Other Apoptosis(其他细胞凋亡)

Cat.No. 产品名称 Information

GC15503 NSC 687852 (b-AP15)

b-AP15

An inhibitor of the deubiquitinases USP14 and UCHL5

GC11561 NSC 95397

Cdc25 Inhibitor IV, PTP Inhibitor XXIX

An irreversible inhibitor of Cdc25 isoforms

GC16151 NSC348884

N1,N1,N2,N2-四[(6-甲基-1H-苯并咪唑-2-基)甲基]-1,2-乙二胺

A nucleophosmin inhibitor

GC12332 NU 7026

2-(4-吗啉基)-4H-萘并[1,2-B]吡喃-4-酮,LY293646

Inhibitor of DNA-dependent protein kinase

GC10470 Nutlin-3a chiral

Nutlin-3a;Nutlin 3a

Nutlin-3a 手性是 Nutlin-3 的活性异构体，是鼠类双微体 2 (MDM2) 拮抗剂，IC50 值为 0.09μM。

GC16145 NVP-BGT226

NVP-BGT226 maleate

A dual PI3K and mTOR inhibitor

GC17555 NVP-TNKS656

TNKS656

A TNKS2 inhibitor

GN10776 Obacunone

黄柏酮

Obacunone 是从 Marsh White 葡萄柚的种子中分离出来的，通过诱导细胞凋亡表现出抗肿瘤活性。

GN10144 Oleandrin

欧夹竹桃苷; PBI-05204

A glycoside with diverse biological activities

GC30110 Oleic acid (9-cis-Octadecenoic acid)

油酸; 9-cis-Octadecenoic acid; 9Z-Octadecenoic acid

油酸（9-顺式-十八碳烯酸）是一种单不饱和的Omega-9脂肪酸，存在于植物和动物中。

GN10457 Oleuropein

橄榄苦苷

A polyphenol

GC16409 Oligomycin B

寡霉素 B

A nonselective inhibitor of the mitochondrial F₁F_O ATP synthase

GC13693 Omaveloxolone (RTA-408)

RTA 408

A synthetic triterpenoid that blocks Keap1/Nrf2 signaling

GC34095 ONC212 A GPR132 agonist

GC14860 Oncrasin 1

1-(4-氯苄基)-1H-吲哚-3-甲醛

An anticancer agent

GC13219 ONO-4059

GS-4059 analog

A derivative of ONO-4059

GC17318 Orlistat

奥利司他; Tetrahydrolipstatin; Ro-18-0647

奥利司他是胰脏和胃中脂肪酶的不可逆抑制剂，是治疗肥胖症的药物。

GC11528 Orotic acid

乳清酸; 6-Carboxyuracil; Vitamin B13

乳清酸 (6-Carboxyuracil) 是嘧啶核苷酸和 RNA 生物合成的前体，从线粒体二氢乳清酸脱氢酶 (DHODH) 中释放出来，通过细胞质 UMP 合酶转化为 UMP。

GN10732 Oroxin B

木蝴蝶苷B

Oroxin B (OB) 是从中草药 Oroxylum indicum (L.) Vent 中分离得到的黄酮类化合物。Oroxin B (OB) 具有明显的抑制作用，通过上调 PTEN、下调 PTEN 诱导肝癌细胞早期凋亡而不是晚期凋亡COX-2、VEGF、PI3K 和 p-AKT.Oroxin B (OB) 在恶性淋巴瘤细胞中选择性诱导肿瘤抑制性 ER 应激。

GC31596 Osajin (CID 95168)

CID 95168; NSC 21565

Osajin (CID 95168) 是存在于 Maclura pomifera 果实中的主要生物活性异黄酮，具有抗肿瘤、抗氧化和抗炎活性。

GC14957 OSI-930

噻尔非尼

A dual inhibitor of Kit and VEGFR2

GN10333 Osthole

蛇床子素; Osthol; NSC 31868

A coumarin with diverse biological activities

GC36821 OSU-T315

OSU-T315 (ILK-IN-1) is a small Integrin-linked kinase (ILK) inhibitor with an IC50 of 0.6 μM, inhibiting PI3K/AKT signaling by dephosphorylation of AKT-Ser473 and other ILK targets (GSK-3β and myosin light chain).

GC25691 OTS514 hydrochloride OTS514 is a highly potent TOPK(T-LAK cell-originated protein kinase) inhibitor with an IC50 value of 2.6 nM. OTS514 induces cell cycle arrest and apoptosis.

GC16511 OTS964 A TOPK inhibitor

GC12011 P276-00

P276-00

P276-00 (P276-00) 是一种有效的细胞周期蛋白依赖性激酶 (CDK) 抑制剂，可抑制 CDK9-cyclinT1、CDK4-cyclin D1 和 CDK1-cyclinB，IC50 分别为 20 nM、63 nM 和 79 nM。 P276-00 (P276-00) 对顺铂耐药细胞具有抗肿瘤活性。

GC11993 PAC-1

Procaspase activating compound 1

An in vitro procaspase-3 activator

GC12773 Palomid 529

P529

An inhibitor of mTORC1 and mTORC2 formation

GC12257 Panobinostat (LBH589)

帕比司他; LBH589; NVP-LBH589

A pan-HDAC inhibitor

GC12718 Pantoprazole

泮托拉唑; BY1023; SKF96022

A proton pump inhibitor

GC36847 Pantoprazole sodium

泮托拉唑钠; BY1023 sodium; SKF96022 sodium

A proton pump inhibitor

GC36848 Pantoprazole sodium hydrate

泮托拉唑钠水合物; BY1023 sodium hydrate; SKF96022 sodium hydrate

A proton pump inhibitor

GN10357 Parthenolide

小白菊内酯; (-)-Parthenolide

Parthenolide是一种NF-κB抑制剂，对Eca109、KYSE-510、SiHa和MCF-7细胞48h的IC₅₀值分别约为10.3、13.3、8.42和9.54µM。

GC40483 Patulin

棒曲霉素; Terinin

A mycotoxin

GC33002 PBOX 6 PBOX6是一种pyrrolo-1,5-benzoxazepine(PBOX)化合物，可作为微管解聚剂和促凋亡剂起作用。

GC18008 PCI-34051

N-羟基-1-(4-甲氧基苄基)-1H-吲哚-6-甲酰胺,PCI34051, PCI 34051

A potent, selective HDAC8 inhibitor

GC15142 PD-1/PD-L1 inhibitor 1 (BMS-1)

BMS-1

PD-1/PD-L1 inhibitor 1 是一种 PD-1/PD-L1 相互作用抑制剂，IC50 值介于 6 和 100 nM . PD-1/PD-L1 调节细胞信号通路和表观遗传修饰，从而抑制 T 细胞和 B 细胞的增殖和效应子功能。

GC32853 PD0166285

6-(2,6-二氯苯基)-2-[[4-[2-(二乙基氨基)乙氧基]苯基]氨基]-8-甲基吡啶并[2,3-D]嘧啶-7(8H)-酮

PD0166285 is a potent Wee1 and Chk1 inhibitor with activity at nanomolar concentrations (IC50=24 nM for Wee1 and 72 nM for Myt1). PD0166285 is also a novel G2 checkpoint abrogator. PD0166285 induces apoptosis.

GC10397 PD0325901

N-[(2R)-2,3-二羟基丙氧基]-3,4-二氟-2-[(2-氟-4-碘苯)氨基]苯甲酰胺,PD0325901,PD-0325901,PD 0325901,PD325901,PD 325901,PD-325901

PD0325901是一种具口服活性、选择性和非ATP竞争性的丝裂原活化蛋白激酶激酶（MEK）抑制剂，IC₅₀值为0.33nM。

GC11015 PD168393 An irreversible EGFR kinase inhibitor

GC17943 PD173074

PD 173074,PD-173074

PD173074是一种ATP竞争性FGFR1和VEGFR2抑制剂，IC₅₀值分别为26nM和100-200nM，对FGFR1的选择性高于PDGFR和c-Src。

GC13592 PD173955

6-(2,6-二氯苯基)-8-甲基-2-[[3-(甲硫基)苯基]氨基]吡啶并[2,3-D]嘧啶-7(8H)-酮

A tyrosine kinase inhibitor

GC12989 PD184352 (CI-1040)

2-[(2-氯-4-碘苯基)氨基]-N-(环丙基甲氧基)-3,4-二氟-苯甲酰胺,PD 184352

A potent MEK inhibitor

GC36865 PEAQX tetrasodium hydrate

NVP-AAM077 tetrasodium hydrate

PEAQX (NVP-AAM077) is an effective and orally available human NMDA antagonist, which shows preference in excess of 100-fold for hNMDA 1A/2A (IC50=of 270 nM) over hNMDA 1A/2B receptors (IC50=29,600 nM).