Coniferyl ferulate is a monolignol conjugate that has been found in A. sinensis and has diverse biological activities, including antibacterial, antioxidant, enzyme inhibitory, and neuroprotective properties.1,2,3,4 It is active against the Gram-positive bacteria B. subtilis and S. aureus.2 Coniferyl ferulate scavenges 2,2-diphenyl-1-picrylhydrazyl radicals (EC50 = 3.6 ?g/ml) and inhibits glutathione S-transferase (GST; IC50 = 0.3 ?M for the human placental enzyme) in cell-free assays.3,4 Coniferyl ferulate (10 and 50 ?g/ml) reduces cytotoxicity induced by amyloid-β (1-40) (Aβ40) in PC12 cells.3
1.Grabber, J.H., Schatz, P.F., Kim, H., et al.Identifying new lignin bioengineering targets: 1. Monolignol-substitute impacts on lignin formation and cell wall fermentabilityBMC Plant Biol.10114(2010) 2.Chou, S.-H., Everngam, M.C., Sturtz, G., et al.Antibacterial activity of components from Lomatium californicumPhytother. Res.20(2)153-156(2006) 3.Ho, C.C., Kumaran, A., and Hwang, L.S.Bio-assay guided isolation and identification of anti-Alzheimer active compounds from the root of Angelica sinensisFood Chem.114(1)246-252(2009) 4.Chen, C., Wu, C., Lu, X., et al.Coniferyl ferulate, a strong inhibitor of glutathione S-transferase isolated from Radix Angelicae sinensis, reverses multidrug resistance and downregulates P-glycoproteinEvid. Based Complement. Alternat. Med.639083(2013)