GlpBio

p53

The p53 tumor suppressor is a 53 kDa nuclear phosphoprotein of 393 amino acids that is encoded by the TP53 gene (20 kb with 11 exons and 10 introns) and characterized by the presence of several structural and functional domains, including a N-terminus, a central core domain, a C-terminal region, a strongly basic carboxyl-terminal regulatory domain, a nuclear localization signal sequence and three nuclear export signal sequence. The p53 is considered as a major “guardian of genome” for its activities in a wide range of cellular events, including cell-cycle regulation, induction of apoptosis, gene amplification, DNA recombination, chromosomal segregation and cellular senescence.

p53 相关产品(122)

  • GC10538 structure
    GC10538Pifithrin-α (PFTα)
    CAS: 63208-82-2
    纯度: >98.00%

    Pifithrin-α是一种p53抑制剂。

  • GC16051 structure
    GC16051Nutlin-3
    CAS: 890090-75-2
    纯度: >99.00% / >98.00%

    A racemic mixture of (?)-nutlin-3 and (+)-nutlin-3

  • GC10470 structure
    GC10470Nutlin-3a chiral
    CAS: 675576-98-4
    纯度: >98.00%

    Nutlin-3a 手性是 Nutlin-3 的活性异构体，是鼠类双微体 2 (MDM2) 拮抗剂，IC50 值为 0.09μM。

  • GC11445 structure
    GC11445YH239-EE
    CAS: 1364488-67-4
    纯度: >99.50%

    A prodrug form of YH 239

  • GC11547 structure
    GC11547MI-773 (SAR405838)
    CAS: 1303607-60-4
    纯度: >95.00% / >98.00%

    An inhibitor of MDM2-p53 protein-protein interactions

  • GC11711 structure
    GC11711ONC201
    CAS: 1616632-77-9
    纯度: >99.50% / >98.00%

    ONC201是一种具有口服活性的小分子化合物，属于imipridone类化合物，是多巴胺D2/3受体（DRD2/3）的选择性拮抗剂。

  • GC12337 structure
    GC12337Tenovin-3
    CAS: 1011301-27-1
    纯度: >99.50%

    A small molecule activator of p53

  • GC12508 structure
    GC12508Nutlin-3b
    CAS: 675576-97-3
    纯度: >98.00%

    The less active enantiomer of (–)-nutlin-3

  • GC13590 structure
    GC13590SJ 172550
    CAS: 431979-47-4
    纯度: >98.00%

    A small molecule inhibitor of MDMX

  • GC14634 structure
    GC14634CBL0137
    CAS: 1197996-80-7
    纯度: >98.00%

    CBL0137是一种靶向FACT复合体以调节染色质结构和基因表达的first-in-class小分子化合物，可靶向抑制NF-κB信号通路活性，具有抗癌和抗炎特性。

  • GC14755 structure
    GC14755Inauhzin
    CAS: 309271-94-1
    纯度: >99.00%

    A selective SIRT1 inhibitor

  • GC15225 structure
    GC15225COTI-2
    CAS: 1039455-84-9
    纯度: >98.50%

    An activator of mutant forms of p53

  • GC15258 structure
    GC15258GN25
    CAS: 1227401-27-5

    Inhibits p53-Snail binding

  • GC15394 structure
    GC15394CBL0137 (hydrochloride)
    CAS: 1197397-89-9
    纯度: >98.00%

    CBL0137 (hydrochloride)是一种来自curaxins小分子家族的水溶性且代谢稳定的非遗传毒性抗癌药物，可以激活p53并抑制NF-κB，EC 50 值分别为0.37和0.47μM。

  • GC15613 structure
    GC15613p-nitro-Cyclic Pifithrin-α
    CAS: 60477-38-5
    纯度: >99.00%

    A cell-permeable form of cyclic PFT-α

  • GC15812 structure
    GC15812p-nitro-Pifithrin-α
    CAS: 389850-21-9
    纯度: >95.00%

    A cell-permeable inactivator of p53

  • GC15946 structure
    GC15946ReACp53
    纯度: >99.00%

    ReACp53 可以抑制 p53 淀粉样蛋白的形成并挽救癌细胞系中的 p53 功能。

  • GC16151 structure
    GC16151NSC348884
    CAS: 81624-55-7
    纯度: >98.00%

    A nucleophosmin inhibitor

  • GC16179 structure
    GC16179NSC59984
    CAS: 803647-40-7
    纯度: >99.50%

    A p53 reactivator

  • GC16296 structure
    GC16296MI-773
    CAS: 1303607-07-9
    纯度: >98.00%

    MI-773 是一种有效的 MDM2-p53 蛋白-蛋白相互作用 (PPI) 抑制剂，对 MDM2 具有高结合亲和力 (Kd=8.2 nM)。 MI-773 具有抗肿瘤活性。

  • GC16371 structure
    GC16371Solasodine
    CAS: 126-17-0
    纯度: >98.00%

    An alkaloid with diverse biological activities

  • GC16436 structure
    GC16436Tenovin-6
    CAS: 1011557-82-6
    纯度: >98.50%

    A small molecule activator of p53

  • GC17262 structure
    GC17262Pifithrin-β
    CAS: 60477-34-1
    纯度: >98.00%

    An inactivator of p53

  • GC18136 structure
    GC18136BH3I-1
    CAS: 300817-68-9
    纯度: >98.00%

    An inhibitor of anti-apoptotic Bcl-2 proteins