PD 117519 is an adenosine receptor agonist.1 It selectively binds to adenosine A2 receptors (IC50 = 30 ?M) over A1 receptors (IC50 = 810 ?M) in rat brain membranes. PD 117519 increases heart rate and decreases systolic blood pressure in normotensive dogs when administered at doses of 2 or 10 mg/kg.2
1.Steffen, R.P.Method of treating heart failure and medicaments therefor(1987) 2.Enerson, B.E., Lin, A., Lu, B., et al.Acute drug-induced vascular injury in beagle dogs: Pathology and correlating genomic expressionToxicol. Pathol.34(1)27-32(2006)