GlpBio

nAChR

nAChR(烟碱型乙酰胆碱受体)

nAChRs (nicotinic acetylcholine receptors) are neuron receptor proteins that signal for muscular contraction upon a chemical stimulus. They are cholinergic receptors that form ligand-gated ion channels in the plasma membranes of certain neurons and on the presynaptic and postsynaptic sides of theneuromuscular junction. Nicotinic acetylcholine receptors are the best-studied of the ionotropic receptors. Like the other type of acetylcholine receptor-the muscarinic acetylcholine receptor (mAChR)-the nAChR is triggered by the binding of the neurotransmitter acetylcholine (ACh). Just as muscarinic receptors are named such because they are also activated by muscarine, nicotinic receptors can be opened not only by acetylcholine but also by nicotine —hence the name "nicotinic".

nAChR 相关产品(99)

  • GC15178 structure
    GC15178Hexamethonium Bromide
    CAS: 55-97-0
    纯度: >98.00%

    A nondepolarizing neuromuscular blocking agent

  • GC15667 structure
    GC15667Atracurium Besylate
    CAS: 64228-81-5
    纯度: >98.50%

    A neuromuscular blocking drug

  • GC15941 structure
    GC15941EVP-6124
    CAS: 550999-75-2

    A partial agonist of α7 subunit-containing nAChRs

  • GC16143 structure
    GC16143Varenicline Hydrochloride
    CAS: 230615-23-3
    纯度: >98.50%

    Varenicline Hydrochloride (CP 526555 hydrochloride) 是一种高亲和力、选择性的 α4β2 尼古丁乙酰胆碱受体 (nAChR) 部分激动剂和完整的 α7 nAChR 激动剂。

  • GC16255 structure
    GC16255Decamethonium Bromide
    CAS: 541-22-0
    纯度: >98.00%

    A depolarizing neuromuscular blocking agent

  • GC16911 structure
    GC16911CGS 9343B
    CAS: 109826-27-9
    纯度: >98.00%

    A calmodulin inhibitor

  • GC16937 structure
    GC16937Carbamoylcholine chloride
    CAS: 51-83-2
    纯度: >98.00% / >99.00%

    Cholinergic receptor agonist

  • GC18631 structure
    GC186314BP-TQS
    CAS: 360791-49-7

    An agonist of α7 subunit-containing nAChRs

  • GC19351 structure
    GC19351Tebanicline hydrochloride
    CAS: 203564-54-9

    A potent agonist of neuronal α4β2 subunit-containing nAChRs

  • GC30807 structure
    GC30807ZSET1446 (ST-101)
    CAS: 887603-94-3
    纯度: >98.00%

    ZSET1446 (ST-101) 是一种新型认知增强剂，可显着改善各种类型的阿尔茨海默病 (AD) 模型中的学习缺陷。

  • GC30866 structure
    GC30866Anabasine ((S)-Anabasine)
    CAS: 494-52-0
    纯度: >99.00%

    Anabasine ((S)-Anabasine) ((S)-Anabasine ((S)-Anabasine)) 是一种生物碱，在烟草 (Nicotiana) 中是一种微量成分。

  • GC31084 structure
    GC31084(-)-(S)-B-973B
    CAS: 2244989-34-0
    纯度: >99.50%

    (-)-(S)-B-973B为一种有效的α7nAChR别构激动剂和正别构调节剂，具有镇痛作用。

  • GC31209 structure
    GC31209Cyclodrine hydrochloride
    CAS: 78853-39-1

    Cyclodrinehydrochloride是一种胆碱能(毒蕈碱，烟碱)受体(mAChR和nAChR)拮抗剂。

  • GC31313 structure
    GC31313S16961 (S169611)
    CAS: 153874-14-7

    S16961 (S169611) 是一种烟碱受体激动剂。

  • GC32185 structure
    GC32185Dinotefuran (MTI-446)
    CAS: 165252-70-0
    纯度: >98.50%

    A neonicotinoid insecticide

  • GC33741 structure
    GC33741Nelonicline (ABT-126)
    CAS: 1026134-63-3
    纯度: >99.00%

    Nelonicline (ABT-126) (ABT-126) 是一种具有口服活性和选择性的 α7 烟碱样受体激动剂，对 α7 人脑中的 nAChRs (Ki=12.3 nM) 具有高亲和力。

  • GC34079 structure
    GC34079Monepantel (AAD1566)
    CAS: 887148-69-8
    纯度: >99.50%

    Monepantel (AAD1566)是一种氨基乙腈衍生物类驱虫药，Monepantel可抑制mTOR/p70S6K信号通路诱导自噬。

  • GC34959 structure
    GC34959(+)-Sparteine
    CAS: 492-08-0
    纯度: >98.60%

    A quinolizidine alkaloid

  • GC35538 structure
    GC35538BNC375
    CAS: 1557240-80-8
    纯度: >99.50%

    BNC375 是一种口服有效的选择性 α7nAChRs I 型正向变构调节剂，EC50 为 1.9 μM。

  • GC35858 structure
    GC35858Dianicline
    CAS: 292634-27-6

    Dianicline是一种α4β2烟碱型乙酰胆碱受体部分激动剂，一类包括伐尼克兰和金雀花碱的戒烟药物。

  • GC36942 structure
    GC36942PNU-282987 S enantiomer free base
    CAS: 737727-12-7
    纯度: >99.50%

    PNU-282987 S enantiomer free base is the S-enantiomer of PNU-282987 free base, which is an α7 nicotinic acetylcholine receptor (α7 nAChR) agonist.

  • GC36952 structure
    GC36952Pozanicline
    CAS: 161417-03-4

    Pozanicline (ABT-089) 是一种新型的胆碱能药物，是 α4β2* nAChRs 部分激动剂，显示对 α6β2* 和 α4α5β2 nAChR 亚型的高选择性。Pozanicline 与 [3H] cytisine位点的结合亲和力 (Ki; rat) 为 16.7 nM。Pozanicline 逆转尼古丁戒断诱导的认知缺陷，可能是尼古丁成瘾的新治疗策略的有效组成部分。

  • GC37543 structure
    GC37543Rivanicline
    CAS: 15585-43-0

    Rivanicline (RJR-2403) 是神经元烟碱受体，对α4β2亚型有高度选择性，Ki为26 nM，比对α7受体的抑制性高超过1000倍。

  • GC37544 structure
    GC37544Rivanicline hemioxalate

    Rivanicline hemioxalate (RJR-2403 hemioxalate) 是神经元烟碱受体激动剂，对α4β2亚型有高度选择性，Ki为26 nM，而对α7受体的Ki则为36000 nM。