p53
The p53 tumor suppressor is a 53 kDa nuclear phosphoprotein of 393 amino acids that is encoded by the TP53 gene (20 kb with 11 exons and 10 introns) and characterized by the presence of several structural and functional domains, including a N-terminus, a central core domain, a C-terminal region, a strongly basic carboxyl-terminal regulatory domain, a nuclear localization signal sequence and three nuclear export signal sequence. The p53 is considered as a major “guardian of genome” for its activities in a wide range of cellular events, including cell-cycle regulation, induction of apoptosis, gene amplification, DNA recombination, chromosomal segregation and cellular senescence.
p53 相关产品(122)
- GN10203Ziyuglycoside ICAS: 35286-58-9纯度: >99.00%
A triterpenoid saponin with diverse biological activities
- GC11247PRIMA-1METCAS: 5291-32-7纯度: >99.00% / >98.00%
PRIMA-1MET是一种能够恢复肿瘤抑制功能的小分子有机化合物，主要靶向突变型p53，诱导多种癌细胞死亡。
- GC12793RITA (NSC 652287)CAS: 213261-59-7纯度: >99.00%
RITA (NSC 652287)是一种三环噻吩衍生物，可结合p53dN（K d =1.5nM）并阻断p53-HDM-2相互作用，抑制p53泛素化。
- GP10028tumor protein p53 binding protein fragment [Homo sapiens]/[Mus musculus]
P53 binding protein fragment
- GC10282PiperlongumineCAS: 20069-09-4纯度: >99.00% / >98.00%
Piperlongumine是从 Piper longum L. 中提取的天然生物碱化合物，具有多种药理活性，包括抗肿瘤、脂质代谢调节、抗血小板聚集和镇痛活性等。
- GC12658PhiKan 083CAS: 880813-36-5纯度: >98.00%
PhiKan 083 是一种咔唑衍生物，可与表面腔结合并稳定 Y220C（一种 p53 突变体），Kd 为 167 μM。 PhiKan 083 可用于癌症研究。
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC74358 | PNC-27 acetate | - | >99.00% | |
PNC-27 acetate是一种嵌合p53-穿透素肽，以p53肽样结构与HDM-2结合，诱导选择性膜孔形成并导致癌细胞裂解。 | ||||
| GC91297 | Cholesterol-Doxorubicin | - | >95.00% | |
一种阿霉素的前药形式。 | ||||
| GN10203 | Ziyuglycoside I | 35286-58-9 | >99.00% | |
A triterpenoid saponin with diverse biological activities | ||||
| GC11247 | PRIMA-1MET | 5291-32-7 | >99.00% / >98.00% | |
PRIMA-1MET是一种能够恢复肿瘤抑制功能的小分子有机化合物，主要靶向突变型p53，诱导多种癌细胞死亡。 | ||||
| GC12086 | PRIMA-1 | 5608-24-2 | >98.00% | |
A re-activator of the apoptotic function of mutant p53 proteins | ||||
| GC12117 | JNJ-26854165 (Serdemetan) | 881202-45-5 | >99.00% | |
An antagonist of MDM2 action | ||||
| GC14165 | Tenovin-1 | 380315-80-0 | >99.50% | |
A small molecule activator of p53 | ||||
| GC10896 | Cyclic Pifithrin-α hydrobromide | 511296-88-1 | >98.00% | |
A stable inhibitor of p53 | ||||
| GC11065 | Pifithrin-μ | 64984-31-2 | >98.00% | |
Pifithrin-μ是p53和HSP70的抑制剂。 | ||||
| GC12793 | RITA (NSC 652287) | 213261-59-7 | >99.00% | |
RITA (NSC 652287)是一种三环噻吩衍生物，可结合p53dN（K d =1.5nM）并阻断p53-HDM-2相互作用，抑制p53泛素化。 | ||||
| GC13019 | RG7112 | 939981-39-2 | >99.50% | |
An inhibitor of the MDM2-p53 interaction | ||||
| GP10028 | tumor protein p53 binding protein fragment [Homo sapiens]/[Mus musculus] | - | - | |
P53 binding protein fragment | ||||
| GP10036 | p53 tumor suppressor fragment | - | - | |
Regulates cell cycle | ||||
| GC11594 | RG7388 | 1229705-06-9 | >99.50% | |
RG7388是一种具有口服活性的MDM2（IC 50 =6nM）拮抗剂，RG7388通过抑制MDM2-p53相互作用来激活p53通路。 | ||||
| GC10315 | Plumbagin | 481-42-5 | >99.50% / >98.50% | |
A natural naphthoquinone | ||||
| GC15840 | CP 31398 dihydrochloride | 1217195-61-3 | >99.00% | |
A p53 stabilizing agent | ||||
| GC10282 | Piperlongumine | 20069-09-4 | >99.00% / >98.00% | |
Piperlongumine是从 Piper longum L. 中提取的天然生物碱化合物，具有多种药理活性，包括抗肿瘤、脂质代谢调节、抗血小板聚集和镇痛活性等。 | ||||
| GC10650 | HLI 373 | 502137-98-6 | - | |
HLI 373 是一种有效的 Hdm2 抑制剂。 | ||||
| GC15404 | NSC 319726 | 71555-25-4 | >98.00% | |
A p53 reactivator | ||||
| GC15828 | AMG232 | 1352066-68-2 | >98.00% | |
An inhibitor of the MDM2 and p53 interaction | ||||
| GC12893 | MIRA-1 | 72835-26-8 | >98.00% | |
MIRA-1是一种马来酰亚胺类化合物，能够恢复突变型p53的野生型构象及功能。 | ||||
| GC15621 | NSC 146109 hydrochloride | 59474-01-0 | >98.00% | |
An activator of p53 | ||||
| GC12658 | PhiKan 083 | 880813-36-5 | >98.00% | |
PhiKan 083 是一种咔唑衍生物，可与表面腔结合并稳定 Y220C（一种 p53 突变体），Kd 为 167 μM。 PhiKan 083 可用于癌症研究。 | ||||
| GC10589 | RETRA hydrochloride | 1036069-26-7 | - | |
Antitumor agent | ||||