diABZI STING agonist-2 is an agonist of stimulator of interferon genes (STING).1 It binds to STING with an apparent Kd value of 1.6 nM. It is selective for STING over the acute phase reactant orosomucoid 1 (ORM1; apparent Kd = 79 nM). diABZI STING agonist-2 increases phosphorylation of interferon regulatory factor 3 (IRF3) and STING in human peripheral blood mononuclear cells (PBMCs). It also induces secretion of IFN-β from PBMCs (EC50 = 3.1 ?M).
1.Ramanjulu, J.M., Pesiridis, G.S., Yang, J., et al.Design of amidobenzimidazole STING receptor agonists with systemic activityNature564(7736)439-443(2018)