Tabersonine is an indole alkaloid that has been found in the beans of Voacanga.1 It inhibits amyloid-β (1-42) (Aβ42) fibril formation and disintegrates preformed Aβ42 fibrils in vitro when used at a concentration of 10 μM. Tabersonine is an intermediate in the biosynthesis of vindoline, a precursor in the synthesis of anticancer agents.2
1.Kai, T., Zhang, L., Wang, X., et al.Tabersonine inhibits amyloid fibril formation and cytotoxicity of Aβ(1-42)ACS Chem. Neurosci.6(6)879-888(2015) 2.Qu, Y., Easson, M.L.A.E., Froese, J., et al.Completion of the seven-step pathway from tabersonine to the anticancer drug precursor vindoline and its assembly in yeastProc. Natl. Acad. Sci. USA112(19)6224-6229(2015)