GlpBio

Anabasine ((S)-Anabasine)

目录号: GC30866纯度: >99.00%同义词: (+)-假木贼碱; (S)-Anabasine; (+)-Anabasine
Anabasine ((S)-Anabasine) ((S)-Anabasine ((S)-Anabasine)) 是一种生物碱，在烟草 (Nicotiana) 中是一种微量成分。
Anabasine ((S)-Anabasine)
Cas No.: 494-52-0
规格价格库存数量操作
10mg¥536.00现货
1
25mg¥803.00现货
1
50mg¥1,428.00现货
1
100mg¥2,499.00现货
1
10mM (in 1mL DMSO)¥589.00现货
1
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文献被引

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产品描述 Description

Anabasine is a nicotinic receptor agonist.

Anabasine significantly reverses the impairment at the 0.2 mg/kg (p<0.05) and 2 mg/kg doses (p<0.025). Anabasine does not have any significant effects on response latency when administered alone. The 0.06 mg/kg Anabasine dose, in fact, significantly (p<0.05) exacerbates the dizocilpine-induced impairment. None of these Anabasine doses affects choice accuracy on their own. Individual dose comparisons show that the 0.06 mg/kg Anabasine dose plus dizocilpine (6.7±2.6) causes a significant (p<0.05) increase in non-response trials compare with dizocilpine alone (2.1±0.8)[1].

[1]. Levin ED, et al. Effects of tobacco smoke constituents, anabasine and anatabine, on memory and attention in female rats. J Psychopharmacol. 2014 Oct;28(10):915-22.

实验参考方法 Experimental Reference Method

Animal experiment:

Adult (age range 4 to 16 months) female Sprague-Dawley rats are used in this study. One group of rats (N=12) is trained on the radial arm maze test of working and reference memory and undergo tests of an acute dose-response of Anabasine (0.02, 0.2, 1 and 2 mg/kg). Then, two doses of Anabasine (0.2 and 2 mg/kg) are tested alone or in combination with the glutamate NMDA antagonist dizocilpine (0.05 mg/kg). The saline vehicle is used as vehicle control and dizocilpine alone is used as an impaired control. All conditions are given to each rat in a repeated measures counterbalanced design[1].

References:

[1]. Levin ED, et al. Effects of tobacco smoke constituents, anabasine and anatabine, on memory and attention in female rats. J Psychopharmacol. 2014 Oct;28(10):915-22.

产品文档 Product Documents

Purity:>99.00%Appearance:A liquid

化学性质Chemical Properties

CAS 号
494-52-0
同义词
(+)-假木贼碱; (S)-Anabasine; (+)-Anabasine
SMILES
C1([C@H]2NCCCC2)=CC=CN=C1
分子式
C10H14N2
分子量
162.23 g/mol
溶解性
DMSO : 100 mg/mL (616.41 mM)
保存条件
Store at -20&#176;C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol