Ras

GGTI298 Trifluoroacetate是一种选择性、不可逆的香叶基香叶酰转移酶I（GGTase-I）抑制剂（IC 50 = 3μM)。

(rac)-Antineoplaston A10 是 Antineoplaston A10 的外消旋体。 Antineoplaston A10 是一种潜在的 Ras 抑制剂，可用于治疗神经胶质瘤、淋巴瘤、星形细胞瘤和乳腺癌。

Pan-RAS-IN-1, a pan-Ras inhibitor, binds to KRasG12D-GppNHp with a Kd less than 20 μM in MST, ITC and NMR assays, also binds to Ras proteins and exhibits lethality in cells partially dependent on expression of Ras proteins.

Rhosin hydrochloride是一种有效的、特异性的RhoA亚家族Rho GTPases小分子抑制剂，能够特异性地结合RhoA并抑制RhoA与鸟嘌呤核苷酸交换因子（GEF）的相互作用，其解离常数（Kd）约为0.4μM。

1A-116 is a Rac1 inhibitor, with antitumoral and antimetastatic effects in several types of cancer, such as breast cancer, prevents Rac1-regulated processes involved in the primary tumorigenesis and metastastic processes.

MBQ-167是Ras相关的C3型肉毒素底物(Rac)和细胞分裂周期蛋白(Cdc42)的双抑制剂，其对Rac1/2/3的IC50值为103nM，对Cdc42的IC50值为78nM。

K-Ras-IN-1 (MDK-3017) inhibits K-Ras by binding to K-Ras in a hydrophobic pocket that is occupied by Tyr-71 in the apo-Ras crystal structure.

An inhibitor of the Rho-GEF protein-protein interaction

An inhibitor of the K-Ras-SOS1 protein-protein interaction

BDP9066是一种选择性的肌强直性营养不良激酶相关的Cdc42结合激酶（MRCK）抑制剂，在SCC12细胞中对MRCKβ的IC 50 为64nM，对MRCKα/β的Ki值分别为0.0136nM和0.0233nM。

ARS-1620是一种高选择性的、具有口服活性的KRAS p.G12C突变蛋白抑制剂。

Y16 is an inhibitor of G-protein-coupled Rho GEFs. It blocks the binding of LARG, a DBL-family Rho guanine nucleotide exchange factor, with Rho (Kd = 80 nM).

ARS-1630是突变型K-RasG12C的新型抑制剂，来自专利WO2015054572A1。

ARS-1323是突变型K-RasG12C的新型抑制剂，来自专利WO2015054572A1。

KRASG12Cinhibitor5是一种KRasG12C抑制剂，详细信息请参考专利文献WO2017201161A1中的化合物147。

KRasG12Cinhibitor2是KRasG12C的抑制剂，来自专利US20180072723A1。

KRasG12Cinhibitor1是KRasG12C的抑制剂，来自专利US20180072723A1。

KRasG12Cinhibitor3是KRasG12C的抑制剂，来自专利US20180072723A1。

KRasG12Cinhibitor1是KRasG12C的抑制剂，来自专利US20180072723A1。

6H05 is a selective, and allosteric inhibitor of oncogenic K-Ras(G12C).

Antineoplaston A10 is a naturally occurring substance in the human body that that can be potentially used for the treatment of glioma, lymphoma, astrocytoma and breast cancer. The main ingredient active of antineoplaston A10 (Phenylacetylglutamine, PG) inhibits RAS and promotes apoptosis.

BI-2852 is a potent inhibitor of KRAS that binds with nanomolar affinity to a pocket between switch I and II on RAS. BI-2852 blocks all GEF, GAP, and effector interactions with KRAS, leading to inhibition of downstream signaling and an antiproliferative effect in the low micromolar range in KRAS mutant cells.

Diazepinomicin (TLN-4601) 是Micromonospora sp 的次生代谢产物，可抑制EGF 诱导的 Ras-ERK MAPK 信号通路，可诱导凋亡。是一种可用于 K-Ras 突变型的抗肿瘤药物。

GGTI298是一种选择性、不可逆的香叶基香叶酰转移酶I（GGTase-I）抑制剂（IC 50 = 3μM)。