p53
The p53 tumor suppressor is a 53 kDa nuclear phosphoprotein of 393 amino acids that is encoded by the TP53 gene (20 kb with 11 exons and 10 introns) and characterized by the presence of several structural and functional domains, including a N-terminus, a central core domain, a C-terminal region, a strongly basic carboxyl-terminal regulatory domain, a nuclear localization signal sequence and three nuclear export signal sequence. The p53 is considered as a major “guardian of genome” for its activities in a wide range of cellular events, including cell-cycle regulation, induction of apoptosis, gene amplification, DNA recombination, chromosomal segregation and cellular senescence.
p53 相关产品(122)
- GC407109(Z),11(E),13(E)-Octadecatrienoic Acid methyl esterCAS: 4175-47-7纯度: >98.00%
A polyunsaturated fatty acid methyl ester
- GC407859(Z),11(E),13(E)-Octadecatrienoic Acid ethyl esterCAS: 42021-86-3纯度: >98.00%
A polyunsaturated fatty acid ethyl ester
- GC42785Amifostine (hydrate)CAS: 112901-68-5纯度: >98.00%
Amifostine (hydrate)是一种广谱的正常细胞保护剂，主要用于减轻化疗或放疗对正常组织的毒性。
- GC43297Coenzyme Q2CAS: 606-06-4纯度: >95.00%
A biosynthetic precursor to CoQ 10 and an inhibitor of mitochondrial complex I
- GC47853Paclitaxel-d5CAS: 1129540-33-5纯度: >99.00%
An internal standard for the quantification of paclitaxel
- GC61352Triglycidyl isocyanurateCAS: 2451-62-9纯度: >98.00%
Triglycidyl Isocyanurate (Teroxirone, Tris(2,3-epoxypropyl) Isocyanurate, TGI, TGIC) is a triazene triepoxide with antineoplastic activity. It inhibits growth of human non-small cell lung cancer cells by activating p53. Triglycidyl Isocyanurate alkylates and cross-links DNA, thereby inhibiting DNA replication. Triglycidyl Isocyanurate is also used in various polyester powder coatings in the metal finishing industry.
- GC61608HLI373 dihydrochlorideCAS: 1782531-99-0
HLI373dihydrochloride是一种有效的Hdm2抑制剂。HLI373抑制Hdm2泛素连接酶活性。HLI373dihydrochloride可有效诱导肿瘤细胞(对DNA破坏剂敏感的)凋亡(apoptosis)。具有抗疟疾(antimalarial)活性。
- GC61804Amifostine thiolCAS: 31098-42-7纯度: >98.00%
Amifostinethiol(WR-1065)是细胞保护剂Amifostine的活性代谢物。Amifostinethiol是一种具有辐射防护能力的细胞保护剂。Amifostinethiol通过JNK依赖的信号通路激活p53。
- GC62598MI-1061 TFACAS: 1410737-35-7
MI-1061 TFA 是一种有效的，口服可生物利用的，化学稳定性的 MDM2 (MDM2-p53 互作) 抑制剂 (IC50=4.4 nM; Ki=0.16 nM)。MI-1061 TFA 激活小鼠 SJSA-1 异种移植瘤组织中 p53 并诱导凋亡，具有抗肿瘤活性。
- GC62621Milademetan tosylate hydrateCAS: 2095625-97-9纯度: >98.00%
Milademetan (DS-3032) tosylate hydrate 是特异性的、具有口服活性的 MDM2 抑制剂，用于急性髓系白血病和实体肿瘤的研究。Milademetan (DS-3032) tosylate hydrate 可诱导 G1 细胞周期阻滞、衰老和凋亡。
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC37761 | Tenovin-6 Hydrochloride | 1011301-29-3 | >98.00% | |
A small molecule activator of p53 | ||||
| GC38812 | MD-224 | 2136247-12-4 | >98.00% / >99.00% | |
MD-224 是一种作用强大的MDM2蛋白降解剂，由Cereblon和MDM2配体组成，能够促使MDM2蛋白迅速降解。 | ||||
| GC40710 | 9(Z),11(E),13(E)-Octadecatrienoic Acid methyl ester | 4175-47-7 | >98.00% | |
A polyunsaturated fatty acid methyl ester | ||||
| GC40785 | 9(Z),11(E),13(E)-Octadecatrienoic Acid ethyl ester | 42021-86-3 | >98.00% | |
A polyunsaturated fatty acid ethyl ester | ||||
| GC41643 | 9(Z),11(E),13(E)-Octadecatrienoic Acid | 506-23-0 | >95.00% | |
A polyunsaturated fatty acid | ||||
| GC42586 | 6α-hydroxy Paclitaxel | 153212-75-0 | >95.00% | |
A metabolite of paclitaxel | ||||
| GC42785 | Amifostine (hydrate) | 112901-68-5 | >98.00% | |
Amifostine (hydrate)是一种广谱的正常细胞保护剂，主要用于减轻化疗或放疗对正常组织的毒性。 | ||||
| GC43189 | CAY10681 | 1542066-69-2 | >98.00% | |
A dual modulator of p53-MDM2 interaction and NF-κB signaling | ||||
| GC43190 | CAY10682 | 1542066-74-9 | >98.00% | |
A dual inhibitor of p53-Mdm2 interaction and NF-κB signaling | ||||
| GC43239 | Chk2 Inhibitor | 724708-21-8 | >95.00% | |
A Chk2 inhibitor | ||||
| GC43297 | Coenzyme Q2 | 606-06-4 | >95.00% | |
A biosynthetic precursor to CoQ 10 and an inhibitor of mitochondrial complex I | ||||
| GC43408 | Deoxycholic Acid (sodium salt hydrate) | 145224-92-6 | >95.00% | |
A secondary bile acid | ||||
| GC43565 | Doxorubicinol (hydrochloride) | 63950-05-0 | >90.00% | |
A doxorubicin metabolite | ||||
| GC44652 | PK7242 (maleate) | - | >95.00% | |
An inducer of reactivation of mutant p53 | ||||
| GC45758 | Paclitaxel octadecanedioate | 2089211-45-8 | >98.00% | |
A prodrug form of paclitaxel | ||||
| GC47853 | Paclitaxel-d5 | 1129540-33-5 | >99.00% | |
An internal standard for the quantification of paclitaxel | ||||
| GC48652 | Olomoucine II | 500735-47-7 | >98.00% | |
A CDK inhibitor | ||||
| GC61352 | Triglycidyl isocyanurate | 2451-62-9 | >98.00% | |
Triglycidyl Isocyanurate (Teroxirone, Tris(2,3-epoxypropyl) Isocyanurate, TGI, TGIC) is a triazene triepoxide with antineoplastic activity. It inhibits growth of human non-small cell lung cancer cells by activating p53. Triglycidyl Isocyanurate alkylates and cross-links DNA, thereby inhibiting DNA replication. Triglycidyl Isocyanurate is also used in various polyester powder coatings in the metal finishing industry. | ||||
| GC61608 | HLI373 dihydrochloride | 1782531-99-0 | - | |
HLI373dihydrochloride是一种有效的Hdm2抑制剂。HLI373抑制Hdm2泛素连接酶活性。HLI373dihydrochloride可有效诱导肿瘤细胞(对DNA破坏剂敏感的)凋亡(apoptosis)。具有抗疟疾(antimalarial)活性。 | ||||
| GC61804 | Amifostine thiol | 31098-42-7 | >98.00% | |
Amifostinethiol(WR-1065)是细胞保护剂Amifostine的活性代谢物。Amifostinethiol是一种具有辐射防护能力的细胞保护剂。Amifostinethiol通过JNK依赖的信号通路激活p53。 | ||||
| GC62322 | MS7972 | 352553-42-5 | >99.50% | |
MS7972 is a small molecule that blocks human p53 and CREB binding protein association. | ||||
| GC62557 | MDM2-IN-1 | 1410737-09-5 | >95.00% | |
MDM2-IN-1 (Compound 30) 是一种合成的 MDM2-p53 相互作用 (MDM2) 抑制剂，包含反式 (D-)构型。 | ||||
| GC62598 | MI-1061 TFA | 1410737-35-7 | - | |
MI-1061 TFA 是一种有效的，口服可生物利用的，化学稳定性的 MDM2 (MDM2-p53 互作) 抑制剂 (IC50=4.4 nM; Ki=0.16 nM)。MI-1061 TFA 激活小鼠 SJSA-1 异种移植瘤组织中 p53 并诱导凋亡，具有抗肿瘤活性。 | ||||
| GC62621 | Milademetan tosylate hydrate | 2095625-97-9 | >98.00% | |
Milademetan (DS-3032) tosylate hydrate 是特异性的、具有口服活性的 MDM2 抑制剂，用于急性髓系白血病和实体肿瘤的研究。Milademetan (DS-3032) tosylate hydrate 可诱导 G1 细胞周期阻滞、衰老和凋亡。 | ||||