diABZI STING agonist-3 is an agonist of stimulator of interferon genes (STING).1 It binds to STING (IC50 = 0.32 nM in a FRET assay) and induces STING transcriptional activity in a reporter assay (EC50 = 31.62 nM). diABZI STING agonist-3 increases protein levels of Nod-like receptor protein 3 (NLRP3), IL-1β, and IL-18, but not cGAS or mtDNA, in macrophages.2
1.Charnley, A.K., Darcy, M.G., Dodson, J.W., et al.Heterocyclic amides useful as protein modulators(2017) 2.Ning, L., Wei, W., Wenyang, J., et al.Cytosolic DNA-STING-NLRP3 axis is involved in murine acute lung injury induced by lipopolysaccharideClin. Transl. Med.10(7)e228(2020)