6H05 is a selective, and allosteric inhibitor of oncogenic K-Ras(G12C).
6H05 gives the greatest degree of modification, which allosterically modifies the oncogenic G12C mutant of highly homologous protein H-Ras without affecting wild-type K-Ras. [1]. Furthermore, 6H05 can be used as an intermediate for the synthesis of other oncogenic K-Ras(G12C) inhibitors. [2]
[1] Ostrem JM, et al. Nature. 2013, 503(7477), 548-551. [2] Lu S, et al. Med Res Rev. 2014, 34(6), 1242-1285.