Ras(Ras蛋白)

Cat.No. 产品名称 Information

GC34188 KRas G12C inhibitor 2 KRasG12Cinhibitor2是KRasG12C的抑制剂，来自专利US20180072723A1。

GC34162 KRAS G12C inhibitor 5 KRASG12Cinhibitor5是一种KRasG12C抑制剂，详细信息请参考专利文献WO2017201161A1中的化合物147。

GC34114 ARS-1323 ARS-1323是突变型K-RasG12C的新型抑制剂，来自专利WO2015054572A1。

GC34091 ARS-1630 ARS-1630是突变型K-RasG12C的新型抑制剂，来自专利WO2015054572A1。

GC34088 Y16 Y16 is an inhibitor of G-protein-coupled Rho GEFs. It blocks the binding of LARG, a DBL-family Rho guanine nucleotide exchange factor, with Rho (Kd = 80 nM).

GC34055 ARS-1620 ARS-1620是一种高选择性的、具有口服活性的KRAS p.G12C突变蛋白抑制剂。

GC33340 BDP9066 BDP9066是一种选择性的肌强直性营养不良激酶相关的Cdc42结合激酶（MRCK）抑制剂，在SCC12细胞中对MRCKβ的IC₅₀为64nM，对MRCKα/β的Ki值分别为0.0136nM和0.0233nM。

GC33186 BAY-293

(R)-6,7-二甲氧基-2-甲基-N-(1-(4-(2-((甲基氨基)甲基)苯基)噻吩-2-基)乙基)喹唑啉-4-胺

An inhibitor of the K-Ras-SOS1 protein-protein interaction

GC33167 Rhosin An inhibitor of the Rho-GEF protein-protein interaction

GC33153 K-Ras-IN-1 K-Ras-IN-1 (MDK-3017) inhibits K-Ras by binding to K-Ras in a hydrophobic pocket that is occupied by Tyr-71 in the apo-Ras crystal structure.

GC32970 MBQ-167

MBQ-167是Ras相关的C3型肉毒素底物(Rac)和细胞分裂周期蛋白(Cdc42)的双抑制剂，其对Rac1/2/3的IC50值为103nM，对Cdc42的IC50值为78nM。

GC32770 1A-116 1A-116 is a Rac1 inhibitor, with antitumoral and antimetastatic effects in several types of cancer, such as breast cancer, prevents Rac1-regulated processes involved in the primary tumorigenesis and metastastic processes.

GC32729 Rhosin hydrochloride

G04

Rhosin hydrochloride是一种有效的、特异性的RhoA亚家族Rho GTPases小分子抑制剂，能够特异性地结合RhoA并抑制RhoA与鸟嘌呤核苷酸交换因子（GEF）的相互作用，其解离常数（Kd）约为0.4μM。

GC32716 Pan-RAS-IN-1 Pan-RAS-IN-1, a pan-Ras inhibitor, binds to KRasG12D-GppNHp with a Kd less than 20 μM in MST, ITC and NMR assays, also binds to Ras proteins and exhibits lethality in cells partially dependent on expression of Ras proteins.