STING）的激活剂，Kd为4.61±0.42μM。